The adverse outcome pathway for breast cancer: a knowledge management framework bridging biomedicine and toxicology
AbstractBreast cancer is the most common cancer worldwide, with an estimated 2.3 million new cases diagnosed every year. Effective measures for cancer prevention and cancer therapy require a detailed understanding of the individual key disease mechanisms involved and their interactions at the molecular, cellular, tissue, organ, and organism level. In that regard, the rapid progress of biomedical and toxicological research in recent years now allows the pursuit of new approaches based on non-animal methods that provide greater mechanistic insight than traditional animal models and therefore facilitate the development of Adv...
Source: Hormones and Cancer - December 5, 2023 Category: Cancer & Oncology Source Type: research
Resection margins, lymph node harvest and 3 year survival in open and laparoscopic colorectal cancer surgery; a prospective cohort study
This study was aimed at comparing the lymph node (LN) clearance and surgical resection margins and 3-year survival for open and laparoscopic colorectal cancer surgery.MethodA pre-tested interviewer administered questionnaire was used to assess the adoption of the laparoscopic approach by Sri Lankan surgeons. Data was collected prospectively from patients who underwent open or laparoscopic colorectal cancer surgery at the University Surgical Unit of the National Hospital of Sri Lanka from April 2016 to May 2019. The histopathology records were analysed to determine the longitudinal and circumferential resection margins(CRM)...
Source: Hormones and Cancer - December 3, 2023 Category: Cancer & Oncology Source Type: research
Clinical application of 192Ir High-Dose-Rate brachytherapy in metastatic lymph nodes of the neck
ConclusionsHigh-dose-rate brachytherapy serves as a safe and effective method in treating recurrent residual neck metastatic lymph nodes in the field after external radiotherapy, exerting tolerable adverse effects. (Source: Hormones and Cancer)
Source: Hormones and Cancer - December 1, 2023 Category: Cancer & Oncology Source Type: research
Breast cancer stem cells generate immune-suppressive T regulatory cells by secreting TGF β to evade immune-elimination
In conclusion, during initiation as well as after chemotherapy, when NSCCs are not present in the tumor microenvironment, CSCs, albeit present in low numbers, generate immunosuppressive CD4+CD25+FOXP3+ Treg cells in a contact-independent manner by shedding high levels of immune-suppressive Treg-polarizing cytokine TGF β, thus escaping immune-elimination and initiating the tumor or causing tumor relapse. (Source: Hormones and Cancer)
Source: Hormones and Cancer - December 1, 2023 Category: Cancer & Oncology Source Type: research
Mitophagy genes in ovarian cancer: a comprehensive analysis for improved immunotherapy
ConclusionOur comprehensive analysis of MRGs in the TME, clinical features, and patient prognosis revealed that the MRG_score is a potentially effective prognostic biomarker and predictor of treatment. This study provides new insights into the role of MRGs in OV and identifies patients who may benefit from ICI treatment, chemotherapy, or targeted treatment. (Source: Hormones and Cancer)
Source: Hormones and Cancer - December 1, 2023 Category: Cancer & Oncology Source Type: research
Dynamic estimates of survival in oncocytic cell carcinoma of the thyroid
ConclusionsPrognosis improved over time in patients with OCC. The largest increase in conditional DSS was observed in patients with distant disease. Conditional survival may provide more relevant prognostic information than conventional survival estimates and allow personalized follow-up and counseling. (Source: Hormones and Cancer)
Source: Hormones and Cancer - November 30, 2023 Category: Cancer & Oncology Source Type: research
Deep-learning-based survival prediction of patients with lower limb melanoma
ConclusionWe created the DeepSurv model using LLM patient data from the SEER database, which performed better than the CoxPH model in predicting the survival time of LLM patients. (Source: Hormones and Cancer)
Source: Hormones and Cancer - November 30, 2023 Category: Cancer & Oncology Source Type: research
β-Arrestin2 promotes docetaxel resistance of castration-resistant prostate cancer via promoting hnRNP A1-mediated PKM2 alternative splicing
ConclusionOur findings indicate that the β-arrestin2/hnRNP A1/PKM2 pathway could be a promising target for treating docetaxel-resistant CRPC. (Source: Hormones and Cancer)
Source: Hormones and Cancer - November 29, 2023 Category: Cancer & Oncology Source Type: research
Functional and nonfunctional parathyroid carcinoma: two case reports and literature review
AbstractParathyroid carcinoma (PC) is a rare malignant endocrine tumor. It can be divided into functional and non-functional types according to the tumor ’s ability to secrete parathyroid hormone. Herein, we present a case each of functional and nonfunctional PC. Case 1: Functional PC. The main clinical symptoms were high parathyroid hormone and hypercalcemia with bone injury and other complications. The mass was large, capsulated, and showed vascu lar invasion. The tumor was surgically removed, along with a part of the tracheal wall and recurrent laryngeal nerve that were invaded by the tumor. The ipsilateral and isthmu...
Source: Hormones and Cancer - November 29, 2023 Category: Cancer & Oncology Source Type: research
ARAP1 negatively regulates stress fibers formation and metastasis in lung adenocarcinoma via controlling Rho signaling
AbstractSmall GTPases regulate multiple important cellular behaviors and their activities are strictly controlled by a mass of regulators. The dysfunction or abnormal expression of small GTPases or their regulators was frequently observed in various cancers. Here, we analyzed the expression and prognostic correlation of several GTPases and related regulators based on the TCGA database and found that Ankyrin Repeat and PH Domain 1 (ARAP1), a GTPase activating protein (GAP), is reduced in lung adenocarcinoma tissues compared to normal tissues and displays a positive correlation with overall survival (OS) and progression-free...
Source: Hormones and Cancer - November 27, 2023 Category: Cancer & Oncology Source Type: research
Mapping the immunological battlefield in gastric cancer: prognostic implications of an immune gene expression signature
ConclusionOur study identified DEIRGs and established a prognostic index (IRGPI) for GC patients. The IRGPI exhibited promising prognostic potential and provided insights into GC tumor biology and immune characteristics. These findings have implications for guiding therapeutic strategies. (Source: Hormones and Cancer)
Source: Hormones and Cancer - November 24, 2023 Category: Cancer & Oncology Source Type: research
Development and validation of a radiomics nomogram for diagnosis of malignant pleural effusion
ConclusionThis study presents a nomogram model incorporating CT scan features and radiomics features to help physicians differentiate MPE from BPE. (Source: Hormones and Cancer)
Source: Hormones and Cancer - November 24, 2023 Category: Cancer & Oncology Source Type: research
Comparison of clinical characteristics and prognosis between type I and type II endometrial cancer: a single-center retrospective study
ConclusionType II patients shared different clinical characteristics and worse prognosis compared to type I, and their independent risk and protective factors also varied. (Source: Hormones and Cancer)
Source: Hormones and Cancer - November 23, 2023 Category: Cancer & Oncology Source Type: research
ALOX5AP is a new prognostic indicator in acute myeloid leukemia
ConclusionALOX5AP overexpression, associated with its hypomethylation, predicts poorer prognosis in AML. (Source: Hormones and Cancer)
Source: Hormones and Cancer - November 23, 2023 Category: Cancer & Oncology Source Type: research
Effects of HepaSphere microsphere encapsule epirubicin with a new loading method transarterial chemoembolization: in vitro and in vivo experiments
ConclusionsThe size of HS microsphere can be effectively reduced when it is loaded with a mixture of hypertonic saline and non-ionic contrast material. HS microsphere loaded with epirubicin using the new method (ndTACE) can increase the drug concentration in tumor and hence exert better improved antitumor effect. (Source: Hormones and Cancer)
Source: Hormones and Cancer - November 22, 2023 Category: Cancer & Oncology Source Type: research
