Abandoning the Proteinopathy Paradigm in Parkinson Disease —Not So Fast—Reply

In Reply Decades of research have sought not to question but to prove that proteins can turn into toxins, with most efforts focusing on only one side of the protein aggregation story —the pathology. It is worth remembering that pathology today was a normal protein yesterday. In response to our Viewpoint, Bronstein and colleagues stated that “…lower CSF amyloid β actually correlates with brain amyloid accumulation….” Because the correlation is inverse, our “oversimpl ification” was to propose that the decrease in CSF amyloid β may be more relevant than the increase in amyloid.
Source: JAMA Neurology - Category: Neurology Source Type: research