A Step Forward in the Fight Against Dementia
This Viewpoint reports on the results of the Clarity AD trial, a phase 3 randomized clinical trial of lecanemab for patients with early Alzheimer disease, in which lecanemab ’s clinical efficacy was demonstrated using well-established outcome measures. (Source: JAMA Neurology)
Source: JAMA Neurology - March 13, 2023 Category: Neurology Source Type: research

Physical Frailty, Genetic Predisposition, and Incident Parkinson Disease
This cohort study attempts to examine the longitudinal association of frailty phenotype with the development of Parkinson disease and to explore the modification role of genetic risk of Parkinson disease in such association. (Source: JAMA Neurology)
Source: JAMA Neurology - March 13, 2023 Category: Neurology Source Type: research

Perinatal Outcomes for Women With and Without Epilepsy
This systematic review and meta-analysis compares data for women with and without epilepsy to investigate maternal, fetal, and neonatal complications and their associations with epilepsy and use of antiseizure medications. (Source: JAMA Neurology)
Source: JAMA Neurology - March 13, 2023 Category: Neurology Source Type: research

Multimodal Neuroimaging of Intimal Flap in a Basilar Artery Dissection
This case report describes a spontaneous dissection of the basilar artery in a 53-year-old man presenting with ischemic stroke. (Source: JAMA Neurology)
Source: JAMA Neurology - March 13, 2023 Category: Neurology Source Type: research

Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac Arrest
This case-control study evaluates the potential role of blood phosphorylated tau and amyloid- β peptides in neurological prognostication following cardiac arrest. (Source: JAMA Neurology)
Source: JAMA Neurology - March 6, 2023 Category: Neurology Source Type: research