PTEN-related risk classification models for predicting prognosis and immunotherapy response of hepatocellular carcinoma
ConclusionsThis study demonstrated the effect of CNV on PTEN expression and the negative immune correlation of PTEN, and constructed a classification model related to the expression of PTEN, which was of guiding significance for evaluating prognostic results of HCC patients and ICB treatment response of cancer immunotherapy cohorts. (Source: Hormones and Cancer)
Source: Hormones and Cancer - July 20, 2023 Category: Cancer & Oncology Source Type: research
Evolving therapeutic landscape of diffuse large B-cell lymphoma: challenges and aspirations
AbstractDiffuse large B-cell lymphoma (DLBCL) represents the commonest subtype of non-Hodgkin lymphoma and encompasses a group of diverse disease entities, each harboring unique molecular and clinico-pathological features. The understanding of the molecular landscape of DLBCL has improved significantly over the past decade, highlighting unique genomic subtypes with implications on targeted therapy. At the same time, several new treatment modalities have been recently approved both in the frontline and relapsed settings, ending a dearth of negative clinical trials that plagued the past decade. Despite that, in the real-worl...
Source: Hormones and Cancer - July 19, 2023 Category: Cancer & Oncology Source Type: research
RIPK1 is aberrantly expressed in multiple B-cell cancers and implicated in the underlying pathogenesis
AbstractAccording to the latest epidemiology of the US, B-cell cancers account for > 3% of all new cancer cases and > 80% of non-Hodgkin lymphomas. However, the disease-modifying small molecular drug suitable for most B-cell cancers is still lacking. RIPK1 (receptor-interacting serine/threonine-protein kinase 1) has been observed to be dysregulated and implicated in the pathogenesis of multiple solid cancers, of which, however, the roles in blood cancers are quite unclear. In our study, to identify multi-function targets for B-cell cancer treatment, we reanalyzed a public transcriptomic dataset from the da...
Source: Hormones and Cancer - July 18, 2023 Category: Cancer & Oncology Source Type: research
Environmental insults and compensative responses: when microbiome meets cancer
AbstractTumor microenvironment has recently been ascribed a new hallmark —the polymorphic microbiome. Accumulating evidence regarding the tissue specific territories of tumor-microbiome have opened new and interesting avenues. A pertinent question is regarding the functional consequence of the interface between host-microbiome and cancer. Given microbial communities ha ve predominantly been explored through an ecological perspective, it is important that the foundational aspects of ecological stress and the fight to ‘survive and thrive’ are accounted for tumor-micro(b)environment as well. Building on existing evidenc...
Source: Hormones and Cancer - July 15, 2023 Category: Cancer & Oncology Source Type: research
Veillonella parvula promotes the proliferation of lung adenocarcinoma through the nucleotide oligomerization domain 2/cellular communication network factor 4/nuclear factor kappa B pathway
This study analyzed the correlation between NSCLC andV. parvula abundance based on 16 s rRNA sequencing results. The effects ofV. parvula on the progression of lung adenocarcinoma were observed in vivo and in vitro using a C57 bl/6j mouse tumor-bearing model, a bacterial cell co-culture model, combined with transcriptome sequencing, and a TCGA database to explore and validate the growth promotion of lung adenocarcinoma byV. parvula and its molecular mechanism. 16 s rRNA sequencing revealed thatV. parvula was significantly enriched in lung adenocarcinoma. In vivo,V. parvula promoted the growth of lung adenocarcinoma in ...
Source: Hormones and Cancer - July 14, 2023 Category: Cancer & Oncology Source Type: research
Emerging roles of noncoding RNAs in human cancers
AbstractStudies have found that RNA encoding proteins only account for a small part of the total number, most RNA is non-coding RNA, and non-coding RNA may affect the occurrence and development of human cancers by affecting gene expression, therefore play an important role in human pathology. At present, ncRNAs studied include miRNA, circRNA, lncRNA, piRNA, and snoRNA, etc. After decades of research, the basic role of these ncRNAs in many cancers has been clear. As far as we know, the role of miRNAs in cancer is one of the hottest research directions, however, it is also found that the imbalance of ncRNAs will affect the o...
Source: Hormones and Cancer - July 13, 2023 Category: Cancer & Oncology Source Type: research
Empagliflozin: a potential anticancer drug
In conclusion, empagliflozin has promising applications in cancer therapy as a drug for the treatment of diabetes and heart failure. This article provides a brief review of the anticancer effects of empagliflozin. (Source: Hormones and Cancer)
Source: Hormones and Cancer - July 12, 2023 Category: Cancer & Oncology Source Type: research
A pan-cancer analysis for the oncogenic role of cyclin-dependent kinase inhibitor 1B in human cancers
ConclusionsThese results showed that the levels of CDKN1B were considerably different in a number of cancer tissues, offering a potential future target for cancer therapy. (Source: Hormones and Cancer)
Source: Hormones and Cancer - July 11, 2023 Category: Cancer & Oncology Source Type: research
Construction of a novel nomogram based on competing endogenous RNAs and tumor-infiltrating immune cells for prognosis prediction in elderly patients with colorectal cancer
In conclusion, our study constructed three nomograms to predict prognosis in elderly patients with CRC, among which the ceRNA-immune cell nomogram had the best prediction accuracy. We inferred that the mechanism underlying the regulation of activated dendritic cells and mast cells by CBX6 might play a crucial role in tumor development and prognosis of elderly patients with CRC. (Source: Hormones and Cancer)
Source: Hormones and Cancer - July 10, 2023 Category: Cancer & Oncology Source Type: research
The tumor –stroma ratio and the immune microenvironment improve the prognostic prediction of pancreatic ductal adenocarcinoma
In this study, we evaluated the PDAC TME in terms of the quantity and location of cluster of differentiation (CD)4+ T cells, CD8+ T cells, macrophages, stromal maturity, and tumor-stroma ratio (TSR), as evaluated by immunohistochemical staining of serial whole-tissue sections from 116 patients with PDAC. The density of T cells and macrophages (mainly activated macrophages) was significantly higher at the invasive margins (IMs) than at the tumor center (TC). CD4+ T cells were significantly association with all the other tumor-associated immune cells (TAIs) including CD8, CD68 and CD206 positive cells. Tumors of the non-matu...
Source: Hormones and Cancer - July 5, 2023 Category: Cancer & Oncology Source Type: research
Rapid identification of endometrial hyperplasia and endometrial endometrioid cancer in young women
ConclusionsThe nomogram of EH/EC is significantly associated with risk factors, namely BMI, PCOS, anemia, infertility, menostaxis, AUB type, and endometrial thickness. The nomogram model can be used to predict the EH/EC risk and rapidly screen risk factors in a women population with high risk. (Source: Hormones and Cancer)
Source: Hormones and Cancer - July 3, 2023 Category: Cancer & Oncology Source Type: research
MUC13 promotes the development of esophageal cancer by upregulating the expression of o-glycan process-related molecules
ConclusionsThis study proved that MUC13 is an important molecule that regulates the O-glycan process and then affects the progress of esophageal cancer. MUC13 may be a novel therapeutic target for patients with esophageal cancer. (Source: Hormones and Cancer)
Source: Hormones and Cancer - July 3, 2023 Category: Cancer & Oncology Source Type: research
Perirenal fat stranding as a predictor of disease progression after radical nephroureterectomy for renal pelvic urothelial carcinoma: a retrospective study
ConclusionsPRFS of RPUC without hydronephrosis consists of collagenous fibers with M2 macrophages. The presence of ipsilateral high PRFS might be a preoperative risk factor for progression after RNU for RPUC patients without hydronephrosis. Prospective studies with large cohorts are required in the future. (Source: Hormones and Cancer)
Source: Hormones and Cancer - July 3, 2023 Category: Cancer & Oncology Source Type: research
Fusobacterium nucleatum-triggered purine metabolic reprogramming drives tumorigenesis in head and neck carcinoma
ConclusionsOur study revealed obviously aberrant purine metabolism driven byF. nucleatum in HNSCC, which was closely related to tumor progression and patient prognosis. These findings indicate the possibility of targetingF. nucleatum-induced purine metabolism reprogramming in the future treatment of HNSCC. (Source: Hormones and Cancer)
Source: Hormones and Cancer - July 2, 2023 Category: Cancer & Oncology Source Type: research
A 3-gene signature comprising CDH4, STAT4 and EBV-encoded LMP1 for early diagnosis and predicting disease progression of nasopharyngeal carcinoma
ConclusionA model combining CDH4 and STAT4 and LMP1 was proposed to be a feasible model for diagnosing NPC and predicting late stage of NPC. (Source: Hormones and Cancer)
Source: Hormones and Cancer - July 1, 2023 Category: Cancer & Oncology Source Type: research
