Advocating for Demonstration of Disease Modification in Trials of Drugs for Early AD
This Viewpoint discusses the benefits of clinical trials with a delayed-start design and analysis of downstream biomarkers to examine whether antimyeloid immunotherapy changes the course of early Alzheimer disease. (Source: JAMA Neurology)
Source: JAMA Neurology - April 24, 2023 Category: Neurology Source Type: research

Characteristics of Progressive Multifocal Leukoencephalopathy Associated With Sarcoidosis
This case series examines data for patients from 8 US medical centers to determine and describe the characteristics associated with progressive multifocal leukoencephalopathy in the context of sarcoidosis, including neurological symptoms and changes seen on brain magnetic resonance imaging. (Source: JAMA Neurology)
Source: JAMA Neurology - April 24, 2023 Category: Neurology Source Type: research

Ultrasonography of Muscle Vibration Caused by MYBPC1 Variant
This case report describes muscle vibration during muscle contraction caused by an MYBPC1 variant. (Source: JAMA Neurology)
Source: JAMA Neurology - April 24, 2023 Category: Neurology Source Type: research

Incorporating the Central Vein Sign Into the Diagnostic Criteria for Multiple Sclerosis
This Viewpoint discusses incorporating the central vein sign into the diagnostic criteria for multiple sclerosis. (Source: JAMA Neurology)
Source: JAMA Neurology - April 17, 2023 Category: Neurology Source Type: research

Glycemic Control Over Multiple Decades and Dementia Risk in People With Type 2 Diabetes
This cohort study examines associations between cumulative exposure to various ranges of glycated hemoglobin concentrations and dementia risk among adults aged 50 years or older with type 2 diabetes. (Source: JAMA Neurology)
Source: JAMA Neurology - April 17, 2023 Category: Neurology Source Type: research

Prenatal Exposure to Antiseizure Medication and Psychiatric Disorders
This cohort study of children of mothers with epilepsy examines whether prenatal exposure to common prenatal antiseizure medication is associated with a broad spectrum of psychiatric disorders in childhood and adolescence. (Source: JAMA Neurology)
Source: JAMA Neurology - April 17, 2023 Category: Neurology Source Type: research

Lentiform Fork Sign on Magnetic Resonance Imaging After Methamphetamine and Alcohol Misuse
This case report describes a patient with a 3-day history of acute blindness after using alcohol and methamphetamine for 3 consecutive nights before onset of visual impairment. (Source: JAMA Neurology)
Source: JAMA Neurology - April 17, 2023 Category: Neurology Source Type: research

An Integrated Interdisciplinary Sleep Care Model
This Viewpoint discusses the need for diverse physicians to manage sleep health. (Source: JAMA Neurology)
Source: JAMA Neurology - April 10, 2023 Category: Neurology Source Type: research

Association of Mortality and Risk of Epilepsy With Type of Acute Symptomatic Seizure After Ischemic Stroke
This cohort study examines data for patients with acute ischemic stroke to compare the risk of poststroke mortality and epilepsy between different types of acute symptomatic seizures. (Source: JAMA Neurology)
Source: JAMA Neurology - April 10, 2023 Category: Neurology Source Type: research

Efficacy and Safety of Avalglucosidase Alfa in Patients With Late-Onset Pompe Disease After 97 Weeks
This randomized clinical trial extension evaluates efficacy and safety outcomes of avalglucosidase alfa treatment in patients with late-onset Pompe disease. (Source: JAMA Neurology)
Source: JAMA Neurology - April 10, 2023 Category: Neurology Source Type: research

Severe Hippocampal Atrophy in Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy
This case report describes a patient who presented with headache, fever, quadriparesis, and reduced visual acuity in the left eye and 6 months later presented with persistent quadriparesis and new-onset cognitive deficits. (Source: JAMA Neurology)
Source: JAMA Neurology - April 10, 2023 Category: Neurology Source Type: research

Challenges and Opportunities for the Promising Biomarker Blood Neurofilament Light Chain
This Viewpoint describes the benefits and limitations of using neurofilament light chain (NfL) as a marker of real-time disease activity and treatment response in multiple sclerosis. (Source: JAMA Neurology)
Source: JAMA Neurology - April 3, 2023 Category: Neurology Source Type: research

Plasma P-Tau217 for Differentiation Between AD and FTLD Subtypes Among Patients With Corticobasal Syndrome
This cohort study evaluated the use phosphorylated tau217 to discern between Alzheimer disease and frontotemporal lobar degeneration among patients with corticobasal syndrome. (Source: JAMA Neurology)
Source: JAMA Neurology - April 3, 2023 Category: Neurology Source Type: research

Association of Age at Menopause and Hormone Therapy Use With Tau and β-Amyloid Positron Emission Tomography
This cross-sectional study examines the extent to which sex, age at menopause, and hormone therapy use are associated with regional tau at a given level of β-amyloid, both measured with positron emission tomography. (Source: JAMA Neurology)
Source: JAMA Neurology - April 3, 2023 Category: Neurology Source Type: research

Outcomes After Endovascular Therapy With Procedural Sedation vs General Anesthesia in Acute Ischemic Stroke
This randomized clinical trial evaluates whether general anesthesia or procedural sedation for anterior circulation large-vessel occlusion acute ischemic stroke thrombectomy are associated with a difference in periprocedural complications and 3-month functional outcome. (Source: JAMA Neurology)
Source: JAMA Neurology - April 3, 2023 Category: Neurology Source Type: research