Current and future of immunotherapy for thyroid cancer based on bibliometrics and clinical trials
ConclusionThe study's dual approach verifies the swift advancement of thyroid cancer immunotherapy from diverse perspectives. Immune checkpoint inhibitors have become the preferred regimen for advanced MTC and ATC in late therapeutic lines. However, since ICB plays a pivotal role in ATC, current clinical trial data show that ATC patients account for more and the curative effect is more accurate. Anticipated future developments are inclined toward combination regimens integrating immunotherapy with chemotherapy or targeted therapies. Emerging approaches, such as bispecific antibodies, cytokine-based therapies, and adoptive ...
Source: Hormones and Cancer - February 25, 2024 Category: Cancer & Oncology Source Type: research
Comprehensive pan-carcinoma analysis of ITGB1 distortion and its potential clinical significance for cancer immunity
AbstractThe human protein-coding gene ITGB1 (Integrin 1), also known as CD29, has a length of 58048 base pairs. The Integrin family's most prevalent subunit, it participates in the transmission of numerous intracellular signaling pathways. A thorough examination of ITGB1's functions in human malignancies, however, is inadequate and many of their relationships to the onset and development of human cancers remain unknown. In this work, we examined ITGB1's role in 33 human cancers. Finally, a multi-platform analysis revealed that three of the 33 malignancies had significantly altered ITGB1 expression in tumor tissues in compa...
Source: Hormones and Cancer - February 24, 2024 Category: Cancer & Oncology Source Type: research
Modulation of intestinal metabolites by calorie restriction and its association with gut microbiota in a xenograft model of colorectal cancer
ConclusionCalorie restriction affects the abundance of gut microbes such asNitrospirae phylum andLactobacillus genus in mouse model of colorectal cancer, leading to changes in the metabolites such as D-Proline 、Isoleucyl-Valine, which contributes to the suppression of in vivo growth of CRC by calorie restriction. (Source: Hormones and Cancer)
Source: Hormones and Cancer - February 22, 2024 Category: Cancer & Oncology Source Type: research
TRAIL predisposes non-small cell lung cancer to ferroptosis by regulating ASK-1/JNK1 pathway
ConclusionWe indicated that overexpression of TRAIL induced ferroptosis in NSCLC cells and exerted anti-tumor effects. Mechanistically, TRAIL promoted ferroptosis by the activation of the ASK-1/JNK1 pathway. Our results may provide new therapeutic strategies for NSCLC. (Source: Hormones and Cancer)
Source: Hormones and Cancer - February 21, 2024 Category: Cancer & Oncology Source Type: research
Should we consider Systemic Inflammatory Response Index (SIRI) as a new diagnostic marker for rectal cancer?
ConclusionSIRI may be a valuable diagnostic marker in rectal cancer patients. Higher SIRI levels were also associated with poorer prognosis and increased complication rates. Still, further prospective studies with a larger number of patients are needed. (Source: Hormones and Cancer)
Source: Hormones and Cancer - February 21, 2024 Category: Cancer & Oncology Source Type: research
Identifying the tumor immune microenvironment-associated prognostic genes for prostate cancer
ConclusionsThis study identified three TIME-related genes, namely,METTL7B,HOXB8, andTREM1, which correlated with the prognosis of patients with PRAD. Targeting the TIME-related genes might have important clinical implications when making decisions for immunotherapy in PRAD. (Source: Hormones and Cancer)
Source: Hormones and Cancer - February 20, 2024 Category: Cancer & Oncology Source Type: research
Concomitant double-fusion of PLEKHA7-ALK and INPP5D-ALK reveals favorable alectinib sensitivity in lung adenocarcinoma: a case report and literature review
In this study, we reported a case with extremely uncommonALK double-fusion variants. A 32-year-old female diagnosed with lung adenocarcinoma, who had developed multiple intrapulmonary and brain metastases, experienced worsening of her condition despite undergoing prior chemotherapy. Subsequent testing using next-generation sequencing (NGS) detected the presence ofPLEKHA7-ALK andINPP5D-ALK double-fusion. The prescription of alectinib revealed potent efficacy and resulted in an increase in the survival rate. This case presented two uncommon and concomitantALK fusion partners in NSCLC; more importantly, theINPP5D-ALK subtype ...
Source: Hormones and Cancer - February 20, 2024 Category: Cancer & Oncology Source Type: research
Delineating the role of nuclear receptors in colorectal cancer, a focused review
AbstractColorectal cancer (CRC) stands as one of the most prevalent form of cancer globally, causing a significant number of deaths, surpassing 0.9 million in the year 2020. According to GLOBOCAN 2020, CRC ranks third in incidence and second in mortality in both males and females. Despite extensive studies over the years, there is still a need to establish novel therapeutic targets to enhance the patients ’ survival rate in CRC. Nuclear receptors (NRs) are ligand-activated transcription factors (TFs) that regulate numerous essential biological processes such as differentiation, development, physiology, reproduction, and ...
Source: Hormones and Cancer - February 19, 2024 Category: Cancer & Oncology Source Type: research
Feasibility analysis of arterial CT radiomics model to predict the risk of local and metastatic recurrence after radical cystectomy for bladder cancer
ConclusionThe radiomics-clinical nomogram model constructed based on the radiomics features of arterial CT images and important clinical risk factors is potentially feasible for predicting the risk of recurrence within 3 years after RC for BCa. (Source: Hormones and Cancer)
Source: Hormones and Cancer - February 19, 2024 Category: Cancer & Oncology Source Type: research
Histological types of brain tumors diagnosed at the Kenyatta National Hospital between 2016 and 2019: a retrospective study
ConclusionThis study highlights the existing burden of brain tumors in Kenya and data from KNH may be representative of the national burden of BTs. This study lays a foundation for subsequent clinical and epidemiological studies and emphasizes the need to adopt existing reporting standards to help realize a complete picture of the burden of brain tumors in Kenya. (Source: Hormones and Cancer)
Source: Hormones and Cancer - February 18, 2024 Category: Cancer & Oncology Source Type: research
Real-world prognostic significance of attaining minimal residual disease negativity in newly diagnosed multiple myeloma
We examined MRD status by multiparameter flow cytometry (MFC). At a median follow-up of 37 months (4–88 months), In patients who achieved ≥ VGPR, those with MRD negativity had significantly longer PFS (51vs. 26 months;P < 0.001) and OS (Not reached: NRvs. 62 months,P < 0.001) than those with MRD positivity. MRD positivity was the independent prognostic factor for PFS with hazard ratios of 2.650 (95% CI 1.755–4.033,P < 0.001) and OS with hazard ratios of 2.122 (95% CI 1.155–3.899,P = 0.015). Achieving MRD negativity was able to ameliorate a poor prognosis associated with geneti...
Source: Hormones and Cancer - February 17, 2024 Category: Cancer & Oncology Source Type: research
The endoplasmic reticulum stress-related genes and molecular typing predicts prognosis and reveals characterization of tumor immune microenvironment in lung squamous cell carcinoma
ConclusionERS-related risk signature has certain prognostic value and may be a potential therapeutic target and prognostic biomarker for LUSC patients. (Source: Hormones and Cancer)
Source: Hormones and Cancer - February 16, 2024 Category: Cancer & Oncology Source Type: research
Expression of FOXI1 and POU2F3 varies among different salivary gland neoplasms and is higher in Warthin tumor
ConclusionThe expression patterns of the characteristic transcription factors found in ionocytes and tuft cells vary among salivary gland tumor types and are higher in WT, which might be relevant for understanding and diagnosing salivary gland neoplasms. (Source: Hormones and Cancer)
Source: Hormones and Cancer - February 15, 2024 Category: Cancer & Oncology Source Type: research
A novel prognostic model of breast cancer based on cuproptosis-related lncRNAs
ConclusionsThe model established in this study based on cuproptosis-related lncRNAs may be capable of improving the OS of patients with BC. (Source: Hormones and Cancer)
Source: Hormones and Cancer - February 14, 2024 Category: Cancer & Oncology Source Type: research
Analysis of factors related to osteoporotic vertebral fracture in prostate cancer patients
ConclusionOsteoporotic vertebral fractures in patients with prostate cancer was associated with many factors. And the incidence of vertebral fracture in prostate cancer patients after ADT was significantly higher than that before treatment. (Source: Hormones and Cancer)
Source: Hormones and Cancer - February 13, 2024 Category: Cancer & Oncology Source Type: research
