Management strategies for common viral infections in pediatric renal transplant recipients
World J Transplant. 2024 Mar 18;14(1):89978. doi: 10.5500/wjt.v14.i1.89978.ABSTRACTViral infections have been considered as a major cause of morbidity and mortality after kidney transplantation in pediatric cohort. Children are at high risk of acquiring virus-related complications due to immunological immaturity and the enhanced alloreactivity risk that led to maintenance of high immunosuppressive regimes. Hence, prevention, early detection, and prompt treatment of such infe ctions are of paramount importance. Among all viral infections, herpes viruses (herpes simplex virus, varicella zoster virus, Epstein-Barr virus, cyto...
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Randula Ranawaka Kavinda Dayasiri Erandima Sandamali Manoji Gamage Source Type: research
The effects of urolithin A on poly I:C-induced microglial activation
Front Cell Neurosci. 2024 Mar 20;18:1343562. doi: 10.3389/fncel.2024.1343562. eCollection 2024.ABSTRACTNeuroinflammation can be triggered by various stimuli, including viral infections. Viruses can directly invade the brain and infect neuronal cells or indirectly trigger a "cytokine storm" in the periphery that eventually leads to microglial activation in the brain. While this initial activation of microglial cells is important for viral clearance, chronic activation leads to excessive inflammation and oxidative stress, which can be neurotoxic. Remarkebly, recent studies have shown that certain viruses such as influenza A ...
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Yakum Benard Mingo Lea Gabele Niklas Lonnemann Bert Br ône Martin Korte Shirin Hosseini Source Type: research
Resolution of metastatic neck nodes associated with a periauricular cutaneous squamous cell carcinoma after intranodal injection of talimogene laherparepvec
JAAD Case Rep. 2024 Feb 18;46:92-94. doi: 10.1016/j.jdcr.2024.02.008. eCollection 2024 Apr.NO ABSTRACTPMID:38577494 | PMC:PMC10992271 | DOI:10.1016/j.jdcr.2024.02.008 (Source: Herpes)
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Yonglu Che Curtis Chong Marketa Limova Laura Morris Sunil Arani Reddy Anne Lynn S Chang Source Type: research
Ruxolitinib associated psoas muscle tuberculosis abscess in a primary myelofibrosis woman: A case report and literature review
Medicine (Baltimore). 2024 Apr 5;103(14):e37653. doi: 10.1097/MD.0000000000037653.ABSTRACTRATIONALE: Primary myelofibrosis is a subtype of myeloproliferative neoplasm that leads to bone marrow fibrosis. Historically, the only curative option for primary myelofibrosis was allogeneic hematopoietic stem cell transplant. Ruxolitinib, a Janus kinase inhibitor, is now used for the treatment of primary myelofibrosis and polycythemia vera. It effectively improves symptoms related to splenomegaly and anemia. However, its association with the development of opportunistic infections has been observed in clinical studies and practical...
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Chi-Yu Chen Tun-Chieh Chen Source Type: research
New hopes for the breast cancer treatment: perspectives on the oncolytic virus therapy
Front Immunol. 2024 Mar 21;15:1375433. doi: 10.3389/fimmu.2024.1375433. eCollection 2024.ABSTRACTOncolytic virus (OV) therapy has emerged as a promising frontier in cancer treatment, especially for solid tumours. While immunotherapies like immune checkpoint inhibitors and CAR-T cells have demonstrated impressive results, their limitations in inducing complete tumour regression have spurred researchers to explore new approaches targeting tumours resistant to current immunotherapies. OVs, both natural and genetically engineered, selectively replicate within cancer cells, inducing their lysis while sparing normal tissues. Rec...
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Hanna Chowaniec Antonina Ślubowska Magdalena Mroczek Martyna Borowczyk Ma łgorzata Braszka Grzegorz Dworacki Paula Dobosz Mateusz Wichtowski Source Type: research
Management strategies for common viral infections in pediatric renal transplant recipients
World J Transplant. 2024 Mar 18;14(1):89978. doi: 10.5500/wjt.v14.i1.89978.ABSTRACTViral infections have been considered as a major cause of morbidity and mortality after kidney transplantation in pediatric cohort. Children are at high risk of acquiring virus-related complications due to immunological immaturity and the enhanced alloreactivity risk that led to maintenance of high immunosuppressive regimes. Hence, prevention, early detection, and prompt treatment of such infe ctions are of paramount importance. Among all viral infections, herpes viruses (herpes simplex virus, varicella zoster virus, Epstein-Barr virus, cyto...
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Randula Ranawaka Kavinda Dayasiri Erandima Sandamali Manoji Gamage Source Type: research
The effects of urolithin A on poly I:C-induced microglial activation
Front Cell Neurosci. 2024 Mar 20;18:1343562. doi: 10.3389/fncel.2024.1343562. eCollection 2024.ABSTRACTNeuroinflammation can be triggered by various stimuli, including viral infections. Viruses can directly invade the brain and infect neuronal cells or indirectly trigger a "cytokine storm" in the periphery that eventually leads to microglial activation in the brain. While this initial activation of microglial cells is important for viral clearance, chronic activation leads to excessive inflammation and oxidative stress, which can be neurotoxic. Remarkebly, recent studies have shown that certain viruses such as influenza A ...
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Yakum Benard Mingo Lea Gabele Niklas Lonnemann Bert Br ône Martin Korte Shirin Hosseini Source Type: research
Resolution of metastatic neck nodes associated with a periauricular cutaneous squamous cell carcinoma after intranodal injection of talimogene laherparepvec
JAAD Case Rep. 2024 Feb 18;46:92-94. doi: 10.1016/j.jdcr.2024.02.008. eCollection 2024 Apr.NO ABSTRACTPMID:38577494 | PMC:PMC10992271 | DOI:10.1016/j.jdcr.2024.02.008 (Source: Herpes)
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Yonglu Che Curtis Chong Marketa Limova Laura Morris Sunil Arani Reddy Anne Lynn S Chang Source Type: research
Promising Potential of Curcumin and Related Compounds for Antiviral Drug Discovery
Med Chem. 2024 Apr 2. doi: 10.2174/0115734064277371240325105016. Online ahead of print.ABSTRACTViruses are acellular, microscopic, and mobile particles containing genetic particles, either DNA/RNA strands as nucleoproteins, responsible for 69,53,743 deaths till the year 2023. Curcumin and related compounds are among the areas of pivotal interest for researchers because of their versatile pharmacological profile. Chemically known as diferuloylmethane, which is a main constituent of turmeric along with demethoxycurcumin and bisdemethoxycurcumin, they have a broad spectrum of antiviral activity against viruses such as human i...
Source: Herpes - April 4, 2024 Category: Infectious Diseases Authors: Archana Sharma Twinkle Sharma Rajveer Bhaskar Monika Ola Alok Sharma Vijay Kumar Thakur Prabodh Chander Sharma Source Type: research
A Case Report of Herpes Zoster After Botulinum Toxin Injections
Int Med Case Rep J. 2024 Mar 29;17:261-263. doi: 10.2147/IMCRJ.S457239. eCollection 2024.ABSTRACTThis case report presents a rare occurrence of herpes zoster (HZ) outbreak in a 50-year-old male following botulinum toxin (BTX) type A injections. The patient developed burning swollen lesions on the left forehead four days after receiving BTX injections. Physical examination revealed papules and erosions in a dermatomal distribution. He was diagnosed with HZ and promptly treated with oral acyclovir. The lesions resolved within two weeks without complications. Previous literature reports a few similar HZ outbreaks following ae...
Source: Herpes - April 4, 2024 Category: Infectious Diseases Authors: Shadi Zari Source Type: research
Translational arrest and mRNA decay are independent activities of alphaherpesvirus virion host shutoff proteins
J Gen Virol. 2024 Apr;105(4). doi: 10.1099/jgv.0.001976.ABSTRACTThe herpes simplex virus 1 (HSV1) virion host shutoff (vhs) protein is an endoribonuclease that regulates the translational environment of the infected cell, by inducing the degradation of host mRNA via cellular exonuclease activity. To further understand the relationship between translational shutoff and mRNA decay, we have used ectopic expression to compare HSV1 vhs (vhsH) to its homologues from four other alphaherpesviruses - varicella zoster virus (vhsV), bovine herpesvirus 1 (vhsB), equine herpesvirus 1 (vhsE) and Marek's disease virus (vhsM). Only vhsH, ...
Source: Herpes - April 4, 2024 Category: Infectious Diseases Authors: Lucy Eke Alistair Tweedie Sophie Cutts Emma L Wise Gillian Elliott Source Type: research
An epidemiological examination of neonatal opioid withdrawal syndrome and maternal and infant characteristics
CONCLUSIONS: This study emphasizes the complexity of challenges facing families impacted by NOWS, the importance of multifaceted prevention, and the need to conduct HCV testing in NOWS infants.PMID:38573341 | DOI:10.1007/s00737-024-01460-2 (Source: Herpes)
Source: Herpes - April 4, 2024 Category: Infectious Diseases Authors: Ashlyn N Schwartz Laurie L Meschke Source Type: research
Risk of herpes zoster in adults with SARS-CoV-2 infection in Spain: a population-based, retrospective cohort study
CONCLUSIONS: These results support an association between SARS-CoV-2 infection and HZ, with a greater HZ risk in severe cases of SARS-CoV-2 infection.PMID:38575055 | DOI:10.1016/j.ijid.2024.107037 (Source: Herpes)
Source: Herpes - April 4, 2024 Category: Infectious Diseases Authors: Elisa Correcher-Mart ínez M ónica López-Lacort Cintia Mu ñoz-Quiles Javier D íez-Domingo Alejandro Orrico-S ánchez Source Type: research
Potent and long-lasting humoral and cellular immunity against varicella zoster virus induced by mRNA-LNP vaccine
In this study, we aimed to evaluate immunogenicity and memory response induced by three mRNA-LNP-based vaccine candidates targeting VZV's surface glycoprotein E (gE). C57BL/6 mice were immunized with each candidate vaccine, and humoral and cellular immune responses were assessed. Our results demonstrate that the mRNA-LNP-based vaccine candidates elicited robust and durable humoral responses specific to the gE antigen. Notably, mice vaccinated with the mRNA-LNP vaccines exhibited significantly higher antigen-specific T-cell cytokine production compared to the group receiving Shingrix®, the current standard of care vaccine....
Source: Herpes - April 4, 2024 Category: Infectious Diseases Authors: Anannya Bhattacharya Lonzaric Jan Olga Burlak Jilong Li Ghanshyam Upadhyay Katherine Williams Jinhui Dong Harrison Rohrer Michelle Pynn Andrew Simon Nathan Kuhlmann Sergei Pustylnikov Mariane B Melo Antu K Dey Source Type: research
Comparative analysis of microbial composition and functional characteristics in dental plaque and saliva of oral cancer patients
CONCLUSIONS: Significant differences in the microbial and genetic composition of saliva and dental plaque samples were observed in OC patients. Furthermore, pathogenic bacteria associated with oral diseases were predominantly enriched in saliva. The identification of inter-group differential biomarkers and pathways provide insights into the relationship between oral microbiota and the occurrence and development of OC.PMID:38575895 | DOI:10.1186/s12903-024-04181-1 (Source: Herpes)
Source: Herpes - April 4, 2024 Category: Infectious Diseases Authors: Man Zhang Yiming Zhao Abdulrahim Umar Hailin Zhang Lirong Yang Jing Huang Ying Long Zheng Yu Source Type: research
