Real-Life Comparison of Four JAK Inhibitors in Rheumatoid Arthritis (ELECTRA- < em > i < /em > Study)
Conclusions: Our real-world data from patients with RA show differences in some laboratory parameters and in the impact of lipid metabolism in JAK inhibitor treatment.PMID:38542045 | DOI:10.3390/jcm13061821 (Source: Herpes)
Source: Herpes - March 28, 2024 Category: Infectious Diseases Authors: Maurizio Benucci Francesca Li Gobbi Arianna Damiani Edda Russo Serena Guiducci Mariangela Manfredi Barbara Lari Valentina Grossi Maria Infantino Source Type: research
Major Virion Tegument Protein VP22 Targets Nuclear Matrix and Chromatin upon Entry into Cells during Productive Herpes Simplex Virus 1 Infection
Microorganisms. 2024 Mar 5;12(3):521. doi: 10.3390/microorganisms12030521.ABSTRACTHSV-1 major tegument protein VP22 is present in multiple subcellular locations in the late stages of productive viral infection. We initially performed a detailed time course experiment and observed that VP22 was detected in nuclear and nuclear matrix fractions as early as 4 hpi. The goal was to determine the fate of virion-derived incoming VP22, and we report the following: (i) VP22 was detected in nuclear matrix fractions 1 hpi. (ii) In the presence of cycloheximide (CHX), VP22 was present in the nuclear matrix 1-6 hpi, demonstrating the st...
Source: Herpes - March 28, 2024 Category: Infectious Diseases Authors: Isabella Chi John A Blaho Source Type: research
A Specific Pattern of Routine Cerebrospinal Fluid Parameters Might Help to Identify Cases of West Nile Virus Neuroinvasive Disease
CONCLUSIONS: Cases with WNV ME showed a specific pattern of routine CSF parameters and demographic data that allowed for their identification with good accuracy. These findings might help to guide the diagnostic workup in cases with viral ME, in particular allowing the timely identification of cases with ME due to WNV.PMID:38543707 | PMC:PMC10974314 | DOI:10.3390/v16030341 (Source: Herpes)
Source: Herpes - March 28, 2024 Category: Infectious Diseases Authors: Johann Otto Pelz Christoph M ühlberg Isabel Friedrich Lorenz Weidhase Silke Zimmermann Melanie Maier Corinna Pietsch Source Type: research
Herpes Simplex Virus Bronchopneumonitis in Critically Ill Patients with Acute on Chronic Liver Failure: A Retrospective Analysis
Conclusions: Mortality of critically ill patients with ACLF with HSV bronchopneumonitis was not increased in spite of the cirrhosis-associated immune dysfunction. Their clinical course, however, was more complicated with significantly longer mechanical ventilation.PMID:38543784 | PMC:PMC10974938 | DOI:10.3390/v16030419 (Source: Herpes)
Source: Herpes - March 28, 2024 Category: Infectious Diseases Authors: Miriam Dibos Julian Triebelhorn Jochen Schneider Sebastian Rasch Roland M Schmid Tobias Lahmer Ulrich Mayr Source Type: research
Herpes Zoster and Cardiovascular Disease: Exploring Associations and Preventive Measures through Vaccination
Vaccines (Basel). 2024 Feb 28;12(3):252. doi: 10.3390/vaccines12030252.ABSTRACTHerpes zoster, induced by the reactivation of the varicella-zoster virus (VZV), is a unilaterally distributed vesicular rash that can cause multiple complications. VZV not only causes neurological problems, including postherpetic neuralgia and ocular zoster, but also causes inflammatory vasculopathy and increases the incidence of hemorrhagic or ischemic complications. Therefore, understanding the association between the development of herpes zoster and the subsequent occurrence of acute stroke or cardiovascular diseases, including myocardial inf...
Source: Herpes - March 28, 2024 Category: Infectious Diseases Authors: Minako Yamaoka-Tojo Taiki Tojo Source Type: research
Baculovirus Vector-Based Varicella-Zoster Virus Vaccine as a Promising Alternative with Enhanced Safety and Therapeutic Functions
Vaccines (Basel). 2024 Mar 20;12(3):333. doi: 10.3390/vaccines12030333.ABSTRACTVaricella-zoster virus (VZV) poses lifelong risks, causing varicella and herpes zoster (HZ, shingles). Currently, varicella and HZ vaccines are predominantly live attenuated vaccines or adjuvanted subunit vaccines utilizing VZV glycoprotein E (gE). Here, we propose our vaccine candidates involving a comparative analysis between recombinant baculoviral vector vaccines (AcHERV) and a live attenuated vaccine strain, vOka. AcHERV vaccine candidates were categorized into groups encoding gE only, VZV glycoprotein B (gB) only, or both gE and gB (gE-gB)...
Source: Herpes - March 28, 2024 Category: Infectious Diseases Authors: Chanyeong Lee Minjee Kim Jungmin Chun Sehyun Kim Doyoung Yoon Hyeondong Lee Heewon Bang Hee-Jung Lee Hosun Park Young Bong Kim Source Type: research
Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Herpes)
Source: Herpes - March 28, 2024 Category: Infectious Diseases Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research
Nanopore sequencing in distinguishing between wild-type and vaccine strains of Varicella-Zoster virus
CONCLUSION: This study validates that nanopore sequencing is a reliable method for differentiating between the wild-type and vaccine strains of VZV. Its ability to produce long-read sequences is remarkable, allowing simultaneous confirmation of known SNPs and the detection of new mutations. Nanopore sequencing can serve as a valuable tool for the swift and precise identification of wild-type and vaccine strains and has potential applications in future VZV surveillance.PMID:38548526 | DOI:10.1016/j.vaccine.2024.03.046 (Source: Herpes)
Source: Herpes - March 28, 2024 Category: Infectious Diseases Authors: Yuto Fukuda Takako Suzuki Ken-Ichi Iwata Kazunori Haruta Makoto Yamaguchi Yuka Torii Atsushi Narita Hideki Muramatsu Yoshiyuki Takahashi Jun-Ichi Kawada Source Type: research
Systematic review and network meta-analysis of the risk of Herpes zoster with biological therapies and selective Janus kinase-1 inhibitors in atopic dermatitis
CONCLUSIONS: JAK-1 inhibitors are associated with a significantly higher incidence of HZ compared to dupilumab and placebo. Our results suggest that recombinant HZ vaccination should be highly considered for all adult patients prior to starting oral JAK-1 inhibitors.PMID:38533363 | PMC:PMC10962383 | DOI:10.5114/ada.2023.135764 (Source: Herpes)
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Daud Manzar Nikhil Nair Emmanuel Suntres Myanca Rodrigues Mohannad Abu-Hilal Source Type: research
Effective vaccination strategies for human papillomavirus (HPV) infection and cervical cancer based on the mathematical model with a stochastic process
In this study, a mathematical model with stochastic processes was developed to analyze HPV transmission between genders and its subsequent impact on cervical cancer incidence. The model simulations suggest that both-gender vaccination is far more effective than female-only vaccination in preventing an increase in cervical cancer incidence. With increasing stochasticity, the difference between the number of patients in the vaccinated group and the number in the nonvaccinated group diminishes. To distinguish the patient population distribution of the vaccinated from the nonvaccinated, we calculated effect size (Cohen's dista...
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Minsoo Kim Eunjung Kim Source Type: research
Impact of Genital Infections and Antibiotic Use on Incidence of Preterm Birth: A Retrospective Observational Study
This study investigates the complex interplay among genital infections, antibiotic usage, and preterm birth. This study aims to identify common genital pathogens associated with preterm births, assess the impact of various antibiotic treatments on pregnancy outcomes, and understand antibiotic resistance patterns among these pathogens. This study included 71 pregnant women who experienced preterm birth and 94 women with genital infections who delivered at term. Various maternal characteristics, medical history, signs and symptoms, gestational weight, gestational age, type of birth, vaginal pH, Nugent scores, and vaginal flo...
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Daniela Teodora Marti Felix Bratosin Ovidiu Rosca Roxana Folescu Cosmin Citu Adrian Ratiu Zoran Laurentiu Popa Source Type: research
Viral Infections, Are They a Trigger and Risk Factor of Alzheimer's Disease?
Pathogens. 2024 Mar 8;13(3):240. doi: 10.3390/pathogens13030240.ABSTRACTAlzheimer's Disease (AD), a progressive and debilitating condition, is reported to be the most common type of dementia, with at least 55 million people believed to be currently affected. Many causation hypotheses of AD exist, yet the intriguing link between viral infection and its possible contribution to the known etiology of AD has become an attractive focal point of research for the field and a challenging study task. In this review, we will explore the historical perspective and milestones that led the field to investigate the viral connection to A...
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Meagan D Rippee-Brooks Wenzhe Wu Jianli Dong Miguel Pappolla Xiang Fang Xiaoyong Bao Source Type: research
Function and Mechanism of Antiviral Wasp Venom Peptide Protopolybia-MP III and Its Derivatives against HSV-1
Toxins (Basel). 2024 Mar 4;16(3):132. doi: 10.3390/toxins16030132.ABSTRACTViruses are one of the leading causes of human disease, and many highly pathogenic viruses still have no specific treatment drugs. Therefore, producing new antiviral drugs is an urgent matter. In our study, we first found that the natural wasp venom peptide Protopolybia-MP III had a significant inhibitory effect on herpes simplex virus type 1 (HSV-1) replication in vitro by using quantitative real-time PCR (qPCR), Western blotting, and plaque-forming assays. Immunofluorescence analysis showed Protopolybia-MP III could enter cells, and it inhibited mu...
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Fang Sun Xiangdong Ye Tanran Han Jingwen Xia Lili Wu Wen Zhu Li Ding Xudong Luo Chenhu Qin Zongyun Chen Source Type: research
OH2 oncolytic virus: A novel approach to glioblastoma intervention through direct targeting of tumor cells and augmentation of anti-tumor immune responses
This study marks the first demonstration of an HSV-2 derived OV's effectiveness against GBM. Significantly, these discoveries have driven the initiation of a phase I/II clinical trial (ClinicalTrials.gov: NCT05235074). This trial is designed to explore the potential of OH2 as a therapeutic option for patients with recurrent central nervous system tumors following surgical intervention.PMID:38537773 | DOI:10.1016/j.canlet.2024.216834 (Source: Herpes)
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Yi Zheng Xiaomin Wang Qiang Ji Aizhong Fang Lairong Song Xiaoying Xu Yi Lin Yichen Peng Jianyu Yu Lei Xie Feng Chen Xiaojie Li Sipeng Zhu Botao Zhang Lili Zhou Chunna Yu YaLi Wang Liang Wang Han Hu Ziyi Zhang Binlei Liu Zhen Wu Wenbin Li Source Type: research
Impact of Toll-Like Receptors (TLRs) and TLR Signaling Proteins in Trigeminal Ganglia Impairing Herpes Simplex Virus 1 (HSV-1) Progression to Encephalitis: Insights from Mouse Models
Front Biosci (Landmark Ed). 2024 Mar 14;29(3):102. doi: 10.31083/j.fbl2903102.ABSTRACTHerpes simplex virus 1 (HSV-1) or simplexvirus humanalpha 1 is a neurotropic virus that is responsible for orofacial infections in humans. More than 70% of the world's population may have seropositivity for HSV-1, and this virus is a leading cause of sporadic lethal encephalitis in humans. The role of toll-like receptors (TLRs) in defending against HSV-1 infection has been explored, including the consequences of lacking these receptors or other proteins in the TLR pathway. Cell and mouse models have been used to study the importance of th...
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Marco Ant ônio Campos Guilherme de P ádua Zolini Erna Geessien Kroon Source Type: research
