An Integrated Interdisciplinary Sleep Care Model
This Viewpoint discusses the need for diverse physicians to manage sleep health. (Source: JAMA Neurology)
Source: JAMA Neurology - April 10, 2023 Category: Neurology Source Type: research

Association of Mortality and Risk of Epilepsy With Type of Acute Symptomatic Seizure After Ischemic Stroke
This cohort study examines data for patients with acute ischemic stroke to compare the risk of poststroke mortality and epilepsy between different types of acute symptomatic seizures. (Source: JAMA Neurology)
Source: JAMA Neurology - April 10, 2023 Category: Neurology Source Type: research

Efficacy and Safety of Avalglucosidase Alfa in Patients With Late-Onset Pompe Disease After 97 Weeks
This randomized clinical trial extension evaluates efficacy and safety outcomes of avalglucosidase alfa treatment in patients with late-onset Pompe disease. (Source: JAMA Neurology)
Source: JAMA Neurology - April 10, 2023 Category: Neurology Source Type: research

Severe Hippocampal Atrophy in Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy
This case report describes a patient who presented with headache, fever, quadriparesis, and reduced visual acuity in the left eye and 6 months later presented with persistent quadriparesis and new-onset cognitive deficits. (Source: JAMA Neurology)
Source: JAMA Neurology - April 10, 2023 Category: Neurology Source Type: research

Challenges and Opportunities for the Promising Biomarker Blood Neurofilament Light Chain
This Viewpoint describes the benefits and limitations of using neurofilament light chain (NfL) as a marker of real-time disease activity and treatment response in multiple sclerosis. (Source: JAMA Neurology)
Source: JAMA Neurology - April 3, 2023 Category: Neurology Source Type: research

Plasma P-Tau217 for Differentiation Between AD and FTLD Subtypes Among Patients With Corticobasal Syndrome
This cohort study evaluated the use phosphorylated tau217 to discern between Alzheimer disease and frontotemporal lobar degeneration among patients with corticobasal syndrome. (Source: JAMA Neurology)
Source: JAMA Neurology - April 3, 2023 Category: Neurology Source Type: research

Association of Age at Menopause and Hormone Therapy Use With Tau and β-Amyloid Positron Emission Tomography
This cross-sectional study examines the extent to which sex, age at menopause, and hormone therapy use are associated with regional tau at a given level of β-amyloid, both measured with positron emission tomography. (Source: JAMA Neurology)
Source: JAMA Neurology - April 3, 2023 Category: Neurology Source Type: research

Outcomes After Endovascular Therapy With Procedural Sedation vs General Anesthesia in Acute Ischemic Stroke
This randomized clinical trial evaluates whether general anesthesia or procedural sedation for anterior circulation large-vessel occlusion acute ischemic stroke thrombectomy are associated with a difference in periprocedural complications and 3-month functional outcome. (Source: JAMA Neurology)
Source: JAMA Neurology - April 3, 2023 Category: Neurology Source Type: research

Focal Cortex Stimulation With a Novel Implantable Device and Antiseizure Outcomes
This pooled analysis of 2 nonrandomized uncontrolled trials investigates the association between epicranial electrical focal cortex simulation and seizure frequency in drug-refractory focal epilepsy. (Source: JAMA Neurology)
Source: JAMA Neurology - April 3, 2023 Category: Neurology Source Type: research

Association Between Use of Angiotensin Receptor Blockers and Incidence of Epilepsy in Patients With Hypertension —Reply
In Reply We are grateful to Ryu and Kuo for their interesting and important comments on our publication, “Association Between Angiotensin Receptor Blocker Therapy and Incidence of Epilepsy in Patients with Hypertension.” The authors addressed several points in their letter. (Source: JAMA Neurology)
Source: JAMA Neurology - April 3, 2023 Category: Neurology Source Type: research

Association Between Use of Angiotensin Receptor Blockers and Incidence of Epilepsy in Patients With Hypertension
To the Editor It is with great pleasure that we read the retrospective study by Doege et al, which found a reduced incidence of epilepsy in patients with hypertension receiving angiotensin receptor blockers (ARBs) compared with other antihypertensives. The risk was highest among patients receiving β-blockers and calcium channel blockers (CCBs). (Source: JAMA Neurology)
Source: JAMA Neurology - April 3, 2023 Category: Neurology Source Type: research

JAMA Neurology
Mission Statement: The mission of JAMA Neurology is to publish and disseminate scientific information primarily important for physicians caring for people with neurologic disorders and for those interested in the structure and function of the normal and diseased human nervous system. The specific aims are to (1) publish timely original research, including clinical trials that will directly improve clinical neurologic care and that will inform efforts to improve neurological health and promote health care equity; (2) report translational research that is pertinent to the understanding of neurologic disease; (3) address topi...
Source: JAMA Neurology - April 1, 2023 Category: Neurology Source Type: research

Kidney Dysfunction, Blood Biomarkers of Alzheimer Disease, and Phosphorylated Tau to Total Tau Ratios
This cross-sectional study investigates associations of chronic kidney disease with plasma ratios of phosphorylated tau 217 and 181 to the corresponding unphosphorylated peptides in Alzheimer disease. (Source: JAMA Neurology)
Source: JAMA Neurology - March 29, 2023 Category: Neurology Source Type: research

Hello, My Name is Doctor
This essay describes a physician ’s opinion of why using only a first name can be confusing rather than aiding in resolving inequalities between physicians and other hospital staff or patients. (Source: JAMA Neurology)
Source: JAMA Neurology - March 27, 2023 Category: Neurology Source Type: research

Association of Dementia Risk With Focal Epilepsy and Modifiable Cardiovascular Risk Factors
This cross-sectional study examines data from the UK Biobank to explore the association between focal epilepsy compared with stroke or migraine and the risk of developing dementia and how that risk is affected by modifiable cardiovascular risk factors. (Source: JAMA Neurology)
Source: JAMA Neurology - March 27, 2023 Category: Neurology Source Type: research