A novel cholesterol metabolism-related ferroptosis pathway in hepatocellular carcinoma

ConclusionsOur findings shed new light on the association between cholesterol metabolism and ferroptosis in HCC, and suggest that IL1B is the necessary node for cholesterol to lead to ferroptosis process in HCC. Also, we identified the potential role of indomethacin in adjuvant therapy of HCC with complications of abnormal cholesterol metabolism.
Source: Hormones and Cancer - Category: Cancer & Oncology Source Type: research