Should we promote vaccination against the herpes zoster virus?
Arch Soc Esp Oftalmol (Engl Ed). 2024 Apr 7:S2173-5794(24)00058-6. doi: 10.1016/j.oftale.2024.02.008. Online ahead of print.NO ABSTRACTPMID:38593978 | DOI:10.1016/j.oftale.2024.02.008 (Source: Herpes)
Source: Herpes - April 9, 2024 Category: Infectious Diseases Authors: C Rocha-de-Lossada G Rocha-de-Lossada M Rocha-de-Lossada A Rocha-Bogas Source Type: research
Janus kinase inhibitors and tumour necrosis factor inhibitors show a favourable safety profile and similar persistence in rheumatoid arthritis, psoriatic arthritis and spondyloarthritis: real-world data from the BIOBADASER registry
CONCLUSIONS: Infections, herpes zoster and gastrointestinal adverse events in patients with RA tended to be more frequent with JAKi. However, prognosis was poor in patients receiving JAKi. Persistence was similar for TNFi and JAKi, although factors associated with discontinuation differed by diagnostic group.PMID:38594056 | DOI:10.1136/ard-2023-225271 (Source: Herpes)
Source: Herpes - April 9, 2024 Category: Infectious Diseases Authors: Blanca Hern ández-Cruz Luc ía Otero-Varela Mercedes Freire-Gonz ález Noem í Busquets-Pérez Alfredo Javier Garc ía González Manuel Moreno-Ramos Juan Maria Blanco-Madrigal Sara Manrique-Arija Eva Perez-Pampin Dolores Ruiz-Montesino Fernando S ánchez Source Type: research
Management of Herpes Zoster Infection Using a Combination of Allopathic and Herbal Medication: A Case Report
Cureus. 2024 Mar 7;16(3):e55705. doi: 10.7759/cureus.55705. eCollection 2024 Mar.ABSTRACTHerpes zoster (HZ) also known as shingles is the reactivation of varicella-zoster virus (VZV) that causes chickenpox. It usually occurs in adults after remaining dormant in the dorsal root ganglia or ganglia of the cranial nerves for several years. It typically manifests as vesicle crops in a dermatomal or "zosteriform" pattern, which shows vesicle, ulcer, and scab distribution that is unilateral, clustered, and linear in a dermatome that is supplied by a single nerve. Patients usually experience prodromal symptoms of deep, severe achi...
Source: Herpes - April 8, 2024 Category: Infectious Diseases Authors: Rosalyn Lalremtluangi Suwarna Dangore-Khasbage Rahul R Bhowate Source Type: research
Herpes simplex virus infection with a marginal Nikolsky sign in an immunocompromised patient
J Dermatol. 2024 Apr 8. doi: 10.1111/1346-8138.17224. Online ahead of print.NO ABSTRACTPMID:38587235 | DOI:10.1111/1346-8138.17224 (Source: Herpes)
Source: Herpes - April 8, 2024 Category: Infectious Diseases Authors: Eriko Takayama Akiko Yoshioka Source Type: research
Therapeutic prime/pull vaccination of HSV-2-infected guinea pigs with the ribonucleotide reductase 2 (RR2) protein and CXCL11 chemokine boosts antiviral local tissue-resident and effector memory CD4(+) and CD8(+) T cells and protects against recurrent genital herpes
In this study, we used the strategy that involves immunization of herpes simplex virus type 2-infected guinea pigs using a recombinantly expressed herpes tegument protein-ribonucleotide reductase 2 (RR2; prime), followed by intravaginal treatment with the neurotropic adeno-associated virus type 8 expressing CXCL9, CXCL10, or CXCL11 T-cell-attracting chemokines to recruit T cells into the infected dorsal root ganglia (DRG) and vaginal mucosa (VM) (pull). We show that the RR2/CXCL11 prime-pull therapeutic vaccine strategy elicited a significant reduction in virus shedding in the vaginal mucosa and decreased the severity and ...
Source: Herpes - April 8, 2024 Category: Infectious Diseases Authors: Afshana Quadiri Swayam Prakash Nisha Rajeswari Dhanushkodi Mahmoud Singer Latifa Zayou Amin Mohammed Shaik Miyo Sun Berfin Suzer Lauren Su Lin Lau Amruth Chilukurri Hawa Vahed Hubert Schaefer Lbachir BenMohamed Source Type: research
Narrative Review on the Use of Cladribine Tablets as Exit Therapy for Stable Elderly Patients with Multiple Sclerosis
Neurol Ther. 2024 Apr 8. doi: 10.1007/s40120-024-00603-y. Online ahead of print.ABSTRACTThe number of ageing people with relapsing multiple sclerosis (RMS) is increasing. The efficacy of disease-modifying therapies (DMTs) for RMS declines with age. Also, older persons with MS may be more susceptible to infections, hospitalisations and malignancy. Aging people with MS have higher rates of comorbidities versus aged-matched controls, increasing the individual risk of disability. We review the therapeutic properties of cladribine tablets (CladT) in ageing people with RMS, with regard to their utility for allowing these individ...
Source: Herpes - April 8, 2024 Category: Infectious Diseases Authors: Jerome de Seze Dominique Dive Xavier Ayrignac Giovanni Castelnovo Marianne Payet Amel Rayah Claudio Gobbi Patrick Vermersch Chiara Zecca Source Type: research
Bilateral Pattern Electroretinogram Abnormalities in Patients with Herpes Zoster Keratitis and Conjunctivitis
CONCLUSIONS: Our results showed that VZV-affected eyes without central cornea involvement displayed reduced N95 amplitude and prolonged P50 peak time in bilateral eyes compared to the healthy controls. Larger studies are needed to further explore the effect of HZO on the electrophysiological response of the eye and the posterior segment.PMID:38587772 | DOI:10.1007/s40123-024-00928-9 (Source: Herpes)
Source: Herpes - April 8, 2024 Category: Infectious Diseases Authors: Jingyi Li Yuexin Wang Xin Xie Weizhen Zeng Shiying Li Rupesh Agrawal Yun Feng Source Type: research
Lack of functional TCR-epitope interaction is associated with herpes zoster through reduced downstream T cell activation
Cell Rep. 2024 Apr 7;43(4):114062. doi: 10.1016/j.celrep.2024.114062. Online ahead of print.ABSTRACTThe role of T cell receptor (TCR) diversity in infectious disease susceptibility is not well understood. We use a systems immunology approach on three cohorts of herpes zoster (HZ) patients and controls to investigate whether TCR diversity against varicella-zoster virus (VZV) influences the risk of HZ. We show that CD4+ T cell TCR diversity against VZV glycoprotein E (gE) and immediate early 63 protein (IE63) after 1-week culture is more restricted in HZ patients. Single-cell RNA and TCR sequencing of VZV-specific T cells sh...
Source: Herpes - April 8, 2024 Category: Infectious Diseases Authors: Marlies Boeren Nicky de Vrij My K Ha Sebastiaan Valkiers Aisha Souquette Sofie Gielis Mariia Kuznetsova Jolien Schippers Esther Bartholomeus Johan Van den Bergh Nele Michels Olivier Aerts Julie Leysen An Bervoets Julien Lambert Elke Leuridan Johan Wens Ka Source Type: research
Management of Herpes Zoster Infection Using a Combination of Allopathic and Herbal Medication: A Case Report
Cureus. 2024 Mar 7;16(3):e55705. doi: 10.7759/cureus.55705. eCollection 2024 Mar.ABSTRACTHerpes zoster (HZ) also known as shingles is the reactivation of varicella-zoster virus (VZV) that causes chickenpox. It usually occurs in adults after remaining dormant in the dorsal root ganglia or ganglia of the cranial nerves for several years. It typically manifests as vesicle crops in a dermatomal or "zosteriform" pattern, which shows vesicle, ulcer, and scab distribution that is unilateral, clustered, and linear in a dermatome that is supplied by a single nerve. Patients usually experience prodromal symptoms of deep, severe achi...
Source: Herpes - April 8, 2024 Category: Infectious Diseases Authors: Rosalyn Lalremtluangi Suwarna Dangore-Khasbage Rahul R Bhowate Source Type: research
Development of a High-throughput Sequencing Platform for Detection of Viral Encephalitis Pathogens Based on Amplicon Sequencing
CONCLUSION: Amplicon-based high-throughput sequencing technology is feasible as a supplementary method for the pathogenic detection of viral encephalitis. It is also a useful tool for the high-volume screening of clinical samples.PMID:38582993 | DOI:10.3967/bes2024.032 (Source: Herpes)
Source: Herpes - April 7, 2024 Category: Infectious Diseases Authors: Ya Li Zhang Wen Zhe Su Rui Chen Wang Yan Li Jun Feng Zhang Sheng Hui Liu Dan He Hu Chong Xiao Xu Jia Yu Yin Qi Kai Yin Ying He Fan Li Shi Hong Fu Kai Nie Guo Dong Liang Yong Tao Song Tao Xu Chao Feng Ma Huan Yu Wang Source Type: research
Acute gastric dilatation with segmented abdominal paresis as a rare manifestation of herpes zoster: a case report and review of the literature
CONCLUSION: Acute gastric dilatation with abdominal paresis is an extremely rare complication of herpes zoster infection, and to date there have been no reports in the literature. It alerts us that, when examining patients with abdominal bulge, we should be conscious of this rare pathology for the optical diagnosis, avoiding unnecessary invasive examination or surgical exploration.PMID:38584287 | DOI:10.1186/s13256-024-04487-2 (Source: Herpes)
Source: Herpes - April 7, 2024 Category: Infectious Diseases Authors: Toshihiko Yagyu Yoshikazu Yakami Tomoki Bando Source Type: research
Mehr Klinikeinweisungen wegen Herpes Zoster bei Diabetes
MMW Fortschr Med. 2024 Apr;166(6):21. doi: 10.1007/s15006-024-3784-8.NO ABSTRACTPMID:38581497 | DOI:10.1007/s15006-024-3784-8 (Source: Herpes)
Source: Herpes - April 6, 2024 Category: Infectious Diseases Authors: Elke Oberhofer Source Type: research
Safety profile of recombinant adjuvanted anti-herpes zoster vaccine (RZV) in high-risk groups: Data from active surveillance program. Puglia (Italy), 2021-23
CONCLUSIONS: The study demonstrates RZV safety in a significant number of high-risk patients. Hence, RZV should be actively offered as part of tailored vaccination programs to decrease the burden of HZ in fragile populations.PMID:38582693 | DOI:10.1016/j.vaccine.2024.03.024 (Source: Herpes)
Source: Herpes - April 6, 2024 Category: Infectious Diseases Authors: Pasquale Stefanizzi Lorenza Moscara Claudia Palmieri Andrea Martinelli Antonio Di Lorenzo Vincenzo Venerito Cinzia Annatea Germinario Silvio Tafuri Source Type: research
Mehr Klinikeinweisungen wegen Herpes Zoster bei Diabetes
MMW Fortschr Med. 2024 Apr;166(6):21. doi: 10.1007/s15006-024-3784-8.NO ABSTRACTPMID:38581497 | DOI:10.1007/s15006-024-3784-8 (Source: Herpes)
Source: Herpes - April 6, 2024 Category: Infectious Diseases Authors: Elke Oberhofer Source Type: research
New hopes for the breast cancer treatment: perspectives on the oncolytic virus therapy
Front Immunol. 2024 Mar 21;15:1375433. doi: 10.3389/fimmu.2024.1375433. eCollection 2024.ABSTRACTOncolytic virus (OV) therapy has emerged as a promising frontier in cancer treatment, especially for solid tumours. While immunotherapies like immune checkpoint inhibitors and CAR-T cells have demonstrated impressive results, their limitations in inducing complete tumour regression have spurred researchers to explore new approaches targeting tumours resistant to current immunotherapies. OVs, both natural and genetically engineered, selectively replicate within cancer cells, inducing their lysis while sparing normal tissues. Rec...
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Hanna Chowaniec Antonina Ślubowska Magdalena Mroczek Martyna Borowczyk Ma łgorzata Braszka Grzegorz Dworacki Paula Dobosz Mateusz Wichtowski Source Type: research
