Propofol inhibits colon cancer cell stemness and epithelial-mesenchymal transition by regulating SIRT1, Wnt/ β-catenin and PI3K/AKT/mTOR signaling pathways

ConclusionPropofol inhibits LOVO and SW480 cell stemness and EMT by regulating SIRT1 and the Wnt/ β-catenin and PI3K/AKT/mTOR signaling pathways. Our findings indicate that propofol inhibits SIRT1 in cancer and is advantageous in colon cancer surgical treatment of patients with high SIRT1 expression.
Source: Hormones and Cancer - Category: Cancer & Oncology Source Type: research