Vaccines and Dementia: Part I. Non-Specific Immune Boosting with BCG: History, Ligands, and Receptors
J Alzheimers Dis. 2024 Feb 20. doi: 10.3233/JAD-231315. Online ahead of print.ABSTRACTVaccines such as Bacille Calmette-Guérin (BCG) can apparently defer dementia onset with an efficacy better than all drugs known to date, as initially reported by Gofrit et al. (PLoS One14, e0224433), now confirmed by other studies. Understanding how and why is of immense importance because it could represent a sea-change in how we manage patients with mild cognitive impairment through to dementia. Given that infection and/or inflammation are likely to contribute to the development of dementias such as Alzheimer's disease (Part II of this...
Source: Herpes - February 23, 2024 Category: Infectious Diseases Authors: Charles L Greenblatt Richard Lathe Source Type: research

Vaccines and Dementia: Part II. Efficacy of BCG and Other Vaccines Against Dementia
J Alzheimers Dis. 2024 Feb 19. doi: 10.3233/JAD-231323. Online ahead of print.ABSTRACT There is growing awareness that infections may contribute to the development of senile dementia including Alzheimer's disease (AD), and that immunopotentiation is therefore a legitimate target in the management of diseases of the elderly including AD. In Part I of this work, we provided a historical and molecular background to how vaccines, adjuvants, and their component molecules can elicit broad-spectrum protective effects against diverse agents, culminating in the development of the tuberculosis vaccine strain Bacille Calmette-Guérin...
Source: Herpes - February 23, 2024 Category: Infectious Diseases Authors: Charles L Greenblatt Richard Lathe Source Type: research

Etiology of Meningoencephalitis in children aged less than 5 years
CONCLUSION: We identified the etiological agents in 50/130 (38.5%) suspected ME cases in children less than 5 years of age, using molecular and ELISA-based diagnostic methods. The four most common pathogens detected were JEV, adenovirus, influenza virus, and dengue virus.PMID:38394398 | DOI:10.4103/ijpm.ijpm_60_23 (Source: Herpes)
Source: Herpes - February 23, 2024 Category: Infectious Diseases Authors: Vivek K Mishra Tanzeela Khan Amar Jeet Om Prakash None Chandrakanta Ashish K Srivastava Sangram Singh Neelam Pathak Amita Jain Source Type: research

An unusual Wolf's isotopic response: myelodysplastic syndrome with acute myeloid leukemia developed on the herpes zoster lesions
An Bras Dermatol. 2024 Feb 22:S0365-0596(24)00012-6. doi: 10.1016/j.abd.2023.02.011. Online ahead of print.NO ABSTRACTPMID:38395631 | DOI:10.1016/j.abd.2023.02.011 (Source: Herpes)
Source: Herpes - February 23, 2024 Category: Infectious Diseases Authors: Yu Zhu Wei Wu Source Type: research

Identification and characterisation of Gamma-herpesviruses in zoo artiodactyla
CONCLUSION: This study shows the presence of pathogenic and non-pathogenic MCFVs, as well as other γ-herpesviruses, in Artiodactyla species of conservation importance and allowed the identification of new herpesviruses in some non-adapted species.PMID:38395934 | PMC:PMC10893651 | DOI:10.1186/s12985-024-02311-3 (Source: Herpes)
Source: Herpes - February 23, 2024 Category: Infectious Diseases Authors: Laura Bianchessi Edmund Flach Giulia Monacchia Mark Dagleish Madeleine Maley Lauretta Turin Mara Silvia Rocchi Source Type: research

Herpes-Zoster-Impfung auch nach Jahren effektiv
MMW Fortschr Med. 2024 Feb;166(3):23. doi: 10.1007/s15006-024-3646-4.NO ABSTRACTPMID:38388997 | DOI:10.1007/s15006-024-3646-4 (Source: Herpes)
Source: Herpes - February 23, 2024 Category: Infectious Diseases Authors: Nicola Zink Source Type: research

Anti-Herpes Simplex Virus and Anti-Inflammatory Activities of the Melittin Peptides Derived from Apis mellifera and Apis florea Venom
In this study, the effects of the melittin peptides from A. mellifera (MEL-AM) and A. florea (MEL-AF) against HSV-1 and HSV-2 were evaluated at different stages during the viral multiplication cycle in an attempt to define the mode of antiviral action using plaque reduction and virucidal assays. The results revealed a new finding that melittin at 5 µg/mL demonstrated the highest inhibitory effect on HSV through the direct inactivation of viral particles, and MEL-AF displayed a greater virucidal activity. Moreover, melittin was also observed to interfere with the process of HSV attachment to the host cells. MEL-AM exhibite...
Source: Herpes - February 23, 2024 Category: Infectious Diseases Authors: Pichet Praphawilai Thida Kaewkod Sureeporn Suriyaprom Aussara Panya Terd Disayathanoowat Yingmanee Tragoolpua Source Type: research

Association between Bell's Palsy and Cardiometabolic Risks: An Age- and Sex-Matched Case-Control Study
CONCLUSION: Screening and monitoring for CMRs, especially hyperglycemia, in every patient presenting with Bell's palsy is essential despite initial normoglycemia, particularly in older-onset cases.PMID:38392630 | DOI:10.3390/jpm14020197 (Source: Herpes)
Source: Herpes - February 23, 2024 Category: Infectious Diseases Authors: Panitta Mueanchoo Nualsakol Tepparak Pensri Chongphattararot Nannapat Pruphetkaew Suwanna Setthawatcharawanich Pat Korathanakhun Thanyalak Amornpojnimman Chutarat Sathirapanya Pornchai Sathirapanya Source Type: research

Unusual Localization of AIDS-Related Kaposi's Sarcoma in a Heterosexual Male during the COVID-19 Pandemic: A Case Report
We present a case of a 30-year-old Caucasian male with an 18-year history of HIV infection. The patient was presented with a one-week history of fever, non-productive cough, and skin lesions. There was an associated weakness and weight loss in a duration of 6 months. Clinical examination showed fever, generalized lymphadenopathy, lower limb edema, ascites, and violaceous cutaneous eruption comprising patches, plaques, and nodules. He also had a red nodule on the left conjunctiva, as well as on his oral mucosa. His CD4+ count was below 10/mm3 and ARN-HIV viral load was above 100,000 c/mL, in relation to the antiretroviral f...
Source: Herpes - February 23, 2024 Category: Infectious Diseases Authors: Manuela Arbune Monica-Daniela Padurariu-Covit Carmen Tiutiuca Raul Mihailov Elena Niculet Anca-Adriana Arbune Alin-Laurentiu Tatu Source Type: research

Atypical Neuroimaging Features of Herpes Simplex Virus-2 Encephalitis
Indian J Pediatr. 2024 Feb 23. doi: 10.1007/s12098-024-05082-5. Online ahead of print.NO ABSTRACTPMID:38393639 | DOI:10.1007/s12098-024-05082-5 (Source: Herpes)
Source: Herpes - February 23, 2024 Category: Infectious Diseases Authors: Ankit Kumar Meena Puneet Kumar Choudhary Arvinder Wander Priyanka Madaan Source Type: research

Anogenital Herpes Simplex Virus Infection Mimics Sacral and Gluteal Pressure Injuries
Adv Skin Wound Care. 2024 Mar 1;37(3):122-124. doi: 10.1097/ASW.0000000000000102.NO ABSTRACTPMID:38393702 | DOI:10.1097/ASW.0000000000000102 (Source: Herpes)
Source: Herpes - February 23, 2024 Category: Infectious Diseases Authors: Igor Melnychuk Alexandra Gaither Source Type: research

Vaccines and Dementia: Part I. Non-Specific Immune Boosting with BCG: History, Ligands, and Receptors
J Alzheimers Dis. 2024 Feb 20. doi: 10.3233/JAD-231315. Online ahead of print.ABSTRACTVaccines such as Bacille Calmette-Guérin (BCG) can apparently defer dementia onset with an efficacy better than all drugs known to date, as initially reported by Gofrit et al. (PLoS One14, e0224433), now confirmed by other studies. Understanding how and why is of immense importance because it could represent a sea-change in how we manage patients with mild cognitive impairment through to dementia. Given that infection and/or inflammation are likely to contribute to the development of dementias such as Alzheimer's disease (Part II of this...
Source: Herpes - February 23, 2024 Category: Infectious Diseases Authors: Charles L Greenblatt Richard Lathe Source Type: research

Vaccines and Dementia: Part II. Efficacy of BCG and Other Vaccines Against Dementia
J Alzheimers Dis. 2024 Feb 19. doi: 10.3233/JAD-231323. Online ahead of print.ABSTRACT There is growing awareness that infections may contribute to the development of senile dementia including Alzheimer's disease (AD), and that immunopotentiation is therefore a legitimate target in the management of diseases of the elderly including AD. In Part I of this work, we provided a historical and molecular background to how vaccines, adjuvants, and their component molecules can elicit broad-spectrum protective effects against diverse agents, culminating in the development of the tuberculosis vaccine strain Bacille Calmette-Guérin...
Source: Herpes - February 23, 2024 Category: Infectious Diseases Authors: Charles L Greenblatt Richard Lathe Source Type: research

Etiology of Meningoencephalitis in children aged less than 5 years
CONCLUSION: We identified the etiological agents in 50/130 (38.5%) suspected ME cases in children less than 5 years of age, using molecular and ELISA-based diagnostic methods. The four most common pathogens detected were JEV, adenovirus, influenza virus, and dengue virus.PMID:38394398 | DOI:10.4103/ijpm.ijpm_60_23 (Source: Herpes)
Source: Herpes - February 23, 2024 Category: Infectious Diseases Authors: Vivek K Mishra Tanzeela Khan Amar Jeet Om Prakash None Chandrakanta Ashish K Srivastava Sangram Singh Neelam Pathak Amita Jain Source Type: research

Impact of the pandemic on various infectious diseases with different epidemiological patterns of seasonality, transmission and age
CONCLUSIONS: The impact of the pandemic is very different in these diseases. Pediatric and respiratory-transmitted seasonal viral infections are the ones that are most affected, but with different patterns of recovery to normality. Gastrointestinal bacterial infections suffer fewer variations, except for rotavirus. Gonorrhea do not interrupt its increasing trend seen in the pre-pandemic. Shingles show a slight post-pandemic increase. Several diseases with different epidemiological patterns have been studied for a sufficient period to observe how the acute phase of the pandemic emerges.PMID:38385502 (Source: Herpes)
Source: Herpes - February 22, 2024 Category: Infectious Diseases Authors: Juan Carlos Gasc ó-Laborda M Dolores Tirado-Balaguer Mar ía Gil-Fortuño Gabriela Dorina Deaconescu Oihana Sabalza-Bazt án Óscar Pérez-Olaso Iris G ómez-Alfaro Noelia Hern ández-Pérez Juan B Bellido-Blasco Source Type: research