SDH mutations, as potential predictor of chemotherapy prognosis in small cell lung cancer patients
ConclusionOur results provide a potential stratification of chemotherapy prognosis in SCLC patients, and have certain guiding significance for subsequent precise targeted therapy. (Source: Hormones and Cancer)
Source: Hormones and Cancer - June 5, 2023 Category: Cancer & Oncology Source Type: research
Anal lymphoma: a tumor with insufficient attention
ConclusionAnal lymphoma is extremely rare. Patients with persistent abscess complicated with HIV or EBV infection should undergo pathological biopsy to exclude anal lymphoma. (Source: Hormones and Cancer)
Source: Hormones and Cancer - June 5, 2023 Category: Cancer & Oncology Source Type: research
CircHIPK3 negatively regulates autophagy by blocking VCP binding to the Beclin 1 complex in bladder cancer
AbstractCircular RNA HIPK3 (circHIPK3) mediates the progression of multiple cancers, including bladder cancer, by regulating cell migration, autophagy and epithelial mesenchymal transition. However, the mechanism by which circHIPK3 regulates autophagy in bladder cancer cells remains unclear. Autophagy is a common self-protection mechanism in eukaryotic cells and is essential for cell survival and death regulation. However, it is unclear whether circHIPK3 affects the level of autophagy in bladder cancer through binding proteins, and the potential regulatory mechanism is unknown. Here, we found that circHIPK3 levels were sig...
Source: Hormones and Cancer - June 3, 2023 Category: Cancer & Oncology Source Type: research
Tetrandrine citrate suppresses lung adenocarcinoma growth via SLC7A11/GPX4-mediated ferroptosis
In conclusion, our study first identified the mechanism by which TetC-induced ferroptosis in LUAD via SLC7A11/GPX4 signaling. (Source: Hormones and Cancer)
Source: Hormones and Cancer - June 2, 2023 Category: Cancer & Oncology Source Type: research
Anticancer efficacy of hirsuteine against colorectal cancer by opposite modulation of wild-type and mutant p53
ConclusionThis study revealed the anticancer efficacy of HST against CRC via opposite modulation of wtp53 and mutp53R273H, indicating the potential of HST to be a CRC drug candidate targeting p53 signaling. (Source: Hormones and Cancer)
Source: Hormones and Cancer - May 31, 2023 Category: Cancer & Oncology Source Type: research
