Therapeutic targeting at genome mutations of liver cancer by the insertion of HSV1 thymidine kinase through Cas9-mediated editing
CONCLUSIONS: Our studies suggested that mutation targeting may hold promise as a versatile and effective approach to treating liver cancers.PMID:38497929 | PMC:PMC10948134 | DOI:10.1097/HC9.0000000000000412 (Source: Herpes)
Source: Herpes - March 18, 2024 Category: Infectious Diseases Authors: Muhamuda Kader Wei Sun Bao-Guo Ren Yan-Ping Yu Junyan Tao Lesley M Foley Silvia Liu Satdarshan P Monga Jian-Hua Luo Source Type: research
Long-term Efficacy and Safety Following Switch Between Upadacitinib and Adalimumab in Patients with Rheumatoid Arthritis: 5-Year Data from SELECT-COMPARE
CONCLUSION: Switching to a different MoA may provide long-term benefit to patients with RA not achieving treatment goals with their initial therapy, with acceptable safety profiles.TRIAL REGISTRATION: NCT02629159.PMID:38498140 | DOI:10.1007/s40744-024-00658-1 (Source: Herpes)
Source: Herpes - March 18, 2024 Category: Infectious Diseases Authors: Roy Fleischmann Ricardo Blanco Filip Van den Bosch Louis Bessette Yanna Song Sara K Penn Erin McDearmon-Blondell Nasser Khan Kelly Chan Eduardo Mysler Source Type: research
Education to improve timeliness of shingles diagnosis: Cluster RCT and qualitative study
CONCLUSION: Our educational intervention did not improve the timely assessment of patients with shingles. This may be the result of poor intervention engagement.PMID:38499295 | DOI:10.3399/BJGP.2023.0477 (Source: Herpes)
Source: Herpes - March 18, 2024 Category: Infectious Diseases Authors: Elizabeth Lovegrove Stephanie J MacNeill Yumeng Liu Sophie Rees Jonathan Banks Robert Johnson Matthew J Ridd Source Type: research
A high-throughput DNA analysis method based on isothermal amplification on a suspension microarray for detecting mpox virus and viruses with comparable symptoms
In this study, we combined suspension microarray technology with recombinase-aided amplification technology (RAA) to establish a high-throughput, sensitive, and quantitative method for detecting MPXV and other viruses that can cause similar symptoms. The experimental results confirmed that the technique has outstanding sensitivity, with a minimum detection limit (LOD) of 0.1 fM and a linear range of 0.3 fM to 20 pM, spanning five orders of magnitude. The approach also exhibits exquisite selectivity, as the amplified signal can only be detected when the target virus nucleic acid is present. Additionally, serum recoveries ra...
Source: Herpes - March 18, 2024 Category: Infectious Diseases Authors: Liming Zhang Jieyu Liu Shisi Huang Wentao Zeng Li Li Xihao Fan Zhuoxuan Lu Source Type: research
Modelling the Public Health Burden of Herpes Zoster and the Impact of Adjuvanted Recombinant Zoster Vaccine in Five Selected Countries in Southeast Asia
CONCLUSIONS: This study demonstrated that there is substantial HZ disease burden in older adults for the five selected countries in Southeast Asia, negatively impacting national healthcare systems. Introducing RZV could potentially reduce this burden. A graphical abstract is available with this article.PMID:38493411 | DOI:10.1007/s40121-024-00945-y (Source: Herpes)
Source: Herpes - March 17, 2024 Category: Infectious Diseases Authors: Ru Han Peter San Martin Nurilign Ahmed Adriana Guzman-Holst Ahmed Mohy Thatiana Pinto Bruna de Veras Jorge A Gomez Gyneth Lourdes Bibera D ésirée A M van Oorschot Source Type: research
Movement disorders associated with pediatric encephalitis
Handb Clin Neurol. 2024;200:229-238. doi: 10.1016/B978-0-12-823912-4.00018-9.ABSTRACTNew onset movement disorders are a common clinical problem in pediatric neurology and can be infectious, inflammatory, metabolic, or functional in origin. Encephalitis is one of the more important causes of new onset movement disorders, and movement disorders are a common feature (~25%) of all encephalitis. However, all encephalitides are not the same, and movement disorders are a key diagnostic feature that can help the clinician identify the etiology of the encephalitis, and therefore appropriate treatment is required. Movement disorders...
Source: Herpes - March 17, 2024 Category: Infectious Diseases Authors: Russell C Dale Shekeeb S Mohammad Source Type: research
Modelling the Public Health Burden of Herpes Zoster and the Impact of Adjuvanted Recombinant Zoster Vaccine in Five Selected Countries in Southeast Asia
CONCLUSIONS: This study demonstrated that there is substantial HZ disease burden in older adults for the five selected countries in Southeast Asia, negatively impacting national healthcare systems. Introducing RZV could potentially reduce this burden. A graphical abstract is available with this article.PMID:38493411 | DOI:10.1007/s40121-024-00945-y (Source: Herpes)
Source: Herpes - March 17, 2024 Category: Infectious Diseases Authors: Ru Han Peter San Martin Nurilign Ahmed Adriana Guzman-Holst Ahmed Mohy Thatiana Pinto Bruna de Veras Jorge A Gomez Gyneth Lourdes Bibera D ésirée A M van Oorschot Source Type: research
Movement disorders associated with pediatric encephalitis
Handb Clin Neurol. 2024;200:229-238. doi: 10.1016/B978-0-12-823912-4.00018-9.ABSTRACTNew onset movement disorders are a common clinical problem in pediatric neurology and can be infectious, inflammatory, metabolic, or functional in origin. Encephalitis is one of the more important causes of new onset movement disorders, and movement disorders are a common feature (~25%) of all encephalitis. However, all encephalitides are not the same, and movement disorders are a key diagnostic feature that can help the clinician identify the etiology of the encephalitis, and therefore appropriate treatment is required. Movement disorders...
Source: Herpes - March 17, 2024 Category: Infectious Diseases Authors: Russell C Dale Shekeeb S Mohammad Source Type: research
Characteristics of reproductive tract infections caused by common pathogens among the outpatients of reproductive medicine center in Putian: retrospective study
CONCLUSIONS: This study showed that UU was the most frequently identified pathogen in infertile men in Putian, Fujian Province. The CT infection rate was the highest in people under 20 years old, and the infection showed a tendency toward young individuals. Therefore, the publicity of sexual health knowledge must be strengthened, and the prevention and treatment of venereal diseases among young and middle-aged people must be improved. Moreover, the pathogen infection is related to infertility to a certain extent, which is conducive to clinical diagnosis and treatment.PMID:38486167 | PMC:PMC10941379 | DOI:10.1186/s12879-024...
Source: Herpes - March 15, 2024 Category: Infectious Diseases Authors: Jiancheng Zeng Tingli Wu Laiping Wang Liumin Yu Hua Lin Zhanfei Chen Source Type: research
Development and evaluation of a time-resolved fluorescence labelled immunochromatographic strip assay for rapid and quantitative detection of bovine herpesvirus 1
Front Microbiol. 2024 Feb 29;15:1371849. doi: 10.3389/fmicb.2024.1371849. eCollection 2024.ABSTRACTBovine herpes virus 1 (BoHV-1) causes a wide variety of diseases in wild and domestic cattle. The most widely used method for viral identification is real-time PCR, which can only be performed in laboratories using sophisticated instruments by expert personnel. Herein, we developed an ultrasensitive time-resolved fluorescence lateral flow immunochromatographic strip (ICS) assay for detecting BoHV-1 in bovine samples using a monoclonal antibody against BoHV-1 labelled with fluorescent microspheres, which can be applied in any ...
Source: Herpes - March 15, 2024 Category: Infectious Diseases Authors: Wenxiao Liu Kun Zhang Jing Cheng Shiqiang Yu Chunjie Cheng Bo Jiang Linyi Zhou Yongqing Li Source Type: research
Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo
Acta Pharm Sin B. 2024 Mar;14(3):1362-1379. doi: 10.1016/j.apsb.2023.10.004. Epub 2023 Oct 13.ABSTRACTExtracellular vesicles (EVs) have recently emerged as a promising delivery platform for CRISPR/Cas9 ribonucleoproteins (RNPs), owing to their ability to minimize off-target effects and immune responses. However, enhancements are required to boost the efficiency and safety of Cas9 RNP enrichment within EVs. In response, we employed the Fc/Spa interaction system, in which the human Fc domain was fused to the intracellular domain of PTGFRN-Δ687 and anchored to the EV membrane. Simultaneously, the B domain of the Spa protein ...
Source: Herpes - March 15, 2024 Category: Infectious Diseases Authors: Yuanda Wan Liren Li Ruilin Chen Jiajia Han Qiyun Lei Zhipeng Chen Xiaodong Tang Wenyu Wu Shuwen Liu Xingang Yao Source Type: research
Trigeminal Neuralgia Secondary to Herpes Simplex Virus Type 1 Infection Treated With Oral Acyclovir
We report the case of a 30-year-old woman who developed oral HSV-1 lesions followed by right-sided TN pain. MRI of the brain did not reveal neurovascular compression. TN pain completely resolved with oral acyclovir treatment alone, without anticonvulsants. This highlights the importance of considering atypical etiologies such as HSV-1 reactivation in TN evaluation. Early antiviral therapy may treat underlying inflammation and provide sustained symptom relief in HSV-associated TN.PMID:38487110 | PMC:PMC10939157 | DOI:10.7759/cureus.54128 (Source: Herpes)
Source: Herpes - March 15, 2024 Category: Infectious Diseases Authors: Amal J Alfaifi Ohood S Wasli Thamer M Almalki Ahmad Y Alqassim Source Type: research
Periorbital necrotizing sweet syndrome: A report of two cases mimicking necrotizing soft tissue infections
CONCLUSION: nSS is rare and a high level of clinical suspicion as well as an understanding of its distinguishing features is necessary to avoid undue morbidity. Identification of pathergy, histopathology, microbiology, and clinical context are critical to avoid misdiagnosis of infection.PMID:38487334 | PMC:PMC10937104 | DOI:10.1016/j.ajoc.2024.102033 (Source: Herpes)
Source: Herpes - March 15, 2024 Category: Infectious Diseases Authors: Hursuong Vongsachang Carolina A Chiou Amee D Azad Lisa Y Lin Michael K Yoon Daniel R Lefebvre Anna M Stagner Source Type: research
Real-world effectiveness of recombinant zoster vaccine in self-identified Chinese individuals aged ≥50 years in the United States
Hum Vaccin Immunother. 2024 Dec 31;20(1):2327145. doi: 10.1080/21645515.2024.2327145. Epub 2024 Mar 15.ABSTRACTWe evaluated the vaccine effectiveness (VE) of two doses of recombinant zoster vaccine (RZV) against herpes zoster (HZ) and postherpetic neuralgia (PHN) in Chinese adults at Kaiser Permanente Southern California (KPSC). Chinese KPSC members were identified based on self-reported ethnicity or self-reported preferred spoken/written language. Those aged ≥50 years who received two doses of RZV 4 weeks to ≤ 6 months apart were matched 1:4 to RZV unvaccinated Chinese members and followed through June 2022; second do...
Source: Herpes - March 15, 2024 Category: Infectious Diseases Authors: Ana Florea Lina Sy Lei Qian Bradley Ackerson Yi Luo Jun Wu Yanjun Cheng Jennifer Ku Leticia Vega Daily Harpreet Takhar Jeannie Song Elizabeth Chmielewski-Yee O'Mareen Spence Harry Seifert Driss Oraichi Hung Fu Tseng Source Type: research
Herpes zoster infection in pregnancy: features and consequences
Arch Dermatol Res. 2024 Mar 15;316(4):107. doi: 10.1007/s00403-024-02842-3.ABSTRACTHerpes (varicella) zoster (HZ) infection occurs in 4 people per 1000 in the general US population (irrespective of prior varicella infection and vaccination status) each year and has been the subject of scientific inquiry for decades. The consequences of infection are myriad and may depend on the dermatome of involvement as well as host factors such as age, comorbidities, prior treatment or immunization, and immunologic status. Pregnancy is associated with an altered immune and hormonal status in the mother. While maternal HZ infection durin...
Source: Herpes - March 15, 2024 Category: Infectious Diseases Authors: Amit Singal Robert A Schwartz Chinmoy Bhate Source Type: research
