JAMA Neurology
Mission Statement: The mission of JAMA Neurology is to publish and disseminate scientific information primarily important for physicians caring for people with neurologic disorders and for those interested in the structure and function of the normal and diseased human nervous system. The specific aims are to (1) publish timely original research, including clinical trials that will directly improve clinical neurologic care and that will inform efforts to improve neurological health and promote health care equity; (2) report translational research that is pertinent to the understanding of neurologic disease; (3) address topi...
Source: JAMA Neurology - January 1, 2024 Category: Neurology Source Type: research

Error in Table 4
This article has been corrected. (Source: JAMA Neurology)
Source: JAMA Neurology - January 1, 2024 Category: Neurology Source Type: research

Error in Key for Figure 3
In the Original Investigation titled “Plasma Biomarker Strategy for Selecting Patients With Alzheimer Disease for Antiamyloid Immunotherapies,” which was published Online First on December 4, 2023, the amyloid β–positive groups were labeled incorrectly in the key for Figure 3. The article was corrected online. (Source: JAMA Neurology)
Source: JAMA Neurology - January 1, 2024 Category: Neurology Source Type: research

Looking Beyond Syndrome-Based Criteria for Autoimmune Encephalitis
This Viewpoint discusses how neural antibody –based diagnostic criteria for autoimmune encephalitis would complement the syndrome-based diagnostic algorithm to improve sensitivity while maintaining high specificity. (Source: JAMA Neurology)
Source: JAMA Neurology - December 26, 2023 Category: Neurology Source Type: research

Risk Factors for Young-Onset Dementia in the UK Biobank
This cohort study examines factors that are associated with the incidence of young-onset dementia among UK Biobank participants. (Source: JAMA Neurology)
Source: JAMA Neurology - December 26, 2023 Category: Neurology Source Type: research

Cerebral Amyloid Angiopathy and Risk of Isolated Nontraumatic Subdural Hemorrhage
This cohort study of participants in the UK Biobank cohort and the All of Us Research Program cohort investigates whether cerebral amyloid angiopathy is an independent risk factor for isolated nontraumatic subdural hemorrhage. (Source: JAMA Neurology)
Source: JAMA Neurology - December 26, 2023 Category: Neurology Source Type: research

Retinal Hemorrhage Associated with Human Granulocytic Anaplasmosis
This case report describes a 51-year-old female with presented to the emergency department with high-grade fever, headache, nausea, vomiting, dizziness, diffuse arthralgias, and new-onset worsened vision that had developed over 3 days. (Source: JAMA Neurology)
Source: JAMA Neurology - December 26, 2023 Category: Neurology Source Type: research

Direct to Consumer Biomarker Testing for Alzheimer Disease —Are We Ready for the Insurance Consequences?
This Viewpoint discusses direct-to-consumer biomarker tests for Alzheimer disease and their implications on future insurance coverage. (Source: JAMA Neurology)
Source: JAMA Neurology - December 18, 2023 Category: Neurology Source Type: research

Hypothermia vs Normothermia in Patients With Cardiac Arrest and Nonshockable Rhythm
This study attempts to assess whether hypothermia at 33 °C increases survival and improves function when compared with controlled normothermia in unconscious adults resuscitated from out-of-hospital cardiac arrest with initial nonshockable rhythm. (Source: JAMA Neurology)
Source: JAMA Neurology - December 18, 2023 Category: Neurology Source Type: research

Neprilysin Inhibition for Alzheimer Disease
This exploratory analysis of a randomized clinical trial evaluates the effect of neprilysin inhibition on Alzheimer disease blood biomarkers in patients with heart disease. (Source: JAMA Neurology)
Source: JAMA Neurology - December 18, 2023 Category: Neurology Source Type: research

Hypothermia to 33 °C Following Cardiac Arrest
For more than 20 years, since the widespread introduction of therapeutic hypothermia to critical care, questions remain regarding whether certain patients benefit from targeted temperature management (TTM) following cardiac arrest. Early studies suggested improved outcomes with TTM to 33 °C; however, these had significant methodological limitations, including small sample sizes, lack of blinding and standardized neuroprognostication, and inadequate fever management in control groups. Furthermore, inclusion criteria allowed for enrollment of only shockable rhythms. Improving on thes e early investigations were the TTM stud...
Source: JAMA Neurology - December 18, 2023 Category: Neurology Source Type: research

A 51-Year-Old Woman With Abnormal Corpus Callosum Signal
A 51-year-old woman presented with a 2-year history of progressive memory loss and left limb numbness. Imaging showed multifocal restricted diffusion in the corpus callosum and diffuse subcortical white matter hyperintensities and corpus callosum atrophy. What is your diagnosis? (Source: JAMA Neurology)
Source: JAMA Neurology - December 18, 2023 Category: Neurology Source Type: research

Ownership and Interoperability Challenges of Alzheimer Monoclonal Antibody Registries
This Viewpoint addresses the challenges that the Centers for Medicare and Medicaid Services faces to collect real-world data on the effectiveness and safety of lecanemab from external registries to achieve its coverage with evidence development objectives. (Source: JAMA Neurology)
Source: JAMA Neurology - December 11, 2023 Category: Neurology Source Type: research

How Much Good I Can Afford
This essay describes the author ’s experience balancing the different necessities in medical practice, in particular writing perfect patient notes vs establishing a face-to-face connection. (Source: JAMA Neurology)
Source: JAMA Neurology - December 11, 2023 Category: Neurology Source Type: research

Diagnostic Performance of Cortical Lesions and the Central Vein Sign in MS
This cross-sectional study evaluates the use of cortical lesions and central vein sign in distinguishing multiple sclerosis from other conditions. (Source: JAMA Neurology)
Source: JAMA Neurology - December 11, 2023 Category: Neurology Source Type: research