A comprehensive prognostic score for head and neck squamous cancer driver genes and phenotype traits
ConclusionThe APMHO score combining transcriptional and clinical variables showed good prognostic ability for HNSCC overall survival outcomes and was associated with different patterns of phenotypical features, immune and mutational landscape, and immunotherapy sensitivity marker expression. Future studies should validate this score in independent clinical cohorts. (Source: Hormones and Cancer)
Source: Hormones and Cancer - October 28, 2023 Category: Cancer & Oncology Source Type: research
Necroptosis-related genes are associated with prognostic features of kidney renal clear cell carcinoma
ConclusionsMYCN and CDKN2A are potential targets and valuable prognostic biomarkers for combining immunotherapy with necroptosis in kidney renal clear cell carcinoma. CDKN2A promotes the migration of renal cancer cells, while MYCN inhibits their migration. (Source: Hormones and Cancer)
Source: Hormones and Cancer - October 25, 2023 Category: Cancer & Oncology Source Type: research
Evaluation of the relationship between Ki67 expression level and neoadjuvant treatment response and prognosis in breast cancer based on the Neo-Bioscore staging system
ConclusionNeo-Bioscore staging system is found to be important in predicting survival. The posttreatment Ki67 level is more important than pretreatment Ki67 level in predicting survival. (Source: Hormones and Cancer)
Source: Hormones and Cancer - October 24, 2023 Category: Cancer & Oncology Source Type: research
Integrated analysis of single-cell and bulk RNA-sequencing reveals the poor prognostic value of ABCA1 in gastric adenocarcinoma
ConclusionHigh ABCA1 expression promotes an adverse immune microenvironment and low survival rates in patients with GAC. Furthermore, ABCA1 and ABCA1-producing macrophages may serve as novel molecular targets in GAC treatment. (Source: Hormones and Cancer)
Source: Hormones and Cancer - October 24, 2023 Category: Cancer & Oncology Source Type: research
A risk score model based on lipid metabolism-related genes could predict response to immunotherapy and prognosis of lung adenocarcinoma: a multi-dataset study and cytological validation
ConclusionOur study highlights the crucial roles of lipid metabolism in LUAD and provides a reliable risk score model, which can aid in predicting prognosis and response to immunotherapy. Furthermore, we investigated the roles of PTDSS1 in LUAD carcinogenesis, which showed that PTDSS1 regulated proliferation and apoptosis of LUAD cells. (Source: Hormones and Cancer)
Source: Hormones and Cancer - October 24, 2023 Category: Cancer & Oncology Source Type: research
ZDHHC9: a promising therapeutic target for triple-negative breast cancer through immune modulation and immune checkpoint blockade resistance
ConclusionThese findings suggest that ZDHHC9 is a valuable marker for guiding the classification, diagnosis and prognosis of TNBC and developing specific targeted therapies. (Source: Hormones and Cancer)
Source: Hormones and Cancer - October 24, 2023 Category: Cancer & Oncology Source Type: research
PIK3CD correlates with prognosis, epithelial –mesenchymal transition and tumor immune infiltration in breast carcinoma
ConclusionsOur findings reveal that PIK3CD expression is associated with prognosis, EMT, and tumor immune infiltration in BRCA patients. (Source: Hormones and Cancer)
Source: Hormones and Cancer - October 20, 2023 Category: Cancer & Oncology Source Type: research
Machine learning-based predictive model for the differential diagnosis of ≤ 5 cm gastric stromal tumor and gastric schwannoma based on CT images
This study explored the value of computed tomography (CT) combined with machine learning (ML) algorithms to find the best model to discriminate them. A total of 126 patients with GST ≤ 5 cm and 35 patients with GS ≤ 5 during 2013–2022 were included. CT imaging features included qualitative data (tumor location, growth pattern, lobulation, surface ulcer status, necrosis, calcification, and surrounding lymph nodes) and quantitative data [long diameter (LD); short diameter (SD); LD/SD ratio; degree of enhancement (DE); heterogeneous degree (HD)]. Patients were randomly divided into a training set (n = 112) ...
Source: Hormones and Cancer - October 19, 2023 Category: Cancer & Oncology Source Type: research
Regulation of T cells by myeloid-derived suppressor cells: emerging immunosuppressor in lung cancer
AbstractMyeloid-derived suppressor cells (MDSCs), major components maintaining the immune suppressive microenvironment in lung cancer, are relevant to the invasion, metastasis, and poor prognosis of lung cancer, through the regulation of epithelial-mesenchymal transition, remodeling of the immune microenvironment, and regulation of angiogenesis. MDSCs regulate T-cell immune functions by maintaining a strong immunosuppressive microenvironment and promoting tumor invasion. This raises the question of whether reversing the immunosuppressive effect of MDSCs on T cells can improve lung cancer treatment. To understand this furth...
Source: Hormones and Cancer - October 19, 2023 Category: Cancer & Oncology Source Type: research
Prediction model of no-response before the first transarterial chemoembolization for hepatocellular carcinoma: TACF score
AbstractPrevious clinic models for patients with hepatocellular carcinoma (HCC) receiving transarterial chemoembolization (TACE) mainly focused on the overall survival, whereas a simple-to-use tool for predicting the response to the first TACE and the management of risk classification before TACE are lacking. Our aim was to develop a scoring system calculated manually for these patients. A total of 437 patients with hepatocellular carcinoma (HCC) who underwent TACE treatment were carefully selected for analysis. They were then randomly divided into two groups: a training group comprising 350 patients and a validation group...
Source: Hormones and Cancer - October 17, 2023 Category: Cancer & Oncology Source Type: research
Clinical advances in oncolytic virus therapy for malignant glioma: a systematic review
ConclusionsCurrent clinical trials have initially shown the potential of oncolytic virotherapy as a new treatment for malignant glioma. Besides development of virus types, the strategy of OV use is an urgent problem to be solved in future clinical application, such as repeated administrations, innovative drug delivery systems, and biomarkers. (Source: Hormones and Cancer)
Source: Hormones and Cancer - October 16, 2023 Category: Cancer & Oncology Source Type: research
Exploring oncogenes for renal clear cell carcinoma based on G protein-coupled receptor-associated genes
AbstractG protein-coupled receptors (GPCRs) are a class of receptors on cell membranes that regulate various biological processes in cells, such as cell proliferation, differentiation, migration, apoptosis, and metabolism, by interacting with G proteins. However, the role of G protein-coupled receptors in predicting the prognosis of renal clear cell carcinoma is still unknown. The transcriptome data and clinical profiles of renal clear cell carcinoma patients, were downloaded from TCGA databases, and the validation group data were downloaded from number GSE167573, including 63 tumor samples and 14 normal samples. Single-ce...
Source: Hormones and Cancer - October 10, 2023 Category: Cancer & Oncology Source Type: research
Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score
ConclusionsThe LC score is an accurate and non-invasive option for early LC diagnosis and a valuable complement to LC screening procedures based on computed tomography. (Source: Hormones and Cancer)
Source: Hormones and Cancer - October 3, 2023 Category: Cancer & Oncology Source Type: research
Updating approach for lexicographic optimization-based planning to improve cervical cancer plan quality
ConclusionsThis study showed the flexibility of the Lexicographic approach in creating more demanding Wish Lists able to potentially minimize toxicities in RT plans. (Source: Hormones and Cancer)
Source: Hormones and Cancer - September 30, 2023 Category: Cancer & Oncology Source Type: research
Synergist for antitumor therapy: Astragalus polysaccharides acting on immune microenvironment
AbstractVarious new treatments are emerging constantly in anti-tumor therapies, including chemotherapy, immunotherapy, and targeted therapy. However, the efficacy is still not satisfactory. Astragalus polysaccharide is an important bioactive component derived from the dry root ofRadix astragali. Studies found that astragalus polysaccharides have gained great significance in increasing the sensitivity of anti-tumor treatment, reducing the side effects of anti-tumor treatment, reversing the drug resistance of anti-tumor drugs, etc. In this review, we focused on the role of astragalus polysaccharides in tumor immune microenvi...
Source: Hormones and Cancer - September 24, 2023 Category: Cancer & Oncology Source Type: research
