Histologic Anatomy of Neurocysticercosis
This case report describes a 23-year-old male patient with tonic-clonic seizure and subsequent treatment with anthelmintic therapy. (Source: JAMA Neurology)
Source: JAMA Neurology - October 23, 2023 Category: Neurology Source Type: research
Progressive Cranial Neuropathy
A 68-year-old man had right facial weakness with a droop, slurred speech, and eyelid ptosis that progressed over 5 years from right temple numbness and did not respond to gabapentin or steroids. What is your diagnosis? (Source: JAMA Neurology)
Source: JAMA Neurology - October 23, 2023 Category: Neurology Source Type: research
A New Framework for Dementia Nomenclature
This Special Communication describes the need for a systematic neurodegenerative disease framework for information collection and communication to standardize dementia nomenclature usage for research, clinical, and public health purposes. (Source: JAMA Neurology)
Source: JAMA Neurology - October 16, 2023 Category: Neurology Source Type: research
I Do Care
This essay recalls the importance of compassion in medicine. (Source: JAMA Neurology)
Source: JAMA Neurology - October 16, 2023 Category: Neurology Source Type: research
White Matter Hyperintensities in Alzheimer Disease
This cohort study investigates whether white matter hyperintensity in individuals with Alzheimer disease is more likely to be associated with neurodegeneration and parenchymal and vessel amyloidosis than with systemic vascular risk. (Source: JAMA Neurology)
Source: JAMA Neurology - October 16, 2023 Category: Neurology Source Type: research
Ongoing Challenges in the Diagnosis of MOGAD
This cross-sectional study examines whether proposed myelin oligodendrocyte glycoprotein antibody –associated disease (MOGAD) diagnostic criteria can exclude other diseases, such as multiple sclerosis, and rely on results of cell-based assays. (Source: JAMA Neurology)
Source: JAMA Neurology - October 10, 2023 Category: Neurology Source Type: research
Efficacy and Safety of XEN1101 in Adults With Focal Epilepsy
This randomized clinical trial evaluates the efficacy and safety of XEN1101, a potassium channel opener, in the treatment of adults with intractable focal-onset seizures. (Source: JAMA Neurology)
Source: JAMA Neurology - October 9, 2023 Category: Neurology Source Type: research
Tau Oligomer –Containing Synapses Engulfed by Microglia and Astrocytes in Alzheimer Disease
This cross-sectional study assesses whether synapses containing tau oligomers are excessively eliminated by microglia and astrocytes in brains of individuals with vs without dementia but similar neuropathologic changes at autopsy suggestive of early clinical stages of Alzheimer disease. (Source: JAMA Neurology)
Source: JAMA Neurology - October 9, 2023 Category: Neurology Source Type: research
A Nonrandomized Controlled TrialAmyloid PET and Subsequent Health Care Use Among Medicare Beneficiaries
This nonrandomized controlled trial compares rates of inpatient hospitalizations and emergency department visits between Medicare beneficiaries with cognitive decline who participated in the Imaging Dementia –Evidence for Amyloid Scanning study vs Medicare beneficiaries who had not undergone amyloid positron emission tomography. (Source: JAMA Neurology)
Source: JAMA Neurology - October 9, 2023 Category: Neurology Source Type: research
Intraspinal Bone Fragments Resorption in Thoracolumbar Burst Fracture
This case report describes a man in his 30s transported to a surgical ward with a 7-hour history of unintentional fall from over 20 m. (Source: JAMA Neurology)
Source: JAMA Neurology - October 9, 2023 Category: Neurology Source Type: research
JAMA Neurology Editorial Fellow
We are pleased to announce that JAMA Neurology is offering a 1-year editorial fellowship position for a qualified individual. The fellow will receive hands-on training in the editorial processes and policies of a neurology journal and will be well prepared to take an editorial role in a peer-reviewed publication at the end of the fellowship. (Source: JAMA Neurology)
Source: JAMA Neurology - October 9, 2023 Category: Neurology Source Type: research
Synaptic Oligomers and Glial Cells in Alzheimer Disease
Alzheimer disease (AD) presents an intricate puzzle for researchers and clinicians, with synaptic and neuronal degeneration at the core of its associated cognitive decline. Despite the prominence of the amyloid- β (Aβ) cascade in the AD narrative, attempts to curb disease advancement by eliminating amyloid plaques have yielded limited clinical success. Neurofibrillary tangles, the other hallmark of AD neuropathology, correlate more closely with the loss of synapses and neurons than does Aβ. This evidence highlights the significance of tau alterations associated with the development of AD although the precise mechanisms ...
Source: JAMA Neurology - October 9, 2023 Category: Neurology Source Type: research
Harmonizing Definitions for Progression Independent of Relapse Activity in Multiple Sclerosis
This systematic review summarizes the current evidence about progression independent of relapse activity (PIRA) based on a systematic review, discuses the various terminologies used in the context of PIRA, and proposes a harmonized definition for PIRA for use in clinical practice and future trials. (Source: JAMA Neurology)
Source: JAMA Neurology - October 2, 2023 Category: Neurology Source Type: research
Levetiracetam vs Lamotrigine as First-Line Antiseizure Medication in Female Patients With Idiopathic Generalized Epilepsy
This comparative effectiveness study investigates the comparative effectiveness of levetiracetam and lamotrigine as initial antiseizure medication in female patients of childbearing age with idiopathic generalized epilepsy. (Source: JAMA Neurology)
Source: JAMA Neurology - October 2, 2023 Category: Neurology Source Type: research
Loneliness and Risk of Parkinson Disease
This cohort study uses data from the UK Biobank to assess the association of loneliness with the risk of incident Parkinson disease. (Source: JAMA Neurology)
Source: JAMA Neurology - October 2, 2023 Category: Neurology Source Type: research
