IPX203 vs Immediate-Release Carbidopa-Levodopa for the Treatment of Motor Fluctuations in Parkinson Disease
This randomized clinical trial evaluates the safety and efficacy of extended-release carbidopa-levodopa (IPX203) compared with immediate-release carbidopa-levodopa in patients with Parkinson disease. (Source: JAMA Neurology)
Source: JAMA Neurology - August 14, 2023 Category: Neurology Source Type: research

Increased Medial Temporal Tau Uptake Without Amyloid- β Positivity
This cohort study examines the pathologic and cognitive changes in older individuals with tau deposition in the medial temporal lobe noted on positron emission tomography without evidence of amyloid- β pathology. (Source: JAMA Neurology)
Source: JAMA Neurology - August 14, 2023 Category: Neurology Source Type: research

Alternate Hemibody Hyperkinetic and Hypokinetic Movement Disorders Due to Strategic Lesions in Cerebral Toxoplasmosis
This case report describes a women with a background of HIV presenting with complex involuntary movements with markedly different phenomenology on the right and left side of her body. (Source: JAMA Neurology)
Source: JAMA Neurology - August 14, 2023 Category: Neurology Source Type: research

Tau Pathology Without A β
Alzheimer disease (AD) is characterized by accumulation of amyloid- β (Aβ) plaques and tau neurofibrillary tangles that can be identified at autopsy or during life with fluid or imaging biomarkers. The presence of Aβ accumulation is an early event that precedes cognitive impairment by at least a decade and, based on the National Institute on Aging–Alzheimer’s Association Research Framework, defines whether an individual is on the AD pathway. The pathologic spread of tau aggregations throughout the brain appears to be triggered by Aβ, a sequence supported by the observation that abnormal tau, especially when present...
Source: JAMA Neurology - August 14, 2023 Category: Neurology Source Type: research

Full Court Press
This essay describes a care team and family rallying around a young girl facing what seem to be insurmountable odds. (Source: JAMA Neurology)
Source: JAMA Neurology - August 7, 2023 Category: Neurology Source Type: research

Hypothermia vs Normothermia on Societal Participation and Cognitive Function at 6 Months After OHCA
This study investigates the effects of targeted hypothermia vs targeted normothermia on functional outcome with focus on societal participation and cognitive function in survivors 6 months after out-of-hospital cardiac arrest. (Source: JAMA Neurology)
Source: JAMA Neurology - August 7, 2023 Category: Neurology Source Type: research

Myelin Oligodendrocyte Glycoprotein –IgA in a Subgroup of Patients With Central Nervous System Demyelination
This cross-sectional study examines laboratory and imaging data for patients with demyelinating central nervous system disease to investigate the frequency of MOG-IgA and associated clinical features. (Source: JAMA Neurology)
Source: JAMA Neurology - August 7, 2023 Category: Neurology Source Type: research

JAMA Neurology
Mission Statement: The mission of JAMA Neurology is to publish and disseminate scientific information primarily important for physicians caring for people with neurologic disorders and for those interested in the structure and function of the normal and diseased human nervous system. The specific aims are to (1) publish timely original research, including clinical trials that will directly improve clinical neurologic care and that will inform efforts to improve neurological health and promote health care equity; (2) report translational research that is pertinent to the understanding of neurologic disease; (3) address topi...
Source: JAMA Neurology - August 1, 2023 Category: Neurology Source Type: research

Error in Figure 2
This article was corrected online. (Source: JAMA Neurology)
Source: JAMA Neurology - August 1, 2023 Category: Neurology Source Type: research

Reducing the Risks of Nuclear War —The Role of Health Professionals
In January 2023, the Science and Security Board of the Bulletin of the Atomic Scientists moved the hands of the Doomsday Clock forward to 90 seconds before midnight, reflecting the growing risk of nuclear war. In August 2022, the UN Secretary-General Ant ónio Guterres warned that the world is now in “a time of nuclear danger not seen since the height of the Cold War.” The danger has been underlined by growing tensions between many nuclear armed states. As editors of health and medical journals worldwide, we call on health professionals to alert the public and our leaders to this major danger to public health and the e...
Source: JAMA Neurology - August 1, 2023 Category: Neurology Source Type: research

Outcomes and Treatment Approaches for Super-Refractory Status Epilepticus
This study attempts to assess clinical characteristics, causes, outcomes, prognostic factors, and treatment approaches for patients with super-refractory status epilepticus. (Source: JAMA Neurology)
Source: JAMA Neurology - July 31, 2023 Category: Neurology Source Type: research

Development and Validation of a Postprocedural Model to Predict Outcome After Endovascular Treatment for Ischemic Stroke
This prognostic study investigates the effectiveness of a prognostic tool to predict the functional outcome of individual patients after endovascular treatment for ischemic stroke. (Source: JAMA Neurology)
Source: JAMA Neurology - July 31, 2023 Category: Neurology Source Type: research

Prevalence and Implications of a β-Amyloid–Negative, Tau-Positive CSF Biomarker Profile in AD
This cohort study assesses the memory clinic prevalence and prognosis of individuals with a β-amyloid–negative, tau-positive cerebrospinal fluid biomarker profile. (Source: JAMA Neurology)
Source: JAMA Neurology - July 31, 2023 Category: Neurology Source Type: research

Considering Patient Sex in Prescribing CGRP Receptor Antagonists for Migraine
This Viewpoint describes the relevance of sex-specific differences in the treatment of migraine, including in evidence from trials of CGRP therapeutics, and the clinical implications for decision-making in practice and trial design. (Source: JAMA Neurology)
Source: JAMA Neurology - July 24, 2023 Category: Neurology Source Type: research

Exome Sequencing and the Identification of New Genes and Shared Mechanisms in Polymicrogyria
This genetic association study assesses germline genetic causes of polymicrogyria in a large cohort and considers novel polymicrogyria gene associations. (Source: JAMA Neurology)
Source: JAMA Neurology - July 24, 2023 Category: Neurology Source Type: research