Circulating tumor cells clusters and their role in Breast cancer metastasis; a review of literature
AbstractBreast cancer is a significant and deadly threat to women globally. Moreover, Breast cancer metastasis is a complicated process involving multiple biological stages, which is considered a substantial cause of death, where cancer cells spread from the original tumor to other organs in the body —representing the primary mortality factor. Circulating tumor cells (CTCs) are cancer cells detached from the primary or metastatic tumor and enter the bloodstream, allowing them to establish new metastatic sites. CTCs can travel alone or in groups called CTC clusters. Studies have shown that CTC clusters have more potential...
Source: Hormones and Cancer - April 1, 2024 Category: Cancer & Oncology Source Type: research
Heterogeneous expression of ARID1A in colorectal cancer indicates distinguish immune landscape and efficacy of immunotherapy
ConclusionHeterogeneous ARID1A expression is accompanied by a different immune landscape. CRC patients with ARID1A-clonal expression deficiency do not benefit from the treatment of immune checkpoint inhibitors (ICIs). (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 31, 2024 Category: Cancer & Oncology Source Type: research
The predictive value of NLR, PLR and MLR in the differential diagnosis of benign uterine diseases and endometrial malignant tumors
ConclusionsIn peripheral blood, NLR, PLR and MLR have certain diagnostic value in the differential diagnosis of endometrial cancer. When NLR, PLR and MLR are elevated, we should be alert to the occurrence of endometrial malignant tumors, and the combined diagnostic efficiency is high. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 31, 2024 Category: Cancer & Oncology Source Type: research
High-throughput metabolomics identifies new biomarkers for cervical cancer
ConclusionOur study identified a diagnostic model consisting of five metabolites in plasma that can effectively distinguish CC from healthy volunteers. Furthermore, we proposed that TMAO was associated with CC progression and might serve as a potential non-invasive biomarker to predict CC substage.ImpactThese findings provided evidence of the important role of metabolic molecules in the progression of cervical cancer disease, as well as their ability as potential biomarkers. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 29, 2024 Category: Cancer & Oncology Source Type: research
Repression of LSD1/KDM1A activity improves the response of liver cancer cells to the lenvatinib
ConclusionPulrodemstat synergized with Lenvatinib based on suppression of PI3K-AKT signaling and activation of apoptotic signaling. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 28, 2024 Category: Cancer & Oncology Source Type: research
Circ_0020460 drives tumorigenesis in cervical cancer through miR-485-3p sponging
AbstractDeregulation of circular RNAs (circRNAs) is widely recognized in cancer progression. Our study aims to investigate the role of circ_0020460 in the development of cervical cancer (CC) and its potential mechanism of action. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot assays were used to detect the expression levels of circ_0020460, miR-485-3p and C-X-C motif chemokine ligand 1 (CXCL1). The roles of circ_0020460 on cell proliferation, cell migration, cell invasion, cell apoptosis, and angiogenesis were investigated using cell counting kit-8 (CCK-8) and Ethynyl deoxyuridine (Edu) assay...
Source: Hormones and Cancer - March 27, 2024 Category: Cancer & Oncology Source Type: research
Nephroblastoma-specific dysregulated gene SNHG15 with prognostic significance: scRNA-Seq with bulk RNA-Seq data and experimental validation
AbstractWilms tumor (WT) is the most common malignancy of the genitourinary system in children. Currently, the Integration of single-cell RNA sequencing (scRNA-Seq) and Bulk RNA sequencing (RNA-Seq) analysis of heterogeneity between different cell types in pediatric WT tissues could more accurately find prognostic markers, but this is lacking. RNA-Seq and clinical data related to WT were downloaded from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database. Small nucleolar RNA host gene 15 (SNHG15) was identified as a risk signature from the TARGET dataset by using weighted gene co-expr...
Source: Hormones and Cancer - March 25, 2024 Category: Cancer & Oncology Source Type: research
Effect of Annexin A2 on prognosis and sensitivity to immune checkpoint plus tyrosine kinase inhibition in metastatic renal cell carcinoma
ConclusionsUpregulated ANXA2 was associated with poor PFS and therapeutic resistance in RCC treated by IO + TKI therapy, and related with T cell exhaustion. The integrated RF score could stratify patients who would benefit from IO + TKI therapy. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 22, 2024 Category: Cancer & Oncology Source Type: research
A prognostic model for overall survival in recurrent glioma patients treated with bevacizumab-containing therapy
In this study, we sought to identify clinical and molecular factors to predict overall survival in recurrent glioma patients receiving bevacizumab-containing regimens. A cohort of 102 patients was retrospectively collected from June 2011 to January 2022 at our institution. A nomogram was generated by Cox regression and feature selection algorithms based on 19 clinicopathological and 60 molecular variables. The model's performance was internally evaluated by bootstrapping in terms of discrimination and calibration. The median overall survival from the initiation of bevacizumab administration to death or last follow-up was 1...
Source: Hormones and Cancer - March 22, 2024 Category: Cancer & Oncology Source Type: research
Circular RNA circCHSY1 silencing inhibits the malignant progression of esophageal squamous cell carcinoma
ConclusionCircCHSY1 contributed to ESCC cell malignancy, and the underlying mechanism involved the circCHSY1/miR-1229-3p/TCTN1 axis, providing potential therapeutic targets for ESCC. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 21, 2024 Category: Cancer & Oncology Source Type: research
Genetically driven predisposition leads to an unusually genomic unstable renal cell carcinoma
AbstractRenal cell carcinoma originates from the lining of the proximal convoluted renal tubule and represents the most common type of kidney cancer. Risk factors and comorbidities might be associated to renal cell carcinoma, while a small fraction of 2 –3% emerges from patients with predisposing cancer syndromes, typically associated to hereditary mutations inVHL, folliculin, fumarate hydratase orMET genes. Here, we report a case of renal cell carcinoma in patient with concurrent germline mutations inBRCA1 andRAD51 genes. This case displays an unusual high mutational burden and chromosomal aberrations compared to the ty...
Source: Hormones and Cancer - March 21, 2024 Category: Cancer & Oncology Source Type: research
FAM83D acts as an oncogene by regulating cell cycle progression via multiple pathways in synovial sarcoma: a potential novel downstream target oncogene of anlotinib
ConclusionsThis experimental study identified FAM83D as a critical regulator that contributes to the proliferation and progression of SS, suggesting that FAM83D-regulated signaling pathway may serve as a prospective target in SS management. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 21, 2024 Category: Cancer & Oncology Source Type: research
Effect of early peri-operative arterial lactate concentration level ratios on post-hepatectomy liver failure
ConclusionsEarly assessment of peri-operative arterial lactate concentration level ratios may provide experience in early intervention of complications in patients with hepatocellular carcinoma, which can reduce the likelihood of PHLF occurrence and improve patient prognosis. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 21, 2024 Category: Cancer & Oncology Source Type: research
Mechanism of regulation of KIF23 on endometrial cancer cell growth and apoptosis
ConclusionOur study provides evidence to support the inhibition of endometrial cancer by KIF23 knockdown. This offers valuable insights for future research on potential therapeutic strategies for this type of cancer.Graphical Abstract (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 21, 2024 Category: Cancer & Oncology Source Type: research
Notch appearance as a novel radiological predictor of transient expansion and good outcome of expanding schwannoma after radiotherapy
ConclusionsNew notch appearance on the outline could indicate favorable long-term outcomes of expanding schwannomas post-treatment. Clinical relevance statementNotch appearance can help differentiate a transient schwannoma from a real tumor expansion, and it is a novel predictor of better outcomes of expanding schwannomas after radiotherapy.Graphical Abstract (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 19, 2024 Category: Cancer & Oncology Source Type: research
