Contribution of Somatic Ras/Raf/MAPK Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy
This genetic association study evaluates the association between pathogenic somatic variants in the hippocampus and mesial temporal lobe epilepsy. (Source: JAMA Neurology)
Source: JAMA Neurology - May 1, 2023 Category: Neurology Source Type: research
Oncogenic Pathways Provide Clue to the Etiology of Human Mesial Temporal Lobe Epilepsy
Consider this clinical scenario: A right-handed previously healthy male in his late 20s presents with a 15-year history of focal impaired awareness seizures manifesting at onset with an aura of rising gastric sensation followed by impaired awareness, unresponsiveness, repetitive chewing, and left-hand automatisms of picking at his clothes. After a seizure, he is confused and tired. His events occur weekly and typically in a cluster despite a combination therapy with 3 antiseizure medications. Recent 3-T brain imaging showed signal changes consistent with hippocampal sclerosis, and a 24-hour ambulatory electroencephalograph...
Source: JAMA Neurology - May 1, 2023 Category: Neurology Source Type: research
Trends in the Prevalence of Stroke Among Community-Dwelling Individuals in the US, 1999-2018
This cross-sectional study estimates trends in stroke prevalence representative of the noninstitutionalized civilian population of US adults 20 years and older using data from the 1999 to 2018 National Health and Nutrition Examination Surveys. (Source: JAMA Neurology)
Source: JAMA Neurology - April 24, 2023 Category: Neurology Source Type: research
Advocating for Demonstration of Disease Modification in Trials of Drugs for Early AD
This Viewpoint discusses the benefits of clinical trials with a delayed-start design and analysis of downstream biomarkers to examine whether antimyeloid immunotherapy changes the course of early Alzheimer disease. (Source: JAMA Neurology)
Source: JAMA Neurology - April 24, 2023 Category: Neurology Source Type: research
Characteristics of Progressive Multifocal Leukoencephalopathy Associated With Sarcoidosis
This case series examines data for patients from 8 US medical centers to determine and describe the characteristics associated with progressive multifocal leukoencephalopathy in the context of sarcoidosis, including neurological symptoms and changes seen on brain magnetic resonance imaging. (Source: JAMA Neurology)
Source: JAMA Neurology - April 24, 2023 Category: Neurology Source Type: research
Ultrasonography of Muscle Vibration Caused by MYBPC1 Variant
This case report describes muscle vibration during muscle contraction caused by an MYBPC1 variant. (Source: JAMA Neurology)
Source: JAMA Neurology - April 24, 2023 Category: Neurology Source Type: research
Incorporating the Central Vein Sign Into the Diagnostic Criteria for Multiple Sclerosis
This Viewpoint discusses incorporating the central vein sign into the diagnostic criteria for multiple sclerosis. (Source: JAMA Neurology)
Source: JAMA Neurology - April 17, 2023 Category: Neurology Source Type: research
Glycemic Control Over Multiple Decades and Dementia Risk in People With Type 2 Diabetes
This cohort study examines associations between cumulative exposure to various ranges of glycated hemoglobin concentrations and dementia risk among adults aged 50 years or older with type 2 diabetes. (Source: JAMA Neurology)
Source: JAMA Neurology - April 17, 2023 Category: Neurology Source Type: research
Prenatal Exposure to Antiseizure Medication and Psychiatric Disorders
This cohort study of children of mothers with epilepsy examines whether prenatal exposure to common prenatal antiseizure medication is associated with a broad spectrum of psychiatric disorders in childhood and adolescence. (Source: JAMA Neurology)
Source: JAMA Neurology - April 17, 2023 Category: Neurology Source Type: research
Lentiform Fork Sign on Magnetic Resonance Imaging After Methamphetamine and Alcohol Misuse
This case report describes a patient with a 3-day history of acute blindness after using alcohol and methamphetamine for 3 consecutive nights before onset of visual impairment. (Source: JAMA Neurology)
Source: JAMA Neurology - April 17, 2023 Category: Neurology Source Type: research
An Integrated Interdisciplinary Sleep Care Model
This Viewpoint discusses the need for diverse physicians to manage sleep health. (Source: JAMA Neurology)
Source: JAMA Neurology - April 10, 2023 Category: Neurology Source Type: research
Association of Mortality and Risk of Epilepsy With Type of Acute Symptomatic Seizure After Ischemic Stroke
This cohort study examines data for patients with acute ischemic stroke to compare the risk of poststroke mortality and epilepsy between different types of acute symptomatic seizures. (Source: JAMA Neurology)
Source: JAMA Neurology - April 10, 2023 Category: Neurology Source Type: research
Efficacy and Safety of Avalglucosidase Alfa in Patients With Late-Onset Pompe Disease After 97 Weeks
This randomized clinical trial extension evaluates efficacy and safety outcomes of avalglucosidase alfa treatment in patients with late-onset Pompe disease. (Source: JAMA Neurology)
Source: JAMA Neurology - April 10, 2023 Category: Neurology Source Type: research
Severe Hippocampal Atrophy in Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy
This case report describes a patient who presented with headache, fever, quadriparesis, and reduced visual acuity in the left eye and 6 months later presented with persistent quadriparesis and new-onset cognitive deficits. (Source: JAMA Neurology)
Source: JAMA Neurology - April 10, 2023 Category: Neurology Source Type: research
Challenges and Opportunities for the Promising Biomarker Blood Neurofilament Light Chain
This Viewpoint describes the benefits and limitations of using neurofilament light chain (NfL) as a marker of real-time disease activity and treatment response in multiple sclerosis. (Source: JAMA Neurology)
Source: JAMA Neurology - April 3, 2023 Category: Neurology Source Type: research
