Magnetic Resonance Imaging Features of Encephalitis of Scrub Typhus
This case report describes the magnetic resonance imaging (MRI) findings and diagnosis of scrub typhus infection in a woman who had recurrent high fever, akinetic mutism, an eschar, and an increase in lymphocytes. (Source: JAMA Neurology)
Source: JAMA Neurology - March 25, 2024 Category: Neurology Source Type: research

Improving Trends in Brain Health Explain Declining Dementia Risk?
The passage of the 20th century has seen dramatic improvements in standard of living, education, and health care in the world. These societal changes have been suggested to have contributed to stable and declining dementia incidence and prevalence rates in the Western countries. Brain health, reflective of a wide spectrum of factors, including early brain development and environment influences, lifestyle, and education levels, may be one of the key pathways explaining this decline in dementia risk. Emerging multidomain trials for improving brain health to reduce dementia risk provide support for this hypothesis. However, t...
Source: JAMA Neurology - March 25, 2024 Category: Neurology Source Type: research

JAMA Neurology Peer Reviewers in 2023
We sincerely thank the 709 peer reviewers who completed manuscript reviews for JAMA Neurology in 2023. (Source: JAMA Neurology)
Source: JAMA Neurology - March 18, 2024 Category: Neurology Source Type: research

The Most Difficult Question in a Cognitive Disorders Clinic
This essay describes the difficulty in diagnosing dementia and the experiences and questions caregivers have regarding its diagnosis. (Source: JAMA Neurology)
Source: JAMA Neurology - March 18, 2024 Category: Neurology Source Type: research

Serologic Response to Epstein-Barr Virus Peptidome and Multiple Sclerosis Risk
This case-control study assesses the serologic response to the Epstein-Barr virus peptidome before first symptoms of multiple sclerosis occur and whether specific epitopes may drive this response. (Source: JAMA Neurology)
Source: JAMA Neurology - March 18, 2024 Category: Neurology Source Type: research

Risk of Major Congenital Malformations and Exposure to Antiseizure Medication Monotherapy
This cohort study investigates the risk of major congenital malformations associated with antiseizure medication (ASM) monotherapy in the offspring of mothers taking ASMs during pregnancy. (Source: JAMA Neurology)
Source: JAMA Neurology - March 18, 2024 Category: Neurology Source Type: research

Magnetic Resonance Imaging Characteristics of LGI1-Antibody and CASPR2-Antibody Encephalitis
This cross-sectional study examines findings from brain magnetic resonance imaging to identify the characteristics than can distinguish LGI1-antibody and CASPR2-antibody autoimmune encephalitis from viral encephalitis and Creutzfeldt-Jakob disease (Source: JAMA Neurology)
Source: JAMA Neurology - March 18, 2024 Category: Neurology Source Type: research

Discussion on the Application of Rapid Immunoblot Assay for AQP4-IgG Detection —Reply
In Reply We thank Su and Wang for their valuable insights of our recent article on the rapid immunodot aquaporin 4 (AQP4) assay for neuromyelitis optica spectrum disorder (NMOSD). (Source: JAMA Neurology)
Source: JAMA Neurology - March 18, 2024 Category: Neurology Source Type: research

Discussion on the Application of Rapid Immunoblot Assay for AQP4-IgG Detection
To the Editor We read with great interest the research finding by Fu et al, which presents a novel immunodot assay that is both highly efficient and user friendly for the detection of aquaporin 4 (AQP4) immunoglobulin G (IgG). The development of this assay holds significant importance in advancing early and accurate diagnosis of neuromyelitis optica spectrum disorder (NMOSD). However, after reading this article, we would like to highlight several questions of interest. (Source: JAMA Neurology)
Source: JAMA Neurology - March 18, 2024 Category: Neurology Source Type: research

Visualizing Hyperhidrosis With Water-Erasable Ink
This case report describes the use of water-erasable ink to visualize hyperhidrosis in Frey syndrome. (Source: JAMA Neurology)
Source: JAMA Neurology - March 18, 2024 Category: Neurology Source Type: research

The Year in Review, 2023
As we turn the page on 2023, we here at JAMA Neurology want to once again thank all of our readers, authors, and peer reviewers (who are listed elsewhere) for their continued support and contributions. Over the 7 years that our team has been fortunate enough to steward this amazing publication, our editorial team has overseen a transformation of the journal, with an eye toward incorporating your feedback to better meet your needs. (Source: JAMA Neurology)
Source: JAMA Neurology - March 18, 2024 Category: Neurology Source Type: research

Treatment of Refractory Status Epilepticus With Continuous Intravenous Anesthetic Drugs
This systematic review investigates the association between choice of initial continuous intravenous anesthetic drug and treatment failure, adverse events, and mortality in patients with refractory status epilepticus. (Source: JAMA Neurology)
Source: JAMA Neurology - March 11, 2024 Category: Neurology Source Type: research

Clopidogrel Plus Aspirin vs Aspirin Alone in Patients With Acute Mild to Moderate Stroke
This randomized clinical trial evaluates the use of dual vs single antiplatelet therapy in the treatment of patients with mild to moderate ischemic stroke. (Source: JAMA Neurology)
Source: JAMA Neurology - March 11, 2024 Category: Neurology Source Type: research

Emerging Cerebrospinal Fluid Biomarkers of Disease Activity and Progression in Multiple Sclerosis
This cohort study examines data from 2 prospective multiple sclerosis cohorts to identify cerebrospinal fluid measures associated with relapsing and nonrelapsing progressive multiple sclerosis pathobiology. (Source: JAMA Neurology)
Source: JAMA Neurology - March 11, 2024 Category: Neurology Source Type: research

Microbleeds in Heterozygous HTRA1 -Related Cerebral Small Vessel Disease
This case report describes the evaluation of a 44-year-old man with a history of headache, dizziness, and imbalance and imaging that showed lacunar infarctions and bilateral white matter hyperintensities. (Source: JAMA Neurology)
Source: JAMA Neurology - March 11, 2024 Category: Neurology Source Type: research