TERT mutations-associated alterations in clinical characteristics, immune environment and therapy response in glioblastomas
ConclusionMutations in TERT alter the local immune environment and decrease the sensitivity of GBM to chemotherapy. (Source: Hormones and Cancer)
Source: Hormones and Cancer - August 11, 2023 Category: Cancer & Oncology Source Type: research
Identification of hepatocellular carcinoma-related subtypes and development of a prognostic model: a study based on ferritinophagy-related genes
ConclusionThis study identifies a considerable impact of FRGs on immunity and prognosis in individuals with LIHC. The collective findings of this research provide new ideas for personalized treatment of LIHC and a more targeted therapy approach for individuals with LIHC to improve their prognosis. (Source: Hormones and Cancer)
Source: Hormones and Cancer - August 9, 2023 Category: Cancer & Oncology Source Type: research
Case report: a successful treatment with immune checkpoint inhibitors was associated with severe dermatologic toxicities in a patient with double primary malignancies
We report a case of a 75-year-old man with non-small cell lung cancer (NSCLC) and prostate cancer with a Stevens-Johnson syndrome (SJS)-like eruption. The severe rash might have been induced by resuming pembrolizumab was successfully treated with a combination of corticosteroids, gamma globulin, and immunosuppressants. Early detection of dermatologic toxicity is crucial, especially for patients receiving multiple antitumor treatments. We should treat ICI resumption seriously after skin irAE. (Source: Hormones and Cancer)
Source: Hormones and Cancer - August 8, 2023 Category: Cancer & Oncology Source Type: research
Long noncoding RNA CASC11 suppresses sorafenib-triggered ferroptosis via stabilizing SLC7A11 mRNA in hepatocellular carcinoma cells
AbstractAs a frontline treatment for patients with advanced hepatocellular carcinoma (HCC), sorafenib is an effective drug approved by the Food and Drug Administration (FDA). Ferroptosis, a newly defined programmed cell death process with the hallmark of the accumulation of iron-dependent lipid peroxides, can be induced by sorafenib treatment. Our previous study identified oncogenic roles of long noncoding RNA (lncRNA) Cancer susceptibility candidate 11 (CASC11) in HCC progression. However, the relationship between CASC11 and sorafenib-induced ferroptosis in HCC remains unclear. In the present study, we aim to investigate ...
Source: Hormones and Cancer - August 8, 2023 Category: Cancer & Oncology Source Type: research
DNAJB4 suppresses breast cancer progression and promotes tumor immunity by regulating the Hippo signaling pathway
ConclusionsThe present study demonstrated that DNAJB4 overexpression inhibited the malignant biological behavior of breast cancer by regulating the Hippo pathway and tumor immunosuppressive environment. (Source: Hormones and Cancer)
Source: Hormones and Cancer - August 7, 2023 Category: Cancer & Oncology Source Type: research
Prognostic value of the combined preoperative plasma fibrinogen and systemic inflammatory indexes in ESCC patients
AbstractThe prognostic indexes based on the combination of preoperative fibrinogen and systemic inflammatory indexes may have greater predictive value in esophageal squamous cell carcinoma (ESCC). It was found that the predictive ability of F-NLR was more valuable than other systemic inflammatory indexes. The preoperative F-NLR score was closely related to the TNM stage, and could be used as an important independent prognostic index for patients with ESCC. Then the nomogram model constructed by F-NLR and TNM stage had higher prognostic ability than that of AJCC stage for ESCC patients. Preoperative F-NLR is a new independe...
Source: Hormones and Cancer - August 4, 2023 Category: Cancer & Oncology Source Type: research
Circulating noncoding RNAs: promising biomarkers in liquid biopsy for the diagnosis, prognosis, and therapy of NSCLC
AbstractAs the second most common malignant tumor in the world, lung cancer is a great threat to human health. In the past several decades, the role and mechanism of ncRNAs in lung cancer as a class of regulatory RNAs have been studied intensively. In particular, ncRNAs in body fluids have attracted increasing attention as biomarkers for lung cancer diagnosis and prognosis and for the evaluation of lung cancer treatment due to their low invasiveness and accessibility. As emerging tumor biomarkers in lung cancer, circulating ncRNAs are easy to obtain, independent of tissue specimens, and can well reflect the occurrence and ...
Source: Hormones and Cancer - August 1, 2023 Category: Cancer & Oncology Source Type: research
The therapeutic targets of N6-methyladenosine (m6A) modifications on tumor radioresistance
AbstractRadiation therapy is an important tool for malignant tumors, and its tolerance needs to be addressed. In recent years, several studies have shown that regulators of aberrant m6A methylation play an important role in the formation, development and invasion and metastasis of tumors. A large number of studies have confirmed aberrant m6A methylation as a new target for tumour therapy, but research on whether it can play a role in tumor sensitivity to radiotherapy has not been extensive and thorough enough. Recent studies have shown that all three major enzymes of m6A methylation have significant roles in radioresistanc...
Source: Hormones and Cancer - July 31, 2023 Category: Cancer & Oncology Source Type: research
GPR81-mediated reprogramming of glucose metabolism contributes to the immune landscape in breast cancer
ConclusionGlucometabolic reprogramming through a GPR81-mediated Hippo-YAP signaling pathway was responsible for the distinct immune landscape in BC. GPR81 was a potential biomarker to stratify patients before immunotherapy to improve BC ’s clinical prospect. (Source: Hormones and Cancer)
Source: Hormones and Cancer - July 27, 2023 Category: Cancer & Oncology Source Type: research
Artesunate alleviates 5-fluorouracil-induced intestinal damage by suppressing cellular senescence and enhances its antitumor activity
ConclusionsOverall, our findings point to the crucial treatment effect of Arte on inflammation, intestinal cell senescence, and CRC cell proliferation and offer a new option for CRC treatment. (Source: Hormones and Cancer)
Source: Hormones and Cancer - July 27, 2023 Category: Cancer & Oncology Source Type: research
Antitumor activity of 5-fluorouracil polymeric nanogel synthesized by gamma radiation on a rat model of colon carcinoma: a proposed mechanism
Conclusion: Collectively, these data might strength en the therapeutic potential of 5-FU nanogel which can be used as an antitumor product for colon cancer. (Source: Hormones and Cancer)
Source: Hormones and Cancer - July 26, 2023 Category: Cancer & Oncology Source Type: research
Propofol inhibits colon cancer cell stemness and epithelial-mesenchymal transition by regulating SIRT1, Wnt/ β-catenin and PI3K/AKT/mTOR signaling pathways
ConclusionPropofol inhibits LOVO and SW480 cell stemness and EMT by regulating SIRT1 and the Wnt/ β-catenin and PI3K/AKT/mTOR signaling pathways. Our findings indicate that propofol inhibits SIRT1 in cancer and is advantageous in colon cancer surgical treatment of patients with high SIRT1 expression. (Source: Hormones and Cancer)
Source: Hormones and Cancer - July 25, 2023 Category: Cancer & Oncology Source Type: research
WNT ligands in non-small cell lung cancer: from pathogenesis to clinical practice
AbstractNon-small cell lung cancer (NSCLC) is the malignant tumor with the highest morbidity and leading cause of death worldwide, whereas its pathogenesis has not been fully elucidated. Although mutations in some crucial genes in WNT pathways such as β-catenin and APC are not common in NSCLC, the abnormal signal transduction of WNT pathways is still closely related to the occurrence and progression of NSCLC. WNT ligands (WNTs) are a class of secreted glycoproteins that activate WNT pathways through binding to their receptors and play important regulatory roles in embryonic development, cell differentiation, and tissue re...
Source: Hormones and Cancer - July 24, 2023 Category: Cancer & Oncology Source Type: research
The activity of cuproptosis pathway calculated by AUCell algorithm was employed to construct cuproptosis landscape in lung adenocarcinoma
In this study, data from 503 patients with lung cancer from the TCGA-LUAD cohort data collection and 11 LUAD single-cells from GSE131907 as well as from 10 genes associated with cuproptosis were analyzed. The AUCell R package was used to determine the copper-dependent cell death pathway activity for each cell subpopulation, calculate the CellChat score, and display cell communication for each cell subpopulation. The PROGENy score was calculated to show the scores of tumor-related pathways in different cell populations. GO and KEGG analyses were used to calculate pathway activity. Univariate COX and random forest analyses w...
Source: Hormones and Cancer - July 23, 2023 Category: Cancer & Oncology Source Type: research
Multiparametric MRI radiomics in prostate cancer for predicting Ki-67 expression and Gleason score: a multicenter retrospective study
ConclusionsBoth Ki-67 expression status and high GS correlate with PCa patient survival outcomes; therefore, the ability of the SVM classifier-based model to estimate Ki-67 expression status and the Lasso classifier-based model to assess high GS may enhance clinical decision-making. (Source: Hormones and Cancer)
Source: Hormones and Cancer - July 20, 2023 Category: Cancer & Oncology Source Type: research
