Pan-cancer analyses of senescence-related genes in extracellular matrix characterization in cancer
ConclusionsWe conducted a comprehensive evaluation of the genomes and immunogenomics of ECM-SRGs, along with their clinical features in 33 solid tumors. This may provide insights into the relationship between ECM-SRGs and tumorigenesis. Consequently, targeting these ECM-SRGs holds promise as a clinical approach for cancer treatment. (Source: Hormones and Cancer)
Source: Hormones and Cancer - November 20, 2023 Category: Cancer & Oncology Source Type: research
A comprehensive analysis of SLC25A1 expression and its oncogenic role in pan-cancer
ConclusionsOur findings suggest the potential of SLC25A1 as a prognostic biomarker for cancers and a therapeutic target for precise antitumor strategy and cancer immunotherapy. (Source: Hormones and Cancer)
Source: Hormones and Cancer - November 19, 2023 Category: Cancer & Oncology Source Type: research
Novel diagnostic biomarkers of oxidative stress, immune- infiltration characteristics and experimental validation of SERPINE1 in colon cancer
ConclusionIn conclusion, this study introduces a new approach for the early diagnosis and treatment of CC, and further exploration of SERPINE1 could potentially lead to a significant advancement. (Source: Hormones and Cancer)
Source: Hormones and Cancer - November 18, 2023 Category: Cancer & Oncology Source Type: research
Geriatric nutritional risk index as a prognostic marker of first-line immune checkpoint inhibitor combination therapy in patients with renal cell carcinoma: a retrospective multi-center study
ConclusionThe prognostic efficiency of GNRI was inferior to that of the KPS score at the initiation of the first-line ICI combination therapy for clear cell RCC. (Source: Hormones and Cancer)
Source: Hormones and Cancer - November 16, 2023 Category: Cancer & Oncology Source Type: research
Exosomal miR-200c and miR-141 as cerebrospinal fluid biopsy biomarkers for the response to chemotherapy in primary central nervous system lymphoma
ConclusionCollectively, miR-200c and miR-141 are likely to be upregulated in CSF exosomes after chemotherapy in patients with PCNSL, highlighting their potential as reliable liquid biopsy biomarkers for PCNSL diagnosis and chemotherapy efficacy monitoring. (Source: Hormones and Cancer)
Source: Hormones and Cancer - November 16, 2023 Category: Cancer & Oncology Source Type: research
A gene signature predicting prognosis of patients with lower-grade gliomas receiving temozolomide therapy
In this study, we aim to investigate the relationship between gene expressions and the prognosis of TMZ therapy in LGGs. We integrated transcriptome and clinical data of 171 LGGs from the Chinese Glioma Genome Atlas (CGGA). Consensus LASSO Cox regression was used to identify 14 key genes related to different clinical outcomes under TMZ chemotherapy. We constructed and evaluated a risk score based on the 14 genes. Patients with LGGs of lower risk scores (low-risk group) generally had better survival than those LGGs of higher risk scores (high-risk group), which is independent of clinicopathological factors. High-risk patien...
Source: Hormones and Cancer - November 13, 2023 Category: Cancer & Oncology Source Type: research
Prognostic clinical phenotypes associated with tumor stemness in the immune microenvironment of T-cell exhaustion for hepatocellular carcinoma
In conclusion, we identified two clinic al subtypes with different prognoses, TEX infiltration abundance, tumor cell stemness index, and immunotherapy response based on TEXSRGs, and developed and validated a TEXSRGs-score capable of accurately predicting survival outcomes in HCC patients by comprehensive bioinformatics analysis. We believ e that the TEXSRGs-score has prospective clinical relevance for prognostic assessment and may help physicians select prospective responders in preference to current immune checkpoint inhibitors (ICIs). (Source: Hormones and Cancer)
Source: Hormones and Cancer - November 13, 2023 Category: Cancer & Oncology Source Type: research
Identification of m6A-associated genes as prognostic and immune-associated biomarkers in Wilms tumor
ConclusionsTaken together, our study first time screened the m6A-related genes and revealed that ADGRG2, CPD, CTHRC1, and LRTM2 are the prognostic and immune-associated biomarkers in WT. (Source: Hormones and Cancer)
Source: Hormones and Cancer - November 8, 2023 Category: Cancer & Oncology Source Type: research
Prediction and therapeutic targeting of the tumor microenvironment-associated gene CTSK in gastric cancer
ConclusionCTSK was validated as a potential prognostic biomarker related to TME of GC and could be a promising next-generation immunotherapeutic target for GC. (Source: Hormones and Cancer)
Source: Hormones and Cancer - November 6, 2023 Category: Cancer & Oncology Source Type: research
The genes regulating sensitivity of tumor cells to T cell-mediated killing: could they be potential personalized immunotherapeutic targets in head and neck squamous cell carcinoma?
ConclusionThe 9 identified hub DE-STTK genes (MYF6, AATF, AURKA, CXCL9, DPM2, MYO1B, NCBP2, TNFRSF12A, and TRAF1) are presumptively implicated in the modulation of tumor immunity in HNSC. These genes, along with their enriched pathways, hold promise as potential personalized immunotherapeutic targets for the treatment of HNSC, thereby offering novel avenues for therapeutic intervention in this malignancy. (Source: Hormones and Cancer)
Source: Hormones and Cancer - November 5, 2023 Category: Cancer & Oncology Source Type: research
Association between testosterone and cancers risk in women: a two-sample Mendelian randomization study
ConclusionsThis study elucidates the role of testosterone on the development of breast cancer, endometrial cancer, ovarian cancer, and cervical cancer. It also hints at a potential but fragile link between testosterone and bladder cancer, as well as thyroid cancer. Nonetheless, it's worth noting that no statistically significant relationship between testosterone and various other types of cancer in females was identified. (Source: Hormones and Cancer)
Source: Hormones and Cancer - November 4, 2023 Category: Cancer & Oncology Source Type: research
Nomogram development and external validation for predicting overall survival and cancer-specific survival in patients with primary retroperitoneal sarcoma: a retrospective cohort study
The objective of this study was to construct prognostic nomograms for predicting OS and CSS in RPS patients.MethodsWe identified a total of 1166 RPS patients from the Surveillance, Epidemiology and End Results (SEER) database, and an additional 261 cases were collected from a tertiary cancer center. The study incorporated various clinicopathological and epidemiologic features as variables, and prediction windows for overall survival (OS) and cancer-specific survival (CSS) were set at 3, 5, and 7 years. Multivariable Cox models were utilized to develop the nomograms, and variable selection was performed using a backward pro...
Source: Hormones and Cancer - November 1, 2023 Category: Cancer & Oncology Source Type: research
Molecular pathogenesis, mechanism and therapy of Cav1 in prostate cancer
This article reviews the structure, physiological and pathological functions of Cav1, the pathogenic signaling pathways involved in prostate cancer, and the current drug treatment of prostate cancer. C av1 mainly affects the occurrence of prostate cancer through AKT/mTOR, H-RAS/PLCε, CD147/MMPs and other pathways, as well as substance metabolism including lipid metabolism and aerobic glycolysis. Baicalein, simvastatin, triptolide and other drugs can effectively inhibit the growth of prostate canc er. As a biomarker of prostate cancer, Cav1 may provide a potential therapeutic target for the treatment of prostate cancer. (S...
Source: Hormones and Cancer - November 1, 2023 Category: Cancer & Oncology Source Type: research
Down-regulation of DPP4 by TGF β1/miR29a-3p inhibited proliferation and promoted migration of ovarian cancer cells
ConclusionDPP4 was downregulated in OV patients. DPP4 knockdown significantly inhibited OVCAR-3 and SKOV-3 cell proliferation and promoted cell migration. DDP4 can be downregulated by TGF β1 through the upregulation of miR-29a-3p in OV cells. (Source: Hormones and Cancer)
Source: Hormones and Cancer - October 31, 2023 Category: Cancer & Oncology Source Type: research
Posttraumatic growth and illness perception in survivors of adolescent and young adult cancer
ConclusionsFinding ways to promote PTG and to identify and address maladaptive illness perceptions may help survivors transform their experience into something meaningful for their future life. (Source: Hormones and Cancer)
Source: Hormones and Cancer - October 30, 2023 Category: Cancer & Oncology Source Type: research
