L-cysteine contributes to destructive activities of odontogenic cysts/tumor
ConclusionHigh-throughput targeted metabolomics performed on diseased tissue confirmed the unique alteration of metabolic profiles in OKC and AM. CTH and its metabolite L-cysteine are the key factors regulating destructive activities. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 8, 2024 Category: Cancer & Oncology Source Type: research
Relationship of mTORC1 and ferroptosis in tumors
AbstractFerroptosis is a novel form of programmed death, dependent on iron ions and oxidative stress, with a predominant intracellular form of lipid peroxidation. In recent years, ferroptosis has gained more and more interest of people in the treatment mechanism of targeted tumors. mTOR, always overexpressed in the tumor, and controlling cell growth and metabolic activities, has an important role in both autophagy and ferroptosis. Interestingly, the selective types of autophay plays an important role in promoting ferroptosis, which is related to mTOR and some metabolic pathways (especially in iron and amino acids). In this...
Source: Hormones and Cancer - April 7, 2024 Category: Cancer & Oncology Source Type: research
Morbidity and mortality of patients with peritoneal malignancy following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
ConclusionsThe morbidity rate in patients undergoing CRS + HIPEC is acceptable compared to morbidity of previous publications or major gastrointestinal surgical operations. The possible prognostic variables of morbidity are the extent of peritoneal malignancy, and the number of suture lines. The mortality rate is low. The possible prognostic variable s of mortality are the number of FFP units, and the number of peritonectomy procedures. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 5, 2024 Category: Cancer & Oncology Source Type: research
Efficacy and safety of lenalidomide in the treatment of B-cell non-Hodgkin lymphoma
ConclusionsLenalidomide appears to be a promising therapeutic agent that offers the possibility of a novel combination of chemotherapy free regimen for patients with B-cell non-Hodgkin lymphoma. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 5, 2024 Category: Cancer & Oncology Source Type: research
Identification of immune-associated biomarker for predicting lung adenocarcinoma: bioinformatics analysis and experiment verification of PTK6
ConclusionPTK6 has predictive value for LUAD prognosis, and could up regulated PD-L1. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 4, 2024 Category: Cancer & Oncology Source Type: research
Fibrin glue mediated direct delivery of radiation sensitizers results in enhanced efficacy of radiation treatment
ConclusionNon-degraded RS was released from the FG for up to 72 h. FG-released 5FU greatly increased the efficacy of radiation therapy. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 4, 2024 Category: Cancer & Oncology Source Type: research
Giant cell tumor of bone at distal radius suffered more soft tissue recurrence and ultrasonography is effective to detect the soft tissue recurrence
ConclusionsSoft tissue recurrence of GCTB may recur for more than once and distal radius was the most common location of primary GCTB that would suffer a soft tissue recurrence. Ultrasonography was a useful method to detect the recurrence. Since no risk factors were discovered, a careful follow-up with ultrasonography was recommended. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 4, 2024 Category: Cancer & Oncology Source Type: research
Outcomes of thyroidectomy for secondary thyroid malignancies, a single center experience
ConclusionsMetastasis to the thyroid gland is a rare phenomenon with an incidence of 0.22% in all thyroid malignancies. It may occur before the detection of the primary tumor or during the follow-up of the primary malignancy. Although the overall prognosis is poor, it can be treated surgically. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 4, 2024 Category: Cancer & Oncology Source Type: research
Development of chitosan-folate modified PLGA nanoparticles for targeted delivery of diosgenin as an anticancer agent
AbstractDiosgenin as a potential phytoconstituent and steroidal saponin manifested significant anticancer agents against various cancers. To enhance its solubility and bioavailability in cancer treatment, we loaded diosgenin (PubChem CID: 99474) in poly(lactic-co-glycolide) (PLGA) nanoparticle coated with folic aci d-chitosan (Da-PFC-NPs). The diosgenin nano-formulation was characterized and its antioxidant and anticancer properties were surveyed respectively. The obtained results illustrated that the Da-PFC-NPs were spherical and stable with a size of 218 nm and a polydispersity index of 0.41. The Da-PFC-NP s indicate...
Source: Hormones and Cancer - April 3, 2024 Category: Cancer & Oncology Source Type: research
MAP3K4 kinase action and dual role in cancer
AbstractIt is commonly known that the MAPK pathway is involved in translating environmental inputs, regulating downstream reactions, and maintaining the intrinsic dynamic balance. Numerous essential elements and regulatory processes are included in this pathway, which are essential to its functionality. Among these, MAP3K4, a member of the serine/threonine kinases family, plays vital roles throughout the organism's life cycle, including the regulation of apoptosis and autophagy. Moreover, MAP3K4 can interact with key partners like GADD45, which affects organism's growth and development. Notably, MAP3K4 functions as both a ...
Source: Hormones and Cancer - April 3, 2024 Category: Cancer & Oncology Source Type: research
BRD4 inhibitors broadly promote erastin-induced ferroptosis in different cell lines by targeting ROS and FSP1
AbstractFerroptosis, an iron-dependent form of programmed cell death, is a promising strategy for cancer treatment. Bromodomain-containing protein 4 (BRD4) is an epigenetic reader and a promising target for cancer therapeutics. However, the role of BRD4 in ferroptosis is controversial and the value of the interaction between BRD4 inhibitors and ferroptosis inducers remains to be explored. Here, we found that BRD4 inhibition greatly enhanced erastin-induced ferroptosis in different types of cells, including HEK293T, HeLa, HepG2, RKO, and PC3 cell lines. Knocking downBRD4 in HEK293T and HeLa cells also promoted erastin-induc...
Source: Hormones and Cancer - April 3, 2024 Category: Cancer & Oncology Source Type: research
The combined effect of MTHFR C677T and A1298C polymorphisms on the risk of digestive system cancer among a hypertensive population
ConclusionThese findings indicate a potential protective effect against digestive system cancer associated with the T allele ofMTHFR C677T. Moreover, we observed that the presence of different combinations ofMTHFR polymorphisms may contribute to varying susceptibilities to digestive system cancer. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 2, 2024 Category: Cancer & Oncology Source Type: research
Immunohistochemical and molecular profiles of heterogeneous components of metaplastic breast cancer: a squamous cell carcinomatous component was distinct from a spindle cell carcinomatous component
In conclusion, the immunohistochemical and molecular profiles of the SCC(c) of MBC are distinct from those of the SpCC(c). (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 2, 2024 Category: Cancer & Oncology Source Type: research
Cyclovirobuxine D inhibits hepatocellular carcinoma growth by inducing ferroptosis of hepatocellular carcinoma cells
ConclusionCVB-D suppresses the growth in HCC cells through ferroptosis. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 2, 2024 Category: Cancer & Oncology Source Type: research
Primary squamous cell carcinoma of the breast: a case report
ConclusionSCC of the breast with spindle cell and sarcomatoid features is rare. The diagnosis of such tumors requires exclusion of tumors with similar histological morphologies. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 1, 2024 Category: Cancer & Oncology Source Type: research
