Downregulation of endogenous nectin1 in human keratinocytes by herpes simplex virus 1 glycoprotein D excludes superinfection but does not affect NK cell function
J Gen Virol. 2024 Mar;105(3). doi: 10.1099/jgv.0.001969.ABSTRACTMany viruses downregulate their cognate receptors, facilitating virus replication and pathogenesis via processes that are not yet fully understood. In the case of herpes simplex virus 1 (HSV1), the receptor binding protein glycoprotein D (gD) has been implicated in downregulation of its receptor nectin1, but current understanding of the process is limited. Some studies suggest that gD on the incoming virion is sufficient to achieve nectin1 downregulation, but the virus-encoded E3 ubiquitin ligase ICP0 has also been implicated. Here we have used the physiologic...
Source: Herpes - March 12, 2024 Category: Infectious Diseases Authors: Joanne Kite Monica Hill Natasha Preston Anzelika Rubina Simon Kollnberger Eddie Chung Yern Wang Gillian Elliott Source Type: research
Hospitalization and Mortality in Patients With Darier Disease Complicated by Kaposi Varicelliform Eruption: A Systematic Review
J Cutan Med Surg. 2024 Mar 11:12034754241239273. doi: 10.1177/12034754241239273. Online ahead of print.NO ABSTRACTPMID:38468195 | DOI:10.1177/12034754241239273 (Source: Herpes)
Source: Herpes - March 12, 2024 Category: Infectious Diseases Authors: Iryna Savinova Nawar Tarafdar Muskaan Sachdeva Abrahim Abduelmula Khalad Maliyar Jorge R Georgakopoulos Asfandyar Mufti Jensen Yeung Source Type: research
Efficacy and safety of low-dose corticosteroids combined with leflunomide for progressive IgA nephropathy: a systematic review and meta-analysis
CONCLUSIONS: Low-dose corticosteroids combined with leflunomide are a safe and effective treatment for progressive IgA nephropathy.TRIAL REGISTRATION: The PROSPERO registration number is CRD42022361883.PMID:38468247 | DOI:10.1186/s12894-024-01438-3 (Source: Herpes)
Source: Herpes - March 12, 2024 Category: Infectious Diseases Authors: Dongxu Zhang Bowen Xia Xin Zhang Pu Liang Xiaopeng Hu Source Type: research
Effects of pubic hair grooming on women's sexual health: a systematic review and meta-analysis
CONCLUSION: This review aligns with previous observational studies regarding sexual health outcomes of pubic hair grooming. There is a need to raise awareness among women regarding the safe practice of pubic hair grooming, emphasizing the clarification of hazards and benefits.PMID:38468306 | DOI:10.1186/s12905-024-02951-1 (Source: Herpes)
Source: Herpes - March 12, 2024 Category: Infectious Diseases Authors: Asmaa Eltobgy Ahmed Aljabali Ahmed Farag Mohammad Elshorbgy Mona Hamed Esraa Hamouda Heba Hamouda Neveen Refaey Marwa Kabeel Sarah Amro Toka Abouheseba Mohammed Tarek Source Type: research
Beyond the First Year: Epidemiology and Management of Late-Onset Opportunistic Infections After Kidney Transplantation
Transpl Int. 2024 Feb 26;37:12065. doi: 10.3389/ti.2024.12065. eCollection 2024.ABSTRACTLate opportunistic infections (OI) occurring beyond the first year after kidney transplantation (KT) are poorly described and not targeted by prophylactic strategies. We performed a ten-year retrospective monocentric cohort study describing epidemiology, risk factors and impact of late OI occurring 1 year after KT. We included clinically symptomatic OI requiring treatment besides BK virus nephropathy. Control groups included early OI occurring in the first year after KT, and KT recipients without OI since KT and alive with a functional ...
Source: Herpes - March 12, 2024 Category: Infectious Diseases Authors: V Esnault L Hoisnard B Peiffer V Fihman S Fourati C Angebault C Champy S Gallien P Attias A Morel P Grimbert G Melica M Matignon Source Type: research
Vesicular herpes zoster eruption following chronic obstructive pulmonary disease treatment in the emergency department: lessons learnt from immunosuppression
CONCLUSION: HZ can develop in COPD patients, mainly using inhaled steroids. Compliance to medication should be monitored, on the other hand zoster vaccination should be provided to prevent it and its foremost complication which includes secondary bacterial infection, post-herpetic neuralgia, scarring, nerve palsy and encephalitis in case with disseminated zoster.PMID:38463104 | PMC:PMC10923375 | DOI:10.1097/MS9.0000000000001698 (Source: Herpes)
Source: Herpes - March 11, 2024 Category: Infectious Diseases Authors: Abhigan Babu Shrestha Pukar Gupta Nisha Gurung Sudarshan Kandel Mahima Upadhyay Amrita Gurung Shailendra Karki Mobin Ibne Mokbul Source Type: research
Trabectedin Enhances Oncolytic Virotherapy by Reducing Barriers to Virus Spread and Cytotoxic Immunity in Preclinical Pediatric Bone Sarcoma
bioRxiv [Preprint]. 2024 Mar 3:2024.03.02.582994. doi: 10.1101/2024.03.02.582994.ABSTRACTWe previously reported that the DNA alkylator and transcriptional-blocking chemotherapeutic agent trabectedin enhances oncolytic herpes simplex viroimmunotherapy in human sarcoma xenograft models, though the mechanism remained to be elucidated. Here we report trabectedin disrupts the intrinsic cellular anti-viral response which increases viral transcript spread throughout the human tumor cells. We also extended our synergy findings to syngeneic murine sarcoma models, which are poorly susceptible to virus infection. In the absence of ro...
Source: Herpes - March 11, 2024 Category: Infectious Diseases Authors: Emily M Ringwalt Mark A Currier Andrea M Glaspell Chun-Yu Chen Matthew V Cannon Maren Cam Amy C Gross Matthew Gust Pin-Yi Wang Louis Boon Laura E Biederman Emily Schwarz Prajwal Rajappa Dean A Lee Elaine R Mardis William E Carson Ryan D Roberts Timothy P Source Type: research
Janus kinase inhibitors in atopic dermatitis: an umbrella review of meta-analyses
CONCLUSION: Compared to placebo or dupilumab, the administration of JKIs can ameliorate IGA response more effectively, improve the EASI75, and relieve pruritus without severe adverse effect, while accompanied by more acne, nasopharyngitis, headache, and digestive disturbances. The curative effect of 200 mg of abrocitinib is significant and more caution should be given in patients with gastrointestinal dysfunction, herpes zoster, and those who are acne-prone. Baricitinib and upadacitinib should be avoided in populations at high risk for cardiovascular events.SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prosper...
Source: Herpes - March 11, 2024 Category: Infectious Diseases Authors: Qingying He Xin Xie Qian Chen Wenquan Li Zongzhou Song Xurui Wang Xiao Ma Jinhao Zeng Jing Guo Source Type: research
Targeting latent viral infection in EBV-associated lymphomas
Front Immunol. 2024 Feb 23;15:1342455. doi: 10.3389/fimmu.2024.1342455. eCollection 2024.ABSTRACTEpstein-Barr virus (EBV) contributes to the development of a significant subset of human lymphomas. As a herpes virus, EBV can transition between a lytic state which is required to establish infection and a latent state where a limited number of viral antigens are expressed which allows infected cells to escape immune surveillance. Three broad latency programs have been described which are defined by the expression of viral proteins RNA, with latency I being the most restrictive expressing only EBV nuclear antigen 1 (EBNA1) and...
Source: Herpes - March 11, 2024 Category: Infectious Diseases Authors: Isabella Y Kong Lisa Giulino-Roth Source Type: research
Investigation into the safety, and serological responses elicited by delivery of live intranasal vaccines for bovine herpes virus type 1, bovine respiratory syncytial virus, and parainfluenza type 3 in pre-weaned calves
The objective of this study was to use a cohort of 40 dairy and dairy-beef female and male calves (27 females and 13 males) to determine serological responses to concurrent administration at 3 weeks of age (22 ± 4.85 days) of two commercially available intranasal (IN) vaccines for the viruses: bovine respiratory syncytial virus (BRSV), bovine herpes virus 1 (BoHV-1), and parainfluenza-3-virus (PI3-V). The study groups were as follows: (i) Bovilis IBR Marker Live only® (IO), (ii) Bovilis INtranasal RSP Live® only (RPO), (iii) Concurrent vaccination with Bovilis IBR Marker Live® & Bovilis Intranasal RSP Live® (CV), ...
Source: Herpes - March 11, 2024 Category: Infectious Diseases Authors: Anna Flynn Catherine McAloon Katie Sugrue Ricki Fitzgerald Cara Sheridan Bosco Cowley Conor McAloon Emer Kennedy Source Type: research
Postoperative abdominal herpes zoster complicated by intestinal obstruction: A case report
CONCLUSION: Pseudo-intestinal obstruction secondary to herpes zoster infection is difficult to distinguish from mechanical intestinal obstruction owing to various causes. In cases of inexplicable intestinal obstructions, considering the possibility of a viral infection is essential to minimize misdiagnosis and missed diagnoses.PMID:38464934 | PMC:PMC10921300 | DOI:10.12998/wjcc.v12.i6.1138 (Source: Herpes)
Source: Herpes - March 11, 2024 Category: Infectious Diseases Authors: Zhen-Yu Dong Rui-Xian Shi Xiao-Biao Song Ming-Yue Du Ji-Jun Wang Source Type: research
Sporadic Kaposi Sarcoma Following a COVID-19 Vaccine: Mere Coincidence or Something More?
Cureus. 2024 Feb 9;16(2):e53925. doi: 10.7759/cureus.53925. eCollection 2024 Feb.ABSTRACTIn this case report, we present a distinctive occurrence of classic Kaposi sarcoma (KS) in an individual of Latin origin, emerging seven days following the administration of the third dose of the ChAdOx1 nCoV-19 (AstraZeneca) vaccine. The progression of KS continued over two months, culminating in the development of a tumor. Given the absence of prior reports on KS development post-COVID-19 vaccination, the primary aim of this report is to explore the potential relationship between the ChAdOx1 nCoV-19 vaccine, reactivation of Kaposi sa...
Source: Herpes - March 11, 2024 Category: Infectious Diseases Authors: Jes ús Iván Martínez-Ortega Arely Gissell Ramirez Cibrian Elvis Martinez-Jaramillo Maria Del Consuelo Garc ía Silva Source Type: research
Neurosurgical treatment of postherpetic neuralgia
Zh Nevrol Psikhiatr Im S S Korsakova. 2024;124(2):154-157. doi: 10.17116/jnevro2024124021154.ABSTRACTPostherpetic neuralgia is a chronic and debilitating condition that can occur following an episode of herpes zoster (shingles). It is characterized by severe, persistent pain in the area where the shingles rash occurred. While various treatment approaches exist, including medications and non-invasive therapies, some cases of postherpetic neuralgia may require neurosurgical intervention. Neurosurgical treatment options for postherpetic neuralgia aim to alleviate the pain by targeting the affected nerves or neural pathways. O...
Source: Herpes - March 11, 2024 Category: Infectious Diseases Authors: E D Isagulyan D E Semenov A A Tomskiy Source Type: research
Exploring Heparanase Levels in Tears: Insights From Herpes Simplex Virus-1 Keratitis Patients and Animal Studies
CONCLUSIONS: To the best of our knowledge, this study is the first to report elevated HPSE levels in the tears of patients with different forms of HSV-1 keratitis, and it confirms similar findings in a murine model, providing a valuable basis for future in vivo and clinical research on HSV-1 ocular infection.PMID:38466284 | DOI:10.1167/iovs.65.3.7 (Source: Herpes)
Source: Herpes - March 11, 2024 Category: Infectious Diseases Authors: Satyashree Gagan Agimanailiu Khapuinamai Divya Kapoor Pankaj Sharma Tejabhiram Yadavalli Joveeta Joseph Deepak Shukla Bhupesh Bagga Source Type: research
Therapeutic Effect and Adverse Event Rate of Different Treatment Methods in Patients with Multiple Myeloma and Renal Insufficiency
CONCLUSION: The application of the BCD regimen in the treatment of MM has shown significant efficiency, effectively alleviating clinical symptoms with fewer adverse reactions and high safety.PMID:38467118 | DOI:10.1159/000536170 (Source: Herpes)
Source: Herpes - March 11, 2024 Category: Infectious Diseases Authors: Lijuan Cui Jing Ning Rui Yang Hainan Wang Source Type: research