Research progress of exosomes in the angiogenesis of digestive system tumour
AbstractMalignant tumours of the digestive system cover a wide range of diseases that affect the health of people to a large extent. Angiogenesis is indispensable in the development, and metastasis of tumours, mainly in two ways: occupation or formation. Vessels can provide nutrients, oxygen, and growth factors for tumours to encourage growth and metastasis, so cancer progression depends on simultaneous angiogenesis. Recently, exosomes have been proven to participate in the angiogenesis of tumours. They influence angiogenesis by binding to tyrosine kinase receptors (VEGFR)-1, VEGFR-2, and VEGFR-3 with different affinities,...
Source: Hormones and Cancer - February 11, 2024 Category: Cancer & Oncology Source Type: research
The role of tumor parenchyma and brain cortex signal intensity ratio in differentiating solitary fibrous tumors and meningiomas
ConclusionAmong the many radiological and clinical distinctions between SFT and MA, TCSR ≥ 1 exhibits the highest predictive efficacy for SFT; while cranial or venous sinus invasion may be a predictor of WHO grade III SFT. (Source: Hormones and Cancer)
Source: Hormones and Cancer - February 8, 2024 Category: Cancer & Oncology Source Type: research
Research progress of Paris polyphylla in the treatment of digestive tract cancers
AbstractCancer has become one of the most important causes of human death. In particular, the 5 year survival rate of patients with digestive tract cancer is low. Although chemotherapy drugs have a certain efficacy, they are highly toxic and prone to chemotherapy resistance. With the advancement of antitumor research, many natural drugs have gradually entered basic clinical research. They ha ve low toxicity, few adverse reactions, and play an important synergistic role in the combined targeted therapy of radiotherapy and chemotherapy. A large number of studies have shown that the active components of Paris polyphylla (PP...
Source: Hormones and Cancer - February 7, 2024 Category: Cancer & Oncology Source Type: research
Analysis of clinical characteristics, treatment patterns, and outcome of patients with bilateral testicular germ cell tumors
ConclusionBGCT presents at a younger age and potentially with more advanced disease. Synchronous BGCT is diagnosed at a later stage compared to metachronous BGCT and has higher disease-specific mortality. Metachronous tumors might have a long time interval for the development of a contralateral neoplasm. The main predictor of developing an early metachronous disease is a high primary T stage. (Source: Hormones and Cancer)
Source: Hormones and Cancer - February 7, 2024 Category: Cancer & Oncology Source Type: research
CT imaging features of lung ground-glass nodule patients with upgraded intraoperative frozen pathology
ConclusionCT imaging has the capacity to effectively detect patients at risk of upstaging during FS. (Source: Hormones and Cancer)
Source: Hormones and Cancer - February 4, 2024 Category: Cancer & Oncology Source Type: research
APOB is a potential prognostic biomarker in hepatocellular carcinoma
AbstractHepatocellular carcinoma (HCC) is significantly associated with adverse prognostic outcomes. The development and progression of different types of human tumors are significantly influenced by APOB. Nevertheless, the significance and pathomechanisms of APOB in HCC have not been conclusively determined. We assessed APOB expression levels in HCC using three publicly available databases of TIMER2.0, UALCAN and Human Protein Atlas. To identify the biological function of APOB, we conducted enrichment analysis via LinkedOmics. Moreover, UALCAN was employed to assess the relationship between APOB expression and clinicopath...
Source: Hormones and Cancer - February 3, 2024 Category: Cancer & Oncology Source Type: research
PLCD3 inhibits apoptosis and promotes proliferation, invasion and migration in gastric cancer
In conclusion, PLCD3 inhibits apoptosis and promotes proliferation, invasion, and migration, which indicated that PLCD3 might serve as a therapeutic target for gastric cancer. (Source: Hormones and Cancer)
Source: Hormones and Cancer - February 2, 2024 Category: Cancer & Oncology Source Type: research
Hypofractionated versus conventional fractionation external beam radiotherapy in intermediate and high risk localized prostate cancer
ConclusionHypofractionated radiotherapy in patients with intermediate and high risk localized prostate cancer has better disease free survival at the expense of higher risk for proctitis and cystitis but no difference in overall survival as compared to conventional dose of radiation. (Source: Hormones and Cancer)
Source: Hormones and Cancer - February 2, 2024 Category: Cancer & Oncology Source Type: research
RPN1 promotes the proliferation and invasion of breast cancer cells by activating the PI3K/AKT/mTOR signaling pathway
AbstractRibophorin I (RPN1), a part of an N-oligosaccharyl-transferase complex, plays a vital role in the development of multiple cancers. However, its biological role in breast cancer has not been completely clarified. The RPN1 expression level was measured in breast cancer tissues and breast cancer cell lines (MCF7) using RT-qPCR. After down-regulating RPN1 expression by shRNA, the effects of RPN1 on the proliferation, migration and invasion of MCF7 cells were examined. Mechanistically, we assessed the effect of RPN1 on the PI3K/ AKT/mTOR signaling pathway. We found that RPN1 level was up-regulated in breast cancer tissu...
Source: Hormones and Cancer - February 1, 2024 Category: Cancer & Oncology Source Type: research
A bibliometric and visualized in oral microbiota and cancer research from 2013 to 2022
AbstractNumerous studies have highlighted the implication of oral microbiota in various cancers. However, no bibliometric analysis has been conducted on the relationship between oral microbiota and cancer. This bibliometric analysis aimed to identify the research hotspots in oral microbiota and cancer research, as well as predict future research trends. The literature published relating to oral microbiota and cancer was searched from the Web of Science Core Collection database (WoSCC) from 2013 to 2022. VOSviewer or Citespace software was used to perform the bibliometric analysis, focusing on countries, institutions, autho...
Source: Hormones and Cancer - February 1, 2024 Category: Cancer & Oncology Source Type: research
Characterization of hypoxia-responsive states in ovarian cancer to identify hot tumors and aid adjuvant therapy
ConclusionsThis work revealed that hypoxia-responsive states played an important role in formation of tumor immunogenicity. Evaluating the hypoxia-responsive state will contribute to guiding more effective immunotherapy strategies. (Source: Hormones and Cancer)
Source: Hormones and Cancer - January 31, 2024 Category: Cancer & Oncology Source Type: research
Exploring the frontiers: tumor immune microenvironment and immunotherapy in head and neck squamous cell carcinoma
AbstractThe global prevalence of head and neck malignancies positions them as the sixth most common form of cancer, with the head and neck squamous cell carcinoma (HNSCC) representing the predominant histological subtype. Despite advancements in multidisciplinary approaches and molecular targeted therapies, the therapeutic outcomes for HNSCC have only marginally improved, particularly in cases of recurrent or metastatic HNSCC (R/MHNSCC). This situation underscores the critical necessity for the development of innovative therapeutic strategies. Such strategies are essential not only to enhance the efficacy of HNSCC treatmen...
Source: Hormones and Cancer - January 31, 2024 Category: Cancer & Oncology Source Type: research
Construction and in vitro evaluation of pH-sensitive nanoparticles to reverse drug resistance of breast cancer stem cells
This study provides a nanodelivery therapy strategy that revers es BCSCs multidrug resistance (MDR) and demonstrates that it did so by interfering with cancer cell energy metabolism. Therefore, the co-delivery strategy of ATRA and SchB provides a new option for the treatment of breast cancer. (Source: Hormones and Cancer)
Source: Hormones and Cancer - January 29, 2024 Category: Cancer & Oncology Source Type: research
Long-term neurotoxicity among childhood acute lymphoblastic leukaemia survivors enrolled between 1971 and 1998 in EORTC Children Leukemia Group studies
This study is part of the larger EORTC CLG 58 Late Adverse Effects (LAE) study (ClinicalTrials.gov Identifier NCT01298388, date of registration F ebruary 16, 2011). (Source: Hormones and Cancer)
Source: Hormones and Cancer - January 29, 2024 Category: Cancer & Oncology Source Type: research
Clinical importance of serum miRNA levels in breast cancer patients
AbstractThere is limited data on the relationship of miRNAs with parameters that may affect surgical management or reflect tumour prognosis. It was aimed to evaluate serum miRNA levels in breast carcinoma cases and reveal the relationship between these levels and prognosis-related factors such as the histological type of the tumour, estrogen receptor, progesterone receptor, Ki-67 index, HER-2neu, E-cadherin, tumour size, CK5/6, CA15.3 levels, number of tumour foci, number of metastatic lymph nodes, and status of receiving neoadjuvant therapy. Thirty-five patients with a histopathologically confirmed breast carcinoma diagno...
Source: Hormones and Cancer - January 27, 2024 Category: Cancer & Oncology Source Type: research
