UVB induced reactivation leads to HSV1 in the corneas of virtually all latently infected mice and requires STING to develop corneal disease
Sci Rep. 2024 Mar 21;14(1):6859. doi: 10.1038/s41598-024-52597-0.ABSTRACTReactivation of latent herpes simplex type 1 results in virus returning to the cornea leading to recurrent herpetic stromal keratitis (rHSK). We compare two competing models to reactivate viruses from latency, UV-B irradiation and cyclophosphamide (CP). Results revealed that while both result in corneal recrudescence, only UV-B irradiation results in rHSK. To better understand the dynamics of reactivation, we analyzed corneas for both the presence of infectious viruses and the dynamics of exposure to multiple reactivations using UV-B. We noted that mu...
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Xiao-Tang Yin Alexis Hartman Nadia Sirajuddin Deepak Shukla Anthony St Leger Tammie L Keadle Patrick M Stuart Source Type: research
Navigating diagnostic challenges: imaging strategies for herpes simplex encephalitis in resource limited settings: A case report
Radiol Case Rep. 2024 Mar 13;19(6):2183-2187. doi: 10.1016/j.radcr.2024.02.060. eCollection 2024 Jun.ABSTRACTEncephalitis refers to the inflammatory condition affecting the brain parenchyma, leading to various neurological impairments. It can have various causes: infectious, postinfectious, and noninfectious origins. In this case, we present a 76-year-old man who presented to the emergency room with complaints of headache and behavioral changes. Initially, a Computed Tomography (CT) scan raised suspicion of herpes simplex encephalitis and prompted the initiation of treatment. Subsequently, Magnetic Resonance Imaging (MRI) ...
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Shimalis Tadasa Fayisa Nishma Pokharel Abisiniya Solomon Lense Negash Lidiya Ayele Biltibo Selamawit Hailu Bedasso Abel Tsehay Abebe Source Type: research
Expanded spectrum of varicella disease and the need for vaccination in India
Hum Vaccin Immunother. 2024 Dec 31;20(1):2328955. doi: 10.1080/21645515.2024.2328955. Epub 2024 Mar 22.ABSTRACTVaricella vaccine was first licensed in Japan and South Korea in 1989 for use in healthy children and was introduced in US in 1995. So far, 29 countries have adopted varicella vaccine in their universal immunization program (UIP). No Asian country, India included, has adopted the varicella vaccine as part of their UIP. The extra-cutaneous sites for VZV diseases are central nervous system and gastrointestinal tract, the expanded disease spectrum includes vasculopathy, myelitis, inflammatory bowel disease, perforate...
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Padma Srikanth Ilakkiya Arumugam Seetha N Jeganathan Rithvik Ramesh Lakshmi Narasimhan Ranganathan Shanthi Vijayaraghavan Source Type: research
Viral Anterior Uveitis: Differences in Retinal Vessel Area Density between the Affected and Non-Affected Eye Using Optical Coherence Tomography Angiography
CONCLUSION: We observed vascular dysfunction characterized by decreased macular and peripapillary VAD in the superficial plexus on OCTA in eyes with HSV- and VZV-positive VAU compared to non-affected fellow eyes. These changes might be an early sign of glaucomatous damage or may be a direct consequence of the herpes viruses themselves.PMID:38517389 | DOI:10.1080/09273948.2024.2329318 (Source: Herpes)
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Anna-Karina B Maier Daniel Mandrossa Emanuel Reitemeyer Sibylle Winterhalter Anne R übsam Uwe Pleyer Source Type: research
UVB induced reactivation leads to HSV1 in the corneas of virtually all latently infected mice and requires STING to develop corneal disease
Sci Rep. 2024 Mar 21;14(1):6859. doi: 10.1038/s41598-024-52597-0.ABSTRACTReactivation of latent herpes simplex type 1 results in virus returning to the cornea leading to recurrent herpetic stromal keratitis (rHSK). We compare two competing models to reactivate viruses from latency, UV-B irradiation and cyclophosphamide (CP). Results revealed that while both result in corneal recrudescence, only UV-B irradiation results in rHSK. To better understand the dynamics of reactivation, we analyzed corneas for both the presence of infectious viruses and the dynamics of exposure to multiple reactivations using UV-B. We noted that mu...
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Xiao-Tang Yin Alexis Hartman Nadia Sirajuddin Deepak Shukla Anthony St Leger Tammie L Keadle Patrick M Stuart Source Type: research
Navigating diagnostic challenges: imaging strategies for herpes simplex encephalitis in resource limited settings: A case report
Radiol Case Rep. 2024 Mar 13;19(6):2183-2187. doi: 10.1016/j.radcr.2024.02.060. eCollection 2024 Jun.ABSTRACTEncephalitis refers to the inflammatory condition affecting the brain parenchyma, leading to various neurological impairments. It can have various causes: infectious, postinfectious, and noninfectious origins. In this case, we present a 76-year-old man who presented to the emergency room with complaints of headache and behavioral changes. Initially, a Computed Tomography (CT) scan raised suspicion of herpes simplex encephalitis and prompted the initiation of treatment. Subsequently, Magnetic Resonance Imaging (MRI) ...
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Shimalis Tadasa Fayisa Nishma Pokharel Abisiniya Solomon Lense Negash Lidiya Ayele Biltibo Selamawit Hailu Bedasso Abel Tsehay Abebe Source Type: research
Immune response to the recombinant herpes zoster vaccine in people living with HIV over 50 years of age compared to non-HIV age-/gender-matched controls (SHINGR'HIV): a multicenter, international, non-randomized clinical trial study protocol
DISCUSSION: The SHINGR'HIV trial will provide robust data on the immunogenicity and safety profile of RZV in older PLWH to support vaccination guidelines in this population.TRIAL REGISTRATION: ClinicalTrials.gov NCT05575830. Registered on 12 October 2022. Eu Clinical Trial Register (EUCT number 2023-504482-23-00).PMID:38504173 | DOI:10.1186/s12879-024-09192-5 (Source: Herpes)
Source: Herpes - March 20, 2024 Category: Infectious Diseases Authors: Maxime Hentzien Fabrice Bonnet Enos Bernasconi Emmanuel Biver Dominique L Braun Aline Munting Karoline Leuzinger Olivier Leleux Stefano Musardo Virginie Prendki Patrick Schmid Cornelia Staehelin Marcel Stoeckle Carla S Walti Linda Wittkop Victor Appay Arn Source Type: research
PCR testing for herpesviruses in aqueous humor samples from patients with and without clinical corneal endothelial graft rejection
J Med Virol. 2024 Mar;96(3):e29538. doi: 10.1002/jmv.29538.ABSTRACTTo compare prevalence of positive PCR tests for herpesviruses between patients with and without a history of clinical corneal endothelial allograft rejection (AGR). Retrospective cross-sectional study with two-group comparison. A total of 307 aqueous humor (AH) samples from 235 Patients and 244 eyes who underwent penetrating keratoplasty or Descemet membrane endothelial keratoplasty or had a diagnostic AH aspiration due to clinical AGR between 2019 and 2023 were tested for DNA of herpes simplex virus (HSV), varicella-zoster virus (VZV), cytomegalovirus (CMV...
Source: Herpes - March 20, 2024 Category: Infectious Diseases Authors: Yaser Abu Dail Loay Daas Elias Flockerzi Cristian Munteanu Julian Kahlert Sigrun Smola Berthold Seitz Source Type: research
Immune response to the recombinant herpes zoster vaccine in people living with HIV over 50 years of age compared to non-HIV age-/gender-matched controls (SHINGR'HIV): a multicenter, international, non-randomized clinical trial study protocol
DISCUSSION: The SHINGR'HIV trial will provide robust data on the immunogenicity and safety profile of RZV in older PLWH to support vaccination guidelines in this population.TRIAL REGISTRATION: ClinicalTrials.gov NCT05575830. Registered on 12 October 2022. Eu Clinical Trial Register (EUCT number 2023-504482-23-00).PMID:38504173 | DOI:10.1186/s12879-024-09192-5 (Source: Herpes)
Source: Herpes - March 20, 2024 Category: Infectious Diseases Authors: Maxime Hentzien Fabrice Bonnet Enos Bernasconi Emmanuel Biver Dominique L Braun Aline Munting Karoline Leuzinger Olivier Leleux Stefano Musardo Virginie Prendki Patrick Schmid Cornelia Staehelin Marcel Stoeckle Carla S Walti Linda Wittkop Victor Appay Arn Source Type: research
PCR testing for herpesviruses in aqueous humor samples from patients with and without clinical corneal endothelial graft rejection
J Med Virol. 2024 Mar;96(3):e29538. doi: 10.1002/jmv.29538.ABSTRACTTo compare prevalence of positive PCR tests for herpesviruses between patients with and without a history of clinical corneal endothelial allograft rejection (AGR). Retrospective cross-sectional study with two-group comparison. A total of 307 aqueous humor (AH) samples from 235 Patients and 244 eyes who underwent penetrating keratoplasty or Descemet membrane endothelial keratoplasty or had a diagnostic AH aspiration due to clinical AGR between 2019 and 2023 were tested for DNA of herpes simplex virus (HSV), varicella-zoster virus (VZV), cytomegalovirus (CMV...
Source: Herpes - March 20, 2024 Category: Infectious Diseases Authors: Yaser Abu Dail Loay Daas Elias Flockerzi Cristian Munteanu Julian Kahlert Sigrun Smola Berthold Seitz Source Type: research
Persistent hypernatremia secondary to adipsic central diabetes insipidus in a patient with herpes-induced meningoencephalitis and COVID-19 infection: a case report
J Int Med Res. 2024 Mar;52(3):3000605241235747. doi: 10.1177/03000605241235747.ABSTRACTCentral diabetes insipidus (CDI) typically manifests as a polyuria-polydipsia syndrome, in which normonatremia is generally maintained through the polydipsia. A 53-year-old woman presented with diabetic ketosis and hyperosmolar hyperglycemic syndrome. Her medical history included herpes meningoencephalitis, which was associated with confusion and amnesia. On physical examination, she was apyretic, confused, and had signs of extracellular dehydration. Her capillary glucose concentration was high and her urine was positive for ketones. Lab...
Source: Herpes - March 19, 2024 Category: Infectious Diseases Authors: Faten Cherchir Ibtissem Oueslati Salma Salhi Asma Ben Hamida Meriem Yazidi Melika Chihaoui Source Type: research
Attitudes, barriers, and facilitators to adherent completion of the recombinant zoster vaccine regimen in Canada: Qualitative interviews with healthcare providers and patients
In conclusion, many factors can influence RZV series completion and adherence among adults in Canada, including cost, insurance coverage, HCP knowledge and encouragement, and reminders. Awareness of these factors may inform HCPs in helping patients overcome barriers and identify opportunities for future consideration, facilitating protection against herpes zoster.PMID:38502342 | DOI:10.1080/21645515.2024.2317595 (Source: Herpes)
Source: Herpes - March 19, 2024 Category: Infectious Diseases Authors: Sydney George Jessica Regan Amnah Awan Meaghan O'Connor April Foster Kimberly Raymond Iris Gorfinkel Shelly A McNeil Source Type: research
Efficacy and safety of pharmacological treatment of psoriatic arthritis: a systematic literature research informing the 2023 update of the EULAR recommendations for the management of psoriatic arthritis
CONCLUSION: The results of this SLR informed the task force responsible for the 2023 update of the European Alliance of Associations for Rheumatology recommendations for pharmacological management of PsA.PMID:38503473 | DOI:10.1136/ard-2024-225534 (Source: Herpes)
Source: Herpes - March 19, 2024 Category: Infectious Diseases Authors: Andreas Kerschbaumer Josef S Smolen Ricardo J O Ferreira Heidi Bertheussen Xenofon Baraliakos Daniel Aletaha Dennis G McGonagle D ésirée van der Heijde Iain B McInnes Bente Appel Esbensen Kevin L Winthrop Wolf-Henning Boehncke Jan W Schoones Laure Gosse Source Type: research
Efficacy and safety of filgotinib for ulcerative colitis: A real-world multicenter retrospective study in Japan
CONCLUSIONS: Real-world data demonstrate favourable clinical and safety outcomes of filgotinib for UC.PMID:38494867 | DOI:10.1111/apt.17961 (Source: Herpes)
Source: Herpes - March 18, 2024 Category: Infectious Diseases Authors: Shintaro Akiyama Kaoru Yokoyama Soichi Yagi Shinichiro Shinzaki Kozo Tsuruta Shinichiro Yoshioka Minako Sako Hiromichi Shimizu Mariko Kobayashi Toshiyuki Sakurai Kei Nomura Tomoyoshi Shibuya Masahiro Takahara Sakiko Hiraoka Kyohei Sugai Shunichi Yanai Ats Source Type: research
The Chinese herbal prescription JZ-1 promotes extracellular vesicle production and protects against herpes simplex virus type 2 infection in vitro
CONCLUSION: JZ-1 had an anti-HSV-2 efficacy. After JZ-1 stimulation, VK2/E6E7 cells secreted extracellular vesicles which protect host cells from HSV-2 infection. High-throughput sequencing showed that these extracellular vesicles contained a large number of miRNAs targeting PI3K/AKT/mTOR pathway. JZ-1 group extracellular vesicles could inhibit the activation of AKT/mTOR pathway and induce the host cells autophagy.PMID:38495169 | PMC:PMC10940933 | DOI:10.1016/j.heliyon.2024.e27019 (Source: Herpes)
Source: Herpes - March 18, 2024 Category: Infectious Diseases Authors: Wenjia Wang Ximing Jin Qingqing Shao Tong Liu Tianli Liu Xinwei Zhao Lijun Xu Wen Gao Liu Hu Zhuo Chen Source Type: research
