Re-immunotherapy with nivolumab plus ipilimumab in advanced non-small cell lung cancer patients previously treated with anti-programmed death-1 and/or anti-programmed death ligand-1 antibodies
ConclusionRe-immunotherapy with nivolumab plus ipilimumab after anti-PD-1 and/or anti-PD-L1 immunotherapy may be feasible and provide clinical benefit in selected patients. Further prospective studies are warranted to identify the patient population that may benefit from re-immunotherapy. (Source: Hormones and Cancer)
Source: Hormones and Cancer - August 31, 2023 Category: Cancer & Oncology Source Type: research
Effects of metalloprotease ADAMTS12 on cervical cancer cell phenotype and its potential mechanism
AbstractADAMTS12 is a gene widely expressed in human tissues. We studied the expression level of ADAMTS12 in cervical cancer tissue and its relationship with clinicopathological features. We also explored the function of ADAMTS12 in cervical cancer cells and its underlying mechanisms. We found the higher expression level of ADAMTS12 in cancer tissues, which was associated with the worse overall survival rate. The immunofluorescence assay showed that the cytoplasm of cervical cancer cells is the main expression site of ADAMTS12. Overexpression of ADAMTS12 in HeLa and CaSki cells prominently promoted the cell proliferation, ...
Source: Hormones and Cancer - August 29, 2023 Category: Cancer & Oncology Source Type: research
Results of a pilot risk-based lung cancer screening study: outcomes and comparisons to a Medicare eligible cohort
ConclusionProspective application of risk-based screening identifies screening candidates who are similar to a traditionally eligible Medicare cohort and future research should focus on the impact of risk calculators on lung cancer outcomes and optimal usability in clinical environments.This study was retrospectively registered on clinicaltrials.gov (NCT03683940) on 09/25/2018. (Source: Hormones and Cancer)
Source: Hormones and Cancer - August 29, 2023 Category: Cancer & Oncology Source Type: research
OSR1 downregulation indicates an unfavorable prognosis and activates the NF- κB pathway in ovarian cancer
ConclusionOur findings indicate that OSR1 is downregulated and associated with OC prognosis. OSR1 suppresses NF- κB pathway activity and inhibits OC progression by targeting the NF-κB pathway. (Source: Hormones and Cancer)
Source: Hormones and Cancer - August 29, 2023 Category: Cancer & Oncology Source Type: research
Caveolin-1 promotes glioma progression and maintains its mitochondrial inhibition resistance
ConclusionTherefore, we identified a key gene CAV1 and deciphered its function in glioma progression and prognosis, proposing that CAV1 may be a therapeutic target for gliomas.Graphical Abstract (Source: Hormones and Cancer)
Source: Hormones and Cancer - August 29, 2023 Category: Cancer & Oncology Source Type: research
Chemotherapy following immune checkpoint inhibitors in recurrent or metastatic head and neck squamous cell carcinoma: clinical effectiveness and influence of inflammatory and nutritional factors
ConclusionsChemotherapy following ICI is highly effective. There were no significant differences in the chemotherapy regimens. Inflammatory and nutritional factors may associate with patient prognosis after chemotherapy. (Source: Hormones and Cancer)
Source: Hormones and Cancer - August 29, 2023 Category: Cancer & Oncology Source Type: research
LncRNA GAS5-hnRNPK axis inhibited ovarian cancer progression via inhibition of AKT signaling in ovarian cancer cells
ConclusionsOur study showed one of the mechanisms that GAS5 inhibited ovarian cancer metastasis by down-regulating hnRNPK expression, and GAS5 can be used to predict the prognosis of ovarian cancer patients.Graphical Abstract (Source: Hormones and Cancer)
Source: Hormones and Cancer - August 28, 2023 Category: Cancer & Oncology Source Type: research
Effect of microserum environment stimulation on extraction and biological function of colorectal cancer stem cells
ConclusionsMicroserum environment stimulation could be an effective strategy for reliable enrichment of intact CCSCs, and a more efficient CSC enrichment method. (Source: Hormones and Cancer)
Source: Hormones and Cancer - August 28, 2023 Category: Cancer & Oncology Source Type: research
Senescence-associated secretory phenotype constructed detrimental and beneficial subtypes and prognostic index for prostate cancer patients undergoing radical prostatectomy
ConclusionsFrom perspective of SASP, we found detrimental and beneficial tumor subtypes which were closely associated with BCR-free survival for PCa patients, which might be important for the furture research in the field of PCa. (Source: Hormones and Cancer)
Source: Hormones and Cancer - August 25, 2023 Category: Cancer & Oncology Source Type: research
A MRI-based radiomics model for predicting the response to anlotinb combined with temozolomide in recurrent malignant glioma patients
ConclusionsThe above-described radiomics model performed well, which can serve as a clinical tool for individualized prediction of the response to anlotinb combined with TMZ in rMG patients. (Source: Hormones and Cancer)
Source: Hormones and Cancer - August 23, 2023 Category: Cancer & Oncology Source Type: research
Immune changes induced by periampullary adenocarcinoma are reversed after tumor resection and modulate the postoperative survival
ConclusionOur data suggests systemic immunologic changes in adenocarcinoma patients, which are reversible six weeks after tumor resection. Additionally, the preoperative immune status affects postoperative survival. In summary, our results implicate prognostic and therapeutic potential, justifying further trials on the perioperative tumor immunity to maximize the benefit of surgical tumor therapy. (Source: Hormones and Cancer)
Source: Hormones and Cancer - August 23, 2023 Category: Cancer & Oncology Source Type: research
Acetylation increases expression, interaction with TRAPPC4 and surface localization of PD-L1
In this study, we showed that VPA, a class I/IIa HDAC inhibitor, upregulated PD-L1 expression on the surface of pancreatic cancer cells. To this effect contributed the increased transcription, in correlation with histone acetylation of the PD-L1 gene and the acetylation of PD-L1 protein, which led to an increased interaction with TRAPPC4, molecule involved in PD-L1 recycling to the cell membrane. Interestingly, the BRD4 inhibitor JQ-1, counteracted PD-L1 transcription and reduced its surface expression, suggesting that such a combination could improve the outcome of VPA treatment, also because it increased the cytotoxic ef...
Source: Hormones and Cancer - August 21, 2023 Category: Cancer & Oncology Source Type: research
A target map of clinical combination therapies in oncology: an analysis of clinicaltrials.gov
This study aims to capture clinical combination therapies of the validated FDA-approved new oncology drugs by a macro data analysis and to summarize combination mechanisms and strategies in the context of the existing literature. A total of 72 new molecular entities or new therapeutic biological products for cancer treatment approved by the FDA from 2017 to 2021 were identified, and the data on their related 3334 trials were retrieved from the database of ClinicalTrials.gov. Moreover, these sampled clinical trials were refined by activity status and combination relevance and labeled with the relevant clinical arms and drug...
Source: Hormones and Cancer - August 21, 2023 Category: Cancer & Oncology Source Type: research
Classification and function of γδT cells and its research progress in anti-glioblastoma
AbstractHuman peripheral blood T lymphocytes are classified into alpha –beta T (αβΤ) cells and gamma–delta T (γδΤ) cells based on the difference in T cell receptors (TCRs). αβT cells are crucial for the acquired immune response, while γδΤ cells, though only a small subset, can recognize antigenic substances. These antigens do not need to be processed and presented and are not restricted by MHC. This distinguishes γδΤ cells from αβT cells and highlights their distinct role in innate immunity. Despite their small number, γδΤ cells hold significant significance in anti-tumor, anti-infection and immune r...
Source: Hormones and Cancer - August 19, 2023 Category: Cancer & Oncology Source Type: research
The role of pyroptosis-related lncRNA risk signature in ovarian cancer prognosis and immune system
This study implies that pyroptosis-related genes are closely related to tumor immunity and could be potential therapeutic factors for ovarian cancer treatment. (Source: Hormones and Cancer)
Source: Hormones and Cancer - August 19, 2023 Category: Cancer & Oncology Source Type: research
