Resorbable nanofibrous membranes for local and sustained co-delivery of acyclovir and ketorolac in herpes therapy
This study used electrospinning to develop biodegradable nanofibrous poly(lactic-co-glycolic acid) (PLGA) membranes for delivery of both acyclovir and ketorolac. The structure of the spun nanofibers was assessed via scanning electron microscopy (SEM), and the appearance of loaded acyclovir and ketorolac in the nanofibers was confirmed with Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Release profiles of these drugs from the nanofibrous membranes were assessed using in vitro elution studies, high-performance liquid chromatography (HPLC) assays, and in vivo drug release patterns...
Source: Herpes - March 11, 2024 Category: Infectious Diseases Authors: Shih-Jyun Shen Pin-Chao Feng Ren-Chin Wu Yi-Hua Kuo Shih-Jung Liu Hiroshi Ito Source Type: research
HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus
Cell Rep. 2024 Mar 9;43(3):113788. doi: 10.1016/j.celrep.2024.113788. Online ahead of print.ABSTRACTHistone deacetylases (HDACs) regulate gene expression and innate immunity. Previously, we showed that HDAC5 is degraded during Vaccinia virus (VACV) infection and is a restriction factor for VACV and herpes simplex virus type 1. Here, we report that HDAC5 promotes interferon regulatory factor 3 (IRF3) activation downstream of Toll-IL-1 receptor (TIR) domain-containing adaptor molecule-1 or Sendai virus-mediated stimulation without requiring HDAC activity. Loss of HDAC5-mediated IRF3 activation is restored by re-introduction ...
Source: Herpes - March 10, 2024 Category: Infectious Diseases Authors: Yongxu Lu Yiqi Zhao Chen Gao Shreehari Suresh Jinghao Men Amelia Sawyers Geoffrey L Smith Source Type: research
HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus
Cell Rep. 2024 Mar 9;43(3):113788. doi: 10.1016/j.celrep.2024.113788. Online ahead of print.ABSTRACTHistone deacetylases (HDACs) regulate gene expression and innate immunity. Previously, we showed that HDAC5 is degraded during Vaccinia virus (VACV) infection and is a restriction factor for VACV and herpes simplex virus type 1. Here, we report that HDAC5 promotes interferon regulatory factor 3 (IRF3) activation downstream of Toll-IL-1 receptor (TIR) domain-containing adaptor molecule-1 or Sendai virus-mediated stimulation without requiring HDAC activity. Loss of HDAC5-mediated IRF3 activation is restored by re-introduction ...
Source: Herpes - March 10, 2024 Category: Infectious Diseases Authors: Yongxu Lu Yiqi Zhao Chen Gao Shreehari Suresh Jinghao Men Amelia Sawyers Geoffrey L Smith Source Type: research
Hospitalisation for herpes zoster in people with and without diabetes: A 10-year-observational study
CONCLUSIONS: Diabetes markedly increases HZ hospitalization rates, rehospitalization, and complication risks. These findings underscore the need for preventive strategies, especially improved glycemic control among high-risk diabetic patients, to inform public health policies and clinical practices aimed at mitigating HZ's impact on this population.PMID:38460790 | DOI:10.1016/j.diabres.2024.111603 (Source: Herpes)
Source: Herpes - March 9, 2024 Category: Infectious Diseases Authors: Carlo B Giorda Roberta Picariello Barbara Tartaglino Elisa Nada Francesco Romeo Giuseppe Costa Roberto Gnavi Source Type: research
Clinical and demographic profile of herpes zoster ophthalmicus: A hospital-based study of 1752 Indian patients
CONCLUSION: HZO more commonly affects males in the seventh decade of life and is predominantly unilateral. It more commonly affects those from higher socioeconomic strata and metropolitan regions. Half of the eyes have mild or no visual impairment, while others have moderate to severe impairment. Institution of antivirals within 72 h is associated with less severe involvement. Surgical intervention is warranted in a tenth of the eyes.PMID:38454843 | DOI:10.4103/IJO.IJO_2634_23 (Source: Herpes)
Source: Herpes - March 8, 2024 Category: Infectious Diseases Authors: Anubha Rathi Anthony V Das Muralidhar Ramappa Source Type: research
Interferon autoantibodies as signals of a sick thymus
Front Immunol. 2024 Feb 22;15:1327784. doi: 10.3389/fimmu.2024.1327784. eCollection 2024.ABSTRACTType I interferons (IFN-I) are key immune messenger molecules that play an important role in viral defense. They act as a bridge between microbe sensing, immune function magnitude, and adaptive immunity to fight infections, and they must therefore be tightly regulated. It has become increasingly evident that thymic irregularities and mutations in immune genes affecting thymic tolerance can lead to the production of IFN-I autoantibodies (autoAbs). Whether these biomarkers affect the immune system or tissue integrity of the host ...
Source: Herpes - March 8, 2024 Category: Infectious Diseases Authors: Bergithe E Oftedal Thea Sj øgren Anette S B Wolff Source Type: research
Organotypic model of the gingiva for studying bacterial and viral pathogens implicated in periodontitis
CONCLUSIONS: Presented OTG model constitutes a simple and convenient tool to study the interaction between bacterial and viral pathogens within the gingival tissue, including penetration, persistence and biofilm formation. It is also suitable to examine the efficiency of antimicrobial drugs.PMID:38456121 | PMC:PMC10919308 | DOI:10.1080/20002297.2023.2292382 (Source: Herpes)
Source: Herpes - March 8, 2024 Category: Infectious Diseases Authors: Anna Golda Anna Gasiorek Ewelina Dobosz Zuzanna Oruba Richard J Lamont Jan Potempa Joanna Koziel Source Type: research
Silver Coordination Polymers Driven by Adamantoid Blocks for Advanced Antiviral and Antibacterial Biomaterials
This study describes the assembly and full characterization of two new bioactive silver(I) coordination polymers (CPs) formulated as [Ag(aca)(μ-PTA)]n·5nH2O (1) and [Ag2(μ-ada)(μ3-PTA)2]n·4nH2O (2). These products were generated by exploiting a heteroleptic approach based on the use of two different adamantoid building blocks, namely 1,3,5-triaza-7-phosphaadamantane (PTA) and 1-adamantanecarboxylic (Haca) or 1,3-adamantanedicarboxylic (H2ada) acids, resulting in the assembly of 1D (1) and 3D (2). Antiviral, antibacterial, and antifungal properties of the obtained compounds were investigated in detail, followed by thei...
Source: Herpes - March 8, 2024 Category: Infectious Diseases Authors: Sabina W Jaros Magdalena Florek Barbara Ba żanów Jaros ław Panek Agnieszka Krogul-Sobczak M Concei ção Oliveira Jaros ław Król Urszula Śliwińska-Hill Dmytro S Nesterov Alexander M Kirillov Piotr Smole ński Source Type: research
Four new resin glycosides from Ipomoea muricata seeds: muricatins XIV-XVII
J Nat Med. 2024 Mar 8. doi: 10.1007/s11418-024-01787-1. Online ahead of print.ABSTRACTIpomoea muricata (L.) Jacq. seeds (Convolvulaceae) are used as a traditional laxative and carminative medicine. Muricatins XIV (1), XV (2), XVI (3), and XVII (4), were isolated from I. muricata seeds as four new resin glycosides, along with seven known compounds, three of which were isolated for the first time as natural products; their structures were determined using MS and NMR spectroscopy. Compounds 1-4 are macrolactones (jalapins); the sugar moieties of 1, 2, and 4 are partially acylated with 2S-methylbutyric acid, while that of 3 is...
Source: Herpes - March 8, 2024 Category: Infectious Diseases Authors: Masateru Ono Daiki Tenmaya Maki Tarumi Syouri Satou Kotone Tsuji Hirotaka Nishikawa Shin Yasuda Hiroyuki Miyashita Jian-Rong Zhou Kazumi Yokomizo Hitoshi Yoshimitsu Ryota Tsuchihashi Masafumi Okawa Junei Kinjo Source Type: research
Neonatal herpes simplex virus encephalitis with intracranial bleeding in a newborn baby with concurrent rhesus incompatibility
We report a baby with neonatal herpes simplex virus (HSV) encephalitis concurrent with Rrhesus (Rh) incompatibility. He was delivered by a Ggravida 2 mother with a history of miscarriage in her previous pregnancy at a gestation age of 4 months. She had Bblood group 0 and Rrhesus negative. The baby was noticed to have jaundice on day one1 of life accompanied by generalised petechiae on the face and upper chest. A full blood picture revealed severe anaemia and severe thrombocytopaenia and HSV 1/2 IgM was positive. MRI of the brain showed multiple extensive haemorrhagic lesions on the frontal-temporal regions.PMID:38458763 | ...
Source: Herpes - March 8, 2024 Category: Infectious Diseases Authors: Pascal Clemence Haika Mariki Martha Mkony Karim Premji Manji Source Type: research
Clinical and demographic profile of herpes zoster ophthalmicus: A hospital-based study of 1752 Indian patients
CONCLUSION: HZO more commonly affects males in the seventh decade of life and is predominantly unilateral. It more commonly affects those from higher socioeconomic strata and metropolitan regions. Half of the eyes have mild or no visual impairment, while others have moderate to severe impairment. Institution of antivirals within 72 h is associated with less severe involvement. Surgical intervention is warranted in a tenth of the eyes.PMID:38454843 | DOI:10.4103/IJO.IJO_2634_23 (Source: Herpes)
Source: Herpes - March 8, 2024 Category: Infectious Diseases Authors: Anubha Rathi Anthony V Das Muralidhar Ramappa Source Type: research
Interferon autoantibodies as signals of a sick thymus
Front Immunol. 2024 Feb 22;15:1327784. doi: 10.3389/fimmu.2024.1327784. eCollection 2024.ABSTRACTType I interferons (IFN-I) are key immune messenger molecules that play an important role in viral defense. They act as a bridge between microbe sensing, immune function magnitude, and adaptive immunity to fight infections, and they must therefore be tightly regulated. It has become increasingly evident that thymic irregularities and mutations in immune genes affecting thymic tolerance can lead to the production of IFN-I autoantibodies (autoAbs). Whether these biomarkers affect the immune system or tissue integrity of the host ...
Source: Herpes - March 8, 2024 Category: Infectious Diseases Authors: Bergithe E Oftedal Thea Sj øgren Anette S B Wolff Source Type: research
Organotypic model of the gingiva for studying bacterial and viral pathogens implicated in periodontitis
CONCLUSIONS: Presented OTG model constitutes a simple and convenient tool to study the interaction between bacterial and viral pathogens within the gingival tissue, including penetration, persistence and biofilm formation. It is also suitable to examine the efficiency of antimicrobial drugs.PMID:38456121 | PMC:PMC10919308 | DOI:10.1080/20002297.2023.2292382 (Source: Herpes)
Source: Herpes - March 8, 2024 Category: Infectious Diseases Authors: Anna Golda Anna Gasiorek Ewelina Dobosz Zuzanna Oruba Richard J Lamont Jan Potempa Joanna Koziel Source Type: research
Silver Coordination Polymers Driven by Adamantoid Blocks for Advanced Antiviral and Antibacterial Biomaterials
This study describes the assembly and full characterization of two new bioactive silver(I) coordination polymers (CPs) formulated as [Ag(aca)(μ-PTA)]n·5nH2O (1) and [Ag2(μ-ada)(μ3-PTA)2]n·4nH2O (2). These products were generated by exploiting a heteroleptic approach based on the use of two different adamantoid building blocks, namely 1,3,5-triaza-7-phosphaadamantane (PTA) and 1-adamantanecarboxylic (Haca) or 1,3-adamantanedicarboxylic (H2ada) acids, resulting in the assembly of 1D (1) and 3D (2). Antiviral, antibacterial, and antifungal properties of the obtained compounds were investigated in detail, followed by thei...
Source: Herpes - March 8, 2024 Category: Infectious Diseases Authors: Sabina W Jaros Magdalena Florek Barbara Ba żanów Jaros ław Panek Agnieszka Krogul-Sobczak M Concei ção Oliveira Jaros ław Król Urszula Śliwińska-Hill Dmytro S Nesterov Alexander M Kirillov Piotr Smole ński Source Type: research
Four new resin glycosides from Ipomoea muricata seeds: muricatins XIV-XVII
J Nat Med. 2024 Mar 8. doi: 10.1007/s11418-024-01787-1. Online ahead of print.ABSTRACTIpomoea muricata (L.) Jacq. seeds (Convolvulaceae) are used as a traditional laxative and carminative medicine. Muricatins XIV (1), XV (2), XVI (3), and XVII (4), were isolated from I. muricata seeds as four new resin glycosides, along with seven known compounds, three of which were isolated for the first time as natural products; their structures were determined using MS and NMR spectroscopy. Compounds 1-4 are macrolactones (jalapins); the sugar moieties of 1, 2, and 4 are partially acylated with 2S-methylbutyric acid, while that of 3 is...
Source: Herpes - March 8, 2024 Category: Infectious Diseases Authors: Masateru Ono Daiki Tenmaya Maki Tarumi Syouri Satou Kotone Tsuji Hirotaka Nishikawa Shin Yasuda Hiroyuki Miyashita Jian-Rong Zhou Kazumi Yokomizo Hitoshi Yoshimitsu Ryota Tsuchihashi Masafumi Okawa Junei Kinjo Source Type: research
