Late effects of high-dose methotrexate in childhood cancer survivors: a Swiss single centre observational study
ConclusionLate effects in CCS treated with HD-MTX are frequent. Our findings could add to the COG guidelines, where only screening for the musculoskeletal, neuropsychological, and hepatobiliary systems are recommended. More patient data need to be collected and analysed using the suggested standardised approach, to increase the quality of evidence for future screening recommendations. (Source: Hormones and Cancer)
Source: Hormones and Cancer - January 25, 2024 Category: Cancer & Oncology Source Type: research
Correction: Treatment outcomes of radiotherapy with concurrent weekly cisplatin in older patients with locally advanced head and neck squamous cell carcinoma
(Source: Hormones and Cancer)
Source: Hormones and Cancer - January 25, 2024 Category: Cancer & Oncology Source Type: research
Mitochondrial-mediated apoptosis as a therapeutic target for FNC (2 ′-deoxy-2′-b-fluoro-4′-azidocytidine)-induced inhibition of Dalton’s lymphoma growth and proliferation
ConclusionFNC represents an efficient and targeted treatment strategy against T-cell lymphoma. FNC ’s proficient ability to induce apoptosis through ROS generation and MMP reduction makes it a promising candidate for developing newer and more effective anticancer therapies. Continued research could unveil FNC’s potential role in designing a better therapeutic approach against NHL. (Source: Hormones and Cancer)
Source: Hormones and Cancer - January 22, 2024 Category: Cancer & Oncology Source Type: research
Correlation of DNA methylation of DNMT3A and TET2 with oral squamous cell carcinoma
AbstractOral squamous cell carcinoma (OSCC) is the sixth most common malignancy worldwide. Abnormal epigenetic modifications, including DNA methylation, are hallmarks of cancer and implicated in the development of various tumors. DNA methylation is catalyzed by the DNA methyltransferase and ten-eleven translocation dioxygenase families, withDNMT3A andTET2 being the most widely studied members, respectively. The correlation of methylation β values and clinical features was conducted in patients with OSCC in The Cancer Genome Atlas database. DNA methylation and protein expression levels ofDNMT3A andTET2 in tissues were anal...
Source: Hormones and Cancer - January 22, 2024 Category: Cancer & Oncology Source Type: research
CircUCK2 promotes hepatocellular carcinoma development by upregulating UCK2 in a mir-149-5p-dependent manner
ConclusionCircUCK2 contributed to HCC malignant progression in vitro and in vivo via targeting miR-149-5p/UCK2 axis, demonstrating that circUCK2 might be a novel therapeutic target for HCC. (Source: Hormones and Cancer)
Source: Hormones and Cancer - January 20, 2024 Category: Cancer & Oncology Source Type: research
The role of stromal cells in epithelial –mesenchymal plasticity and its therapeutic potential
AbstractThe epithelial –mesenchymal transition (EMT) is a critical tumor invasion and metastasis process. EMT enables tumor cells to migrate, detach from their original location, enter the circulation, circulate within it, and eventually exit from blood arteries to colonize in foreign sites, leading to the development o f overt metastases, ultimately resulting in death. EMT is intimately tied to stromal cells around the tumor and is controlled by a range of cytokines secreted by stromal cells. This review summarizes recent research on stromal cell-mediated EMT in tumor invasion and metastasis. We also discuss the e ffect...
Source: Hormones and Cancer - January 20, 2024 Category: Cancer & Oncology Source Type: research
Breast cancer cells and adipocytes in hypoxia: metabolism regulation
In this study, we described the mechanism linking the hypoxia-sensing pathway manifested by HIF to adipocytes and breast cancer and discussed the mechanism underlying the role of hypoxic adipocytes in breast cancer development from the perspective of metabolic remodeling. The processes and pathways in hypoxic adipocytes could be a promising target in breast cancer therapy. (Source: Hormones and Cancer)
Source: Hormones and Cancer - January 18, 2024 Category: Cancer & Oncology Source Type: research
Anti-prostate cancer mechanism of black ginseng during the & quot;nine steaming and nine sun-drying & quot; process based on HPLC analysis combined with vector space network pharmacology
AbstractHPLC analysis determined six small-molecule organic acids, maltol, 5-hydroxymethylfurfural (5-HMF), 17 ginsenosides, four oligosaccharides, and 20 amino acids in black ginseng samples with different processing times. Based on the content determination results, the differential ingredients in the processing of black ginseng were screened by multivariate statistical analysis. Network pharmacological methods obtained the core targets and pathways of the above ingredients against prostate cancer. Finally, the entropy weight method was used to assign values to the above ingredients, targets, and pathways, and the vector...
Source: Hormones and Cancer - January 18, 2024 Category: Cancer & Oncology Source Type: research
Genomic and transcriptomic profiling of hepatocellular carcinoma reveals a rare molecular subtype
AbstractHepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide, occurring predominantly in patients with underlying chronic liver disease and cirrhosis. Here, we describe a case of a 62-year-old man that was admitted to our hospital and diagnosed with HCC where the cancer has already metastasized to the retroperitoneum and peritoneum. In order to better characterize the HCC, both the cancerous liver tissue and the adjacent normal liver tissue of the patient were collected and subjected to a genomic, transcriptomic and proteomic analysis. Our patient carries a highly mutated HCC, which i...
Source: Hormones and Cancer - January 16, 2024 Category: Cancer & Oncology Source Type: research
Low expression of PRRG2 in kidney renal clear cell carcinoma: an immune infiltration-associated prognostic biomarker
ConclusionPRRG2 may potentially impact prognosis in KIRC patients by regulating immune infiltration, thus rendering PRRG2 a promising candidate prognostic biomarker for KIRC-associated immune infiltration. (Source: Hormones and Cancer)
Source: Hormones and Cancer - January 16, 2024 Category: Cancer & Oncology Source Type: research
GLUD1 inhibits hepatocellular carcinoma progression via ROS-mediated p38/JNK MAPK pathway activation and mitochondrial apoptosis
AbstractGlutamate dehydrogenase 1 (GLUD1) is an important enzyme in glutamine metabolism. Previously, we found GLUD1 was down-regulated in tumor tissues of hepatocellular carcinoma (HCC) patients by proteomics study. To explore its role in the progression of HCC, the expressional level of GLUD1 was firstly examined and presented as that both the protein and mRNA levels were down-regulated in tumor tissues compared to the normal liver tissues. GLUD1 overexpression significantly inhibited HCC cells proliferation, migration, invasion and tumor growth both in vitro and in vivo, while GLUD1 knocking-down promoted HCC progressio...
Source: Hormones and Cancer - January 12, 2024 Category: Cancer & Oncology Source Type: research
A novel cholesterol metabolism-related ferroptosis pathway in hepatocellular carcinoma
ConclusionsOur findings shed new light on the association between cholesterol metabolism and ferroptosis in HCC, and suggest that IL1B is the necessary node for cholesterol to lead to ferroptosis process in HCC. Also, we identified the potential role of indomethacin in adjuvant therapy of HCC with complications of abnormal cholesterol metabolism. (Source: Hormones and Cancer)
Source: Hormones and Cancer - January 8, 2024 Category: Cancer & Oncology Source Type: research
P129, a pyrazole ring-containing isolongifolanone-derivate: synthesis and investigation of anti-glioma action mechanism
ConclusionThe pyrazole ring-containing isolongifolanone derivateP129 exhibited promising anti-glioma activity by targeting CDK-2 and promoting apoptosis, indicating its potential importance as a new chemotherapeutic option for glioma. (Source: Hormones and Cancer)
Source: Hormones and Cancer - January 6, 2024 Category: Cancer & Oncology Source Type: research
Vitality, viability, long-term clonogenic survival, cytotoxicity, cytostasis and lethality: what do they mean when testing new investigational oncology drugs?
AbstractIn the field of experimental therapeutics for oncology purposes researchers are continuously evaluating the toxicity of novel treatment approaches against cancer cells. Within this topic of research, it is highly critical to define parameters of toxicity that denote when cancer cells are perturbed in their functionality by a new investigational drug. As the goal for these approaches is to achieve cellular demise, then what approaches to use and what do they mean in terms of assessing such cell death is of critical importance. In this comment article we highlight the definition of vitality and differentiate it from ...
Source: Hormones and Cancer - January 5, 2024 Category: Cancer & Oncology Source Type: research
The relationship between physical activity, self-efficacy and quality of life in colorectal cancer survivors: a multicenter cross-sectional study
ConclusionsColorectal cancer survivors exhibited low levels of physical activity, self-efficacy, and quality of life. Their health is influenced by self-efficacy, recreational physical activity, and chemoradiotherapy. When developing intervention plans for colorectal cancer survivorship, it is crucial to consider survivors' self-efficacy and the type of physical activity in which they engage. (Source: Hormones and Cancer)
Source: Hormones and Cancer - January 5, 2024 Category: Cancer & Oncology Source Type: research
