Role of exosome-mediated molecules SNORD91A and SLC40A1 in M2 macrophage polarization and prognosis of ESCC
ConclusionsOur study identified exosome-associated molecules, namely SNORD91A and SLC40A1, which notably impact ESCC prognosis and local M2 macrophage recruitment, thereby presenting potential therapeutic targets for ESCC. (Source: Hormones and Cancer)
Source: Hormones and Cancer - September 23, 2023 Category: Cancer & Oncology Source Type: research
Impact of primary resistance to front-line targeted therapy in metastatic renal cell carcinoma on subsequent immune-checkpoint-inhibition
ConclusionPrimary TKI resistance of aRCC was neither significantly associated with responsiveness to ICI during sequential therapy nor with PFS and OS. This adds the evidence for ICI based sequential therapy in primary TKI resistant aRCC. (Source: Hormones and Cancer)
Source: Hormones and Cancer - September 23, 2023 Category: Cancer & Oncology Source Type: research
TRIP13 overexpression in hepatocellular carcinoma: implications for poor prognosis and immune cell infiltration
ConclusionThese findings suggest that TRIP13 could be a potential prognostic biomarker for HCC. (Source: Hormones and Cancer)
Source: Hormones and Cancer - September 22, 2023 Category: Cancer & Oncology Source Type: research
M6A-mediated upregulation of HOXC10 promotes human hepatocellular carcinoma development through PTEN/AKT/mTOR signaling pathway
AbstractHuman Hox genes (Homeobox) play a crucial role in embryonic development and cancer. The HOXC10 gene, a member of the HOX family, has been reported abnormally expressed in several cancers. However, the association between HOXC10 and hepatocellular carcinoma (HCC) remains to be elucidated. In the present study, tissue microarray cohort data showed that high levels of HOXC10 expression predicted a poor survival in HCC patients. Meanwhile, HOXC10 was significantly upregulated in the Huh7 cell line compared with the well differentiated cell line HepG2 and human normal liver cells. Functionally, silencing HOXC10 in Huh7 ...
Source: Hormones and Cancer - September 21, 2023 Category: Cancer & Oncology Source Type: research
Comparative analysis of single-cell transcriptome reveals heterogeneity in the tumor microenvironment of lung adenocarcinoma and brain metastases
ConclusionsThis study depicts a single-cell atlas of lung adenocarcinoma and brain metastases by scRNA-seq and paves the way for the development of future therapeutic targets for brain metastases from lung cancer. (Source: Hormones and Cancer)
Source: Hormones and Cancer - September 15, 2023 Category: Cancer & Oncology Source Type: research
Identification of galactosamine-(N-acetyl)-6-sulfatase (GALNS) as a novel therapeutic target in progression of nasopharyngeal carcinoma
In this study, we found that GALNS is overexpressed in NPC cell lines and tissues compared to the normal nasopharyngeal counterparts. Knocking down GALNS expression in the NPC cells significantly decreased their proliferation in vitro, and inhibited xenograft growth in a mouse model. Mechanistically, the anti-proliferative effect of GALNS silencing was the result of autophagy induction via the inhibition of PI3K –AKT–mTOR signaling pathway. Taken together, GALNS drives the progression of NPC via PI3K–AKT–mTOR signaling-mediated autophagy, and is therefore a promising therapeutic target. (Source: Hormones and Cancer)
Source: Hormones and Cancer - September 14, 2023 Category: Cancer & Oncology Source Type: research
miR-17 ~ 92 suppresses proliferation and invasion of cervical cancer cells by inhibiting cell cycle regulator Cdt2
In this study, we report that miR-17 ~ 92 directly recruits to 3’UTR of Cdt2 and downregulates this oncogene which suppresses the proliferation, migration and invasion capabilities of the CC cell lines without affecting non-cancerous cells. We further show that suppression o f Cdt2 by miR-17 ~ 92, blocks the cancerous cells in S phase and induces apoptosis, eventually leading to their death. Hence, our work for the first time, mechanistically shows how miR-17 ~ 92 could work as tumor suppressor in cervical cancer cells, opening up the potential of miR-17 ~ 9 2 to be used in developing therapy for cervical...
Source: Hormones and Cancer - September 14, 2023 Category: Cancer & Oncology Source Type: research
Development of a thyroid cancer prognostic model based on the mitophagy-associated differentially expressed genes
ConclusionThe nomogram risk prediction model was developed to precisely predict the survival rate of ThyC patients. The model was validated based on the most significant DEG GGCT gene expression in ThyC. This model may serve as a guide for the creation of precise treatment plans for ThyC patients. (Source: Hormones and Cancer)
Source: Hormones and Cancer - September 14, 2023 Category: Cancer & Oncology Source Type: research
The potential immuno-stimulating effect of curcumin, piperine, and taurine combination in hepatocellular carcinoma; a pilot study
ConclusionCPT could exhibit a potential immune-stimulating effect in HCC patients. The current trial had been registered at the National Hepatology and Tropical Medicine Research Institute (NHTMRI), with a registration number of NHTMRI-IRB 2-21 on 5th January 2021. (Source: Hormones and Cancer)
Source: Hormones and Cancer - September 13, 2023 Category: Cancer & Oncology Source Type: research
Investigating the potential mechanism of quercetin against cervical cancer
ConclusionsIn summation, our study suggests that quercetin holds promise as a potential therapeutic agent for mitigating coronavirus function, specifically through its interaction with the primary protease. This research offers novel insights into exploring COVID-19 susceptibility and enhancing survival in cervical cancer patients. (Source: Hormones and Cancer)
Source: Hormones and Cancer - September 13, 2023 Category: Cancer & Oncology Source Type: research
Integrating TCGA and single-cell sequencing data for colorectal cancer: a 10-gene prognostic risk assessment model
This study sought to address this gap by using the Seurat package to analyze a single-cell sequencing dataset (GSE178318) of colorectal cancer, thereby identifying distinctive marker genes characterizing various cell subpopulations. Through CIBERSORT analysis of colorectal cancer data within The Cancer Genome Atlas (TCGA) database, significant differences existed in both cell subpopulations and prognostic values. Employing WGCNA, we pinpointed modules exhibiting strong correlations with these subpopulations, subsequently utilizing the survival package coxph to isolate genes within these modules. Further stratification of T...
Source: Hormones and Cancer - September 13, 2023 Category: Cancer & Oncology Source Type: research
Correction: MUC13 promotes the development of esophageal cancer by upregulating the expression of o-glycan process-related molecules
(Source: Hormones and Cancer)
Source: Hormones and Cancer - September 11, 2023 Category: Cancer & Oncology Source Type: research
MiR-3529-3p from PDGF-BB-induced cancer-associated fibroblast-derived exosomes promotes the malignancy of oral squamous cell carcinoma
This study aims to explore the role of exosomes from cancer-associated fibroblasts (CAFs) induced by PDGF-BB in promoting the malignancy of oral squamous cell carcinoma (OSCC) and provide new insight into the mechanism of OSCC progression and its treatment.Main methodsExosomes were extracted from human oral mucosa fibroblasts (hOMFs) and CAFs. Differentially expressed miRNAs of exosomes between hOMFs and CAFs were analysed using high-throughput sequencing and self-programmed R software. Cal-27, a human tongue squamous carcinoma cell line, was treated with exosomes. Differentially expressed miRNAs between clinical cancer ti...
Source: Hormones and Cancer - September 5, 2023 Category: Cancer & Oncology Source Type: research
Immune checkpoint inhibitors combined with or without radio(chemo)therapy for locally advanced or recurrent/metastatic esophageal squamous cell carcinoma
ConclusionsICIs combined with radiotherapy/chemotherapy are safe and effective in LA/RM ESCC patients. Intervention of radiotherapy, the number of immunotherapy cycles and occurrence of dysphagia affecting the overall survival of LR/RM ESCC patients. Intervention of radiotherapy was an independent prognosis factor for OS and PFS and associated with better treatment response. (Source: Hormones and Cancer)
Source: Hormones and Cancer - September 4, 2023 Category: Cancer & Oncology Source Type: research
Natural killer cells modified with a Gpc3 aptamer enhance adoptive immunotherapy for hepatocellular carcinoma
ConclusionsThe proposed strategy endows NK cells with a tumor-specific targeting ability to enhance adoptive therapeutic efficiency in GPC3+ hepatocellular carcinoma. (Source: Hormones and Cancer)
Source: Hormones and Cancer - September 4, 2023 Category: Cancer & Oncology Source Type: research
