Identification and validation of a novel six-gene signature based on mucinous adenocarcinoma-related gene molecular typing in colorectal cancer
ConclusionMAC-related genes were able to classify CRC. A RiskScore signature based on the colorectal MAC-related molecular subtype was constructed, which had important clinical significance for guiding the accurate stratification of CRC patients. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 5, 2024 Category: Cancer & Oncology Source Type: research
The impact of radiomics in the management of soft tissue sarcoma
ConclusionsWith an increasing interest over the last years, the use of radiomics appears to have potential for assessing STSs from initial diagnosis to predicting treatment response. However, additional and extensive research is necessary to validate the effectiveness of radiomics parameters and to integrate them into a comprehensive decision support system. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 5, 2024 Category: Cancer & Oncology Source Type: research
Unveiling NUSAP1 as a common gene signature linking chronic HBV infection and HBV-related HCC
ConclusionNUSAP1 serves as a poor prognostic indicator for liver cancers, and potentially plays a crucial role in HBV-HCC progression by promoting proliferation and inhibiting apoptosis. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 5, 2024 Category: Cancer & Oncology Source Type: research
Low serum total cholesterol levels predict inferior prognosis of patients with POEMS syndrome
In conclusion, low serum TC levels may predict inferior prognosis in patients with POEMS syndrome; in future clinical application, low TC may be a reliable indicator of prognosis. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 4, 2024 Category: Cancer & Oncology Source Type: research
Causal relationship between gut microbiota and prostate cancer contributes to the gut-prostate axis: insights from a Mendelian randomization study
ConclusionThis MR study lends support to a causal relationship between genetically predicted gut microbiota and prostate cancer. Research on the gut-prostate axis, along with further multi-omics analyses, holds significant implications for the prevention and treatment of prostate cancer. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 3, 2024 Category: Cancer & Oncology Source Type: research
The prevalence of ADSL (rs3788579) and CYP1A2 (rs17861162) polymorphisms in female breast cancer patients in North-West Iran
ConclusionThis study highlights significant genetic alterations in CYP1A2-rs17861162 and ADSL-rs3788579 SNPs among breast cancer patients in North-West Iran, suggesting their potential as diagnostic and prognostic biomarkers. Further research is warranted to elucidate the precise mechanisms underlying their contributions to breast cancer susceptibility in this population. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 3, 2024 Category: Cancer & Oncology Source Type: research
The prognostic value of LAYN in HPV-related head and neck squamous cell carcinoma and its influence on immune cell infiltration
ConclusionsLAYN might contribute to tumorigenesis via its positive correlation with immune checkpoint molecules and tumor-associated macrophages (TAMs). Our study might provide a novel prognostic biomarker and latent therapeutic target for the treatment of HPV-related HNSCC. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 2, 2024 Category: Cancer & Oncology Source Type: research
Comprehensive analysis of T cell exhaustion related signature for predicting prognosis and immunotherapy response in HNSCC
ConclusionIn conclusion, we developed a novel T cell exhaustion-associated signature, which holds considerable predictive value for both the prognosis of patients with HNSCC and the effectiveness of tumor immunotherapy. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 2, 2024 Category: Cancer & Oncology Source Type: research
Effects of different surgical approaches on health-related quality of life in pediatric and adolescent patients with papillary thyroid carcinoma
ConclusionFor children and adolescents with papillary thyroid carcinoma at low risk of recurrence, bilateral thyroidectomy is associated with a lower HRQOL than unilateral thyroidectomy. Surgeons should consider tumor impact and HRQOL when selecting the most appropriate surgical method. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 2, 2024 Category: Cancer & Oncology Source Type: research
The impact of different clinicopathologic factors and salvage therapies on cervical cancer patients with isolated para-aortic lymph node recurrence
ConclusionIn cervical cancer patients with isolated PALN recurrence, chemoradiotherapy or surgery ± adjuvant therapy may be preferred as the salvage treatment. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 1, 2024 Category: Cancer & Oncology Source Type: research
Comprehensive analysis of DNA methylation gene expression profiles in GEO dataset reveals biomarkers related to malignant transformation of sinonasal inverted papilloma
ConclusionsBy analyzing the methylation dataset, we obtained four up-regulated methylation genes UCKL1, GSTT1, HLA-G and MAML2 and one down-regulated gene NRGN. MAML2, a tumor suppressor gene with high methylation modification but loss of protein expression, and NRGN, a tumor gene with low methylation modification but upregulated protein expression, can be used as biological indicators to judge the malignant transformation of SNIP-SCC. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 1, 2024 Category: Cancer & Oncology Source Type: research
The mechanism of action and experimental verification of Gan-song Yin on renal clear cell carcinoma based on network pharmacology and bioinformatics
ConclusionsNetwork pharmacology and bioinformatics analysis showed that GSY could act on multiple targets through a variety of components to achieve the effect of treating KIRC. In this study, we confirmed that GSY inhibits KIRC by regulating the expression of core targets through in vitro cellular experiments, thus providing a reference for subsequent related studies. (Source: Hormones and Cancer)
Source: Hormones and Cancer - February 28, 2024 Category: Cancer & Oncology Source Type: research
Expression and prognosis analysis of TBX2 subfamily in human lung carcinoma
ConclusionOur research provided sufficient evidence thatTBX2 subfamily might play an inhibitory role in malignancy progression of lung cancer, which is promising to shed light on discovering a novel reliable cancer marker for prognosis of lung cancer patients. (Source: Hormones and Cancer)
Source: Hormones and Cancer - February 27, 2024 Category: Cancer & Oncology Source Type: research
Prognostic significance of LINC01132 in lung cancer and its regulatory role in tumor progression
ConclusionLINC01132 may regulate the progression of lung cancer by targeting the miR-125a-3p /SMAD2 axis and serve as a prognostic biomarker for lung cancer. (Source: Hormones and Cancer)
Source: Hormones and Cancer - February 25, 2024 Category: Cancer & Oncology Source Type: research
Visual conservation treatment dilemmas in neuroblastoma with bilateral blindness
ConclusionNeuroblastoma with bilateral blindness is rare in the clinic, mostly in children of young age, and is often associated withMYCN amplification and multiple metastases. Early hormone shock therapy and optic nerve decompression are beneficial for preserving the child ’s vision. A joint multi-disciplinary treatment may help in the formulation of treatment decisions. Achieving a balance between good visual preservation and survival within the short optic nerve neurotherapeutic window is extremely challenging. (Source: Hormones and Cancer)
Source: Hormones and Cancer - February 25, 2024 Category: Cancer & Oncology Source Type: research
