Systematic review and network meta-analysis of the risk of Herpes zoster with biological therapies and selective Janus kinase-1 inhibitors in atopic dermatitis
CONCLUSIONS: JAK-1 inhibitors are associated with a significantly higher incidence of HZ compared to dupilumab and placebo. Our results suggest that recombinant HZ vaccination should be highly considered for all adult patients prior to starting oral JAK-1 inhibitors.PMID:38533363 | PMC:PMC10962383 | DOI:10.5114/ada.2023.135764 (Source: Herpes)
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Daud Manzar Nikhil Nair Emmanuel Suntres Myanca Rodrigues Mohannad Abu-Hilal Source Type: research
Effective vaccination strategies for human papillomavirus (HPV) infection and cervical cancer based on the mathematical model with a stochastic process
In this study, a mathematical model with stochastic processes was developed to analyze HPV transmission between genders and its subsequent impact on cervical cancer incidence. The model simulations suggest that both-gender vaccination is far more effective than female-only vaccination in preventing an increase in cervical cancer incidence. With increasing stochasticity, the difference between the number of patients in the vaccinated group and the number in the nonvaccinated group diminishes. To distinguish the patient population distribution of the vaccinated from the nonvaccinated, we calculated effect size (Cohen's dista...
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Minsoo Kim Eunjung Kim Source Type: research
Impact of Genital Infections and Antibiotic Use on Incidence of Preterm Birth: A Retrospective Observational Study
This study investigates the complex interplay among genital infections, antibiotic usage, and preterm birth. This study aims to identify common genital pathogens associated with preterm births, assess the impact of various antibiotic treatments on pregnancy outcomes, and understand antibiotic resistance patterns among these pathogens. This study included 71 pregnant women who experienced preterm birth and 94 women with genital infections who delivered at term. Various maternal characteristics, medical history, signs and symptoms, gestational weight, gestational age, type of birth, vaginal pH, Nugent scores, and vaginal flo...
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Daniela Teodora Marti Felix Bratosin Ovidiu Rosca Roxana Folescu Cosmin Citu Adrian Ratiu Zoran Laurentiu Popa Source Type: research
Viral Infections, Are They a Trigger and Risk Factor of Alzheimer's Disease?
Pathogens. 2024 Mar 8;13(3):240. doi: 10.3390/pathogens13030240.ABSTRACTAlzheimer's Disease (AD), a progressive and debilitating condition, is reported to be the most common type of dementia, with at least 55 million people believed to be currently affected. Many causation hypotheses of AD exist, yet the intriguing link between viral infection and its possible contribution to the known etiology of AD has become an attractive focal point of research for the field and a challenging study task. In this review, we will explore the historical perspective and milestones that led the field to investigate the viral connection to A...
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Meagan D Rippee-Brooks Wenzhe Wu Jianli Dong Miguel Pappolla Xiang Fang Xiaoyong Bao Source Type: research
Function and Mechanism of Antiviral Wasp Venom Peptide Protopolybia-MP III and Its Derivatives against HSV-1
Toxins (Basel). 2024 Mar 4;16(3):132. doi: 10.3390/toxins16030132.ABSTRACTViruses are one of the leading causes of human disease, and many highly pathogenic viruses still have no specific treatment drugs. Therefore, producing new antiviral drugs is an urgent matter. In our study, we first found that the natural wasp venom peptide Protopolybia-MP III had a significant inhibitory effect on herpes simplex virus type 1 (HSV-1) replication in vitro by using quantitative real-time PCR (qPCR), Western blotting, and plaque-forming assays. Immunofluorescence analysis showed Protopolybia-MP III could enter cells, and it inhibited mu...
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Fang Sun Xiangdong Ye Tanran Han Jingwen Xia Lili Wu Wen Zhu Li Ding Xudong Luo Chenhu Qin Zongyun Chen Source Type: research
OH2 oncolytic virus: A novel approach to glioblastoma intervention through direct targeting of tumor cells and augmentation of anti-tumor immune responses
This study marks the first demonstration of an HSV-2 derived OV's effectiveness against GBM. Significantly, these discoveries have driven the initiation of a phase I/II clinical trial (ClinicalTrials.gov: NCT05235074). This trial is designed to explore the potential of OH2 as a therapeutic option for patients with recurrent central nervous system tumors following surgical intervention.PMID:38537773 | DOI:10.1016/j.canlet.2024.216834 (Source: Herpes)
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Yi Zheng Xiaomin Wang Qiang Ji Aizhong Fang Lairong Song Xiaoying Xu Yi Lin Yichen Peng Jianyu Yu Lei Xie Feng Chen Xiaojie Li Sipeng Zhu Botao Zhang Lili Zhou Chunna Yu YaLi Wang Liang Wang Han Hu Ziyi Zhang Binlei Liu Zhen Wu Wenbin Li Source Type: research
Impact of Toll-Like Receptors (TLRs) and TLR Signaling Proteins in Trigeminal Ganglia Impairing Herpes Simplex Virus 1 (HSV-1) Progression to Encephalitis: Insights from Mouse Models
Front Biosci (Landmark Ed). 2024 Mar 14;29(3):102. doi: 10.31083/j.fbl2903102.ABSTRACTHerpes simplex virus 1 (HSV-1) or simplexvirus humanalpha 1 is a neurotropic virus that is responsible for orofacial infections in humans. More than 70% of the world's population may have seropositivity for HSV-1, and this virus is a leading cause of sporadic lethal encephalitis in humans. The role of toll-like receptors (TLRs) in defending against HSV-1 infection has been explored, including the consequences of lacking these receptors or other proteins in the TLR pathway. Cell and mouse models have been used to study the importance of th...
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Marco Ant ônio Campos Guilherme de P ádua Zolini Erna Geessien Kroon Source Type: research
Systematic review and network meta-analysis of the risk of Herpes zoster with biological therapies and selective Janus kinase-1 inhibitors in atopic dermatitis
CONCLUSIONS: JAK-1 inhibitors are associated with a significantly higher incidence of HZ compared to dupilumab and placebo. Our results suggest that recombinant HZ vaccination should be highly considered for all adult patients prior to starting oral JAK-1 inhibitors.PMID:38533363 | PMC:PMC10962383 | DOI:10.5114/ada.2023.135764 (Source: Herpes)
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Daud Manzar Nikhil Nair Emmanuel Suntres Myanca Rodrigues Mohannad Abu-Hilal Source Type: research
Effective vaccination strategies for human papillomavirus (HPV) infection and cervical cancer based on the mathematical model with a stochastic process
In this study, a mathematical model with stochastic processes was developed to analyze HPV transmission between genders and its subsequent impact on cervical cancer incidence. The model simulations suggest that both-gender vaccination is far more effective than female-only vaccination in preventing an increase in cervical cancer incidence. With increasing stochasticity, the difference between the number of patients in the vaccinated group and the number in the nonvaccinated group diminishes. To distinguish the patient population distribution of the vaccinated from the nonvaccinated, we calculated effect size (Cohen's dista...
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Minsoo Kim Eunjung Kim Source Type: research
Impact of Genital Infections and Antibiotic Use on Incidence of Preterm Birth: A Retrospective Observational Study
This study investigates the complex interplay among genital infections, antibiotic usage, and preterm birth. This study aims to identify common genital pathogens associated with preterm births, assess the impact of various antibiotic treatments on pregnancy outcomes, and understand antibiotic resistance patterns among these pathogens. This study included 71 pregnant women who experienced preterm birth and 94 women with genital infections who delivered at term. Various maternal characteristics, medical history, signs and symptoms, gestational weight, gestational age, type of birth, vaginal pH, Nugent scores, and vaginal flo...
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Daniela Teodora Marti Felix Bratosin Ovidiu Rosca Roxana Folescu Cosmin Citu Adrian Ratiu Zoran Laurentiu Popa Source Type: research
Viral Infections, Are They a Trigger and Risk Factor of Alzheimer's Disease?
Pathogens. 2024 Mar 8;13(3):240. doi: 10.3390/pathogens13030240.ABSTRACTAlzheimer's Disease (AD), a progressive and debilitating condition, is reported to be the most common type of dementia, with at least 55 million people believed to be currently affected. Many causation hypotheses of AD exist, yet the intriguing link between viral infection and its possible contribution to the known etiology of AD has become an attractive focal point of research for the field and a challenging study task. In this review, we will explore the historical perspective and milestones that led the field to investigate the viral connection to A...
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Meagan D Rippee-Brooks Wenzhe Wu Jianli Dong Miguel Pappolla Xiang Fang Xiaoyong Bao Source Type: research
Function and Mechanism of Antiviral Wasp Venom Peptide Protopolybia-MP III and Its Derivatives against HSV-1
Toxins (Basel). 2024 Mar 4;16(3):132. doi: 10.3390/toxins16030132.ABSTRACTViruses are one of the leading causes of human disease, and many highly pathogenic viruses still have no specific treatment drugs. Therefore, producing new antiviral drugs is an urgent matter. In our study, we first found that the natural wasp venom peptide Protopolybia-MP III had a significant inhibitory effect on herpes simplex virus type 1 (HSV-1) replication in vitro by using quantitative real-time PCR (qPCR), Western blotting, and plaque-forming assays. Immunofluorescence analysis showed Protopolybia-MP III could enter cells, and it inhibited mu...
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Fang Sun Xiangdong Ye Tanran Han Jingwen Xia Lili Wu Wen Zhu Li Ding Xudong Luo Chenhu Qin Zongyun Chen Source Type: research
Associations between Different Antivirals and Hospital acquired Acute Kidney Injury in Adults with Herpes Zoster
CONCLUSIONS: Among antiviral therapies for herpes zoster, we found different risks of hospital acquired AKI among the patients receiving different antivirals, in particular, those administered intravenously. Among intravenous antivirals, acyclovir was associated with highest risk of hospital acquired AKI, followed by penciclovir/ganciclovir and foscarnet. Confirmation studies with large samples from other populations are warranted.PMID:38527975 | DOI:10.2215/CJN.0000000000000452 (Source: Herpes)
Source: Herpes - March 26, 2024 Category: Infectious Diseases Authors: Ruqi Xu Qi Gao Yuping Zhang Yuxin Lin Yanqin Li Licong Su Shiyu Zhou Yue Cao Peiyan Gao Pingping Li Fan Luo Ruixuan Chen Xiaodong Zhang Sheng Nie Xin Xu CRDS study Investigators Source Type: research
Infectious mononucleosis: new concepts in clinical presentation, epidemiology, and host response
Curr Opin Infect Dis. 2024 Mar 27. doi: 10.1097/QCO.0000000000001012. Online ahead of print.ABSTRACTPURPOSE OF THE REVIEW: Infectious mononucleosis (IM) is an infectious disease that presents clinically in only a small percentage of individuals despite almost universal infection with the causative agent. Here, we review the latest concepts in the clinical presentation, epidemiology, and host response of this disease.RECENT FINDINGS: Several recently published papers/reviews describe IM as a condition caused by one of several etiologic agents including, cytomegalovirus (HHV-5), Roseola virus (HHV-6) and Toxoplasmosis amongs...
Source: Herpes - March 26, 2024 Category: Infectious Diseases Authors: Patrick Naughton Frances Enright Brigid Lucey Source Type: research
Associations between Different Antivirals and Hospital acquired Acute Kidney Injury in Adults with Herpes Zoster
CONCLUSIONS: Among antiviral therapies for herpes zoster, we found different risks of hospital acquired AKI among the patients receiving different antivirals, in particular, those administered intravenously. Among intravenous antivirals, acyclovir was associated with highest risk of hospital acquired AKI, followed by penciclovir/ganciclovir and foscarnet. Confirmation studies with large samples from other populations are warranted.PMID:38527975 | DOI:10.2215/CJN.0000000000000452 (Source: Herpes)
Source: Herpes - March 26, 2024 Category: Infectious Diseases Authors: Ruqi Xu Qi Gao Yuping Zhang Yuxin Lin Yanqin Li Licong Su Shiyu Zhou Yue Cao Peiyan Gao Pingping Li Fan Luo Ruixuan Chen Xiaodong Zhang Sheng Nie Xin Xu CRDS study Investigators Source Type: research
