Otologic disease trends in Japan post-COVID-19 outbreak: A retrospective time-series analysis
CONCLUSION: Our findings indicate that COVID-19 and vaccinations had minimal discernible effects on hospitalization of patients with otologic diseases, suggesting that otologic diseases may not be significantly impacted by COVID-19 and vaccinations, which could have implications for public health policies and the allocation of healthcare resources during a pandemic. Further research and monitoring of long-term effects are warranted to validate these findings and guide healthcare decision-making.PMID:38522357 | DOI:10.1016/j.anl.2024.01.004 (Source: Herpes)
Source: Herpes - March 24, 2024 Category: Infectious Diseases Authors: Keisuke Kondo Keiji Honda Keiichi Goshima Norihiko Inoue Daisuke Shinjo Takeshi Tsutsumi Kiyohide Fushimi Source Type: research
Otologic disease trends in Japan post-COVID-19 outbreak: A retrospective time-series analysis
CONCLUSION: Our findings indicate that COVID-19 and vaccinations had minimal discernible effects on hospitalization of patients with otologic diseases, suggesting that otologic diseases may not be significantly impacted by COVID-19 and vaccinations, which could have implications for public health policies and the allocation of healthcare resources during a pandemic. Further research and monitoring of long-term effects are warranted to validate these findings and guide healthcare decision-making.PMID:38522357 | DOI:10.1016/j.anl.2024.01.004 (Source: Herpes)
Source: Herpes - March 24, 2024 Category: Infectious Diseases Authors: Keisuke Kondo Keiji Honda Keiichi Goshima Norihiko Inoue Daisuke Shinjo Takeshi Tsutsumi Kiyohide Fushimi Source Type: research
Efficient scar-free knock-ins of several kilobases in plants by engineered CRISPR/Cas endonucleases
Mol Plant. 2024 Mar 22:S1674-2052(24)00086-8. doi: 10.1016/j.molp.2024.03.013. Online ahead of print.ABSTRACTIn plants and mammals, non-homologous end-joining is the dominant pathway to repair DNA double strand breaks, making it challenging to generate knock-in events. We identified two groups of exonucleases from the Herpes Virus and the bacteriophage T7 families that conferred an up to 38-fold increase in HDR frequencies when fused to Cas9/Cas12a in a Tobacco mosaic virus-based transient assay in Nicotiana benthamiana. We achieved precise and scar-free insertion of several kilobases of DNA both in transient and stable tr...
Source: Herpes - March 23, 2024 Category: Infectious Diseases Authors: Tom Schreiber Anja Prange Petra Sch äfer Thomas Iwen Ramona Gr ützner Sylvestre Marillonnet Aur élie Lepage Maire Javelle Wyatt Paul Alain Tissier Source Type: research
Psychoeducational interventions for people living with chronic communicable disease: a systematic review
CONCLUSION: The findings of this review highlight potential benefits of psychoeducation but indicate more robust clinical trials will be required to examine their effectiveness and elucidate the mechanisms by which they best operate. Future interventions incorporating a broader focus on resilience enhancement and coping skills specific to stigmatisation could more comprehensively serve the needs of adults living with chronic communicable disease, particularly with HIV. The role of peer support in group psychoeducation merits further exploration.PROSPERO REGISTRATION NUMBER: CRD42021243058.PMID:38521523 | DOI:10.1136/bmjope...
Source: Herpes - March 23, 2024 Category: Infectious Diseases Authors: Aoife Burke Martin P Davoren Ella Arensman Janas M Harrington Source Type: research
UVB induced reactivation leads to HSV1 in the corneas of virtually all latently infected mice and requires STING to develop corneal disease
Sci Rep. 2024 Mar 21;14(1):6859. doi: 10.1038/s41598-024-52597-0.ABSTRACTReactivation of latent herpes simplex type 1 results in virus returning to the cornea leading to recurrent herpetic stromal keratitis (rHSK). We compare two competing models to reactivate viruses from latency, UV-B irradiation and cyclophosphamide (CP). Results revealed that while both result in corneal recrudescence, only UV-B irradiation results in rHSK. To better understand the dynamics of reactivation, we analyzed corneas for both the presence of infectious viruses and the dynamics of exposure to multiple reactivations using UV-B. We noted that mu...
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Xiao-Tang Yin Alexis Hartman Nadia Sirajuddin Deepak Shukla Anthony St Leger Tammie L Keadle Patrick M Stuart Source Type: research
Navigating diagnostic challenges: imaging strategies for herpes simplex encephalitis in resource limited settings: A case report
Radiol Case Rep. 2024 Mar 13;19(6):2183-2187. doi: 10.1016/j.radcr.2024.02.060. eCollection 2024 Jun.ABSTRACTEncephalitis refers to the inflammatory condition affecting the brain parenchyma, leading to various neurological impairments. It can have various causes: infectious, postinfectious, and noninfectious origins. In this case, we present a 76-year-old man who presented to the emergency room with complaints of headache and behavioral changes. Initially, a Computed Tomography (CT) scan raised suspicion of herpes simplex encephalitis and prompted the initiation of treatment. Subsequently, Magnetic Resonance Imaging (MRI) ...
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Shimalis Tadasa Fayisa Nishma Pokharel Abisiniya Solomon Lense Negash Lidiya Ayele Biltibo Selamawit Hailu Bedasso Abel Tsehay Abebe Source Type: research
Expanded spectrum of varicella disease and the need for vaccination in India
Hum Vaccin Immunother. 2024 Dec 31;20(1):2328955. doi: 10.1080/21645515.2024.2328955. Epub 2024 Mar 22.ABSTRACTVaricella vaccine was first licensed in Japan and South Korea in 1989 for use in healthy children and was introduced in US in 1995. So far, 29 countries have adopted varicella vaccine in their universal immunization program (UIP). No Asian country, India included, has adopted the varicella vaccine as part of their UIP. The extra-cutaneous sites for VZV diseases are central nervous system and gastrointestinal tract, the expanded disease spectrum includes vasculopathy, myelitis, inflammatory bowel disease, perforate...
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Padma Srikanth Ilakkiya Arumugam Seetha N Jeganathan Rithvik Ramesh Lakshmi Narasimhan Ranganathan Shanthi Vijayaraghavan Source Type: research
Viral Anterior Uveitis: Differences in Retinal Vessel Area Density between the Affected and Non-Affected Eye Using Optical Coherence Tomography Angiography
CONCLUSION: We observed vascular dysfunction characterized by decreased macular and peripapillary VAD in the superficial plexus on OCTA in eyes with HSV- and VZV-positive VAU compared to non-affected fellow eyes. These changes might be an early sign of glaucomatous damage or may be a direct consequence of the herpes viruses themselves.PMID:38517389 | DOI:10.1080/09273948.2024.2329318 (Source: Herpes)
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Anna-Karina B Maier Daniel Mandrossa Emanuel Reitemeyer Sibylle Winterhalter Anne R übsam Uwe Pleyer Source Type: research
UVB induced reactivation leads to HSV1 in the corneas of virtually all latently infected mice and requires STING to develop corneal disease
Sci Rep. 2024 Mar 21;14(1):6859. doi: 10.1038/s41598-024-52597-0.ABSTRACTReactivation of latent herpes simplex type 1 results in virus returning to the cornea leading to recurrent herpetic stromal keratitis (rHSK). We compare two competing models to reactivate viruses from latency, UV-B irradiation and cyclophosphamide (CP). Results revealed that while both result in corneal recrudescence, only UV-B irradiation results in rHSK. To better understand the dynamics of reactivation, we analyzed corneas for both the presence of infectious viruses and the dynamics of exposure to multiple reactivations using UV-B. We noted that mu...
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Xiao-Tang Yin Alexis Hartman Nadia Sirajuddin Deepak Shukla Anthony St Leger Tammie L Keadle Patrick M Stuart Source Type: research
Navigating diagnostic challenges: imaging strategies for herpes simplex encephalitis in resource limited settings: A case report
Radiol Case Rep. 2024 Mar 13;19(6):2183-2187. doi: 10.1016/j.radcr.2024.02.060. eCollection 2024 Jun.ABSTRACTEncephalitis refers to the inflammatory condition affecting the brain parenchyma, leading to various neurological impairments. It can have various causes: infectious, postinfectious, and noninfectious origins. In this case, we present a 76-year-old man who presented to the emergency room with complaints of headache and behavioral changes. Initially, a Computed Tomography (CT) scan raised suspicion of herpes simplex encephalitis and prompted the initiation of treatment. Subsequently, Magnetic Resonance Imaging (MRI) ...
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Shimalis Tadasa Fayisa Nishma Pokharel Abisiniya Solomon Lense Negash Lidiya Ayele Biltibo Selamawit Hailu Bedasso Abel Tsehay Abebe Source Type: research
Expanded spectrum of varicella disease and the need for vaccination in India
Hum Vaccin Immunother. 2024 Dec 31;20(1):2328955. doi: 10.1080/21645515.2024.2328955. Epub 2024 Mar 22.ABSTRACTVaricella vaccine was first licensed in Japan and South Korea in 1989 for use in healthy children and was introduced in US in 1995. So far, 29 countries have adopted varicella vaccine in their universal immunization program (UIP). No Asian country, India included, has adopted the varicella vaccine as part of their UIP. The extra-cutaneous sites for VZV diseases are central nervous system and gastrointestinal tract, the expanded disease spectrum includes vasculopathy, myelitis, inflammatory bowel disease, perforate...
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Padma Srikanth Ilakkiya Arumugam Seetha N Jeganathan Rithvik Ramesh Lakshmi Narasimhan Ranganathan Shanthi Vijayaraghavan Source Type: research
Viral Anterior Uveitis: Differences in Retinal Vessel Area Density between the Affected and Non-Affected Eye Using Optical Coherence Tomography Angiography
CONCLUSION: We observed vascular dysfunction characterized by decreased macular and peripapillary VAD in the superficial plexus on OCTA in eyes with HSV- and VZV-positive VAU compared to non-affected fellow eyes. These changes might be an early sign of glaucomatous damage or may be a direct consequence of the herpes viruses themselves.PMID:38517389 | DOI:10.1080/09273948.2024.2329318 (Source: Herpes)
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Anna-Karina B Maier Daniel Mandrossa Emanuel Reitemeyer Sibylle Winterhalter Anne R übsam Uwe Pleyer Source Type: research
UVB induced reactivation leads to HSV1 in the corneas of virtually all latently infected mice and requires STING to develop corneal disease
Sci Rep. 2024 Mar 21;14(1):6859. doi: 10.1038/s41598-024-52597-0.ABSTRACTReactivation of latent herpes simplex type 1 results in virus returning to the cornea leading to recurrent herpetic stromal keratitis (rHSK). We compare two competing models to reactivate viruses from latency, UV-B irradiation and cyclophosphamide (CP). Results revealed that while both result in corneal recrudescence, only UV-B irradiation results in rHSK. To better understand the dynamics of reactivation, we analyzed corneas for both the presence of infectious viruses and the dynamics of exposure to multiple reactivations using UV-B. We noted that mu...
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Xiao-Tang Yin Alexis Hartman Nadia Sirajuddin Deepak Shukla Anthony St Leger Tammie L Keadle Patrick M Stuart Source Type: research
Navigating diagnostic challenges: imaging strategies for herpes simplex encephalitis in resource limited settings: A case report
Radiol Case Rep. 2024 Mar 13;19(6):2183-2187. doi: 10.1016/j.radcr.2024.02.060. eCollection 2024 Jun.ABSTRACTEncephalitis refers to the inflammatory condition affecting the brain parenchyma, leading to various neurological impairments. It can have various causes: infectious, postinfectious, and noninfectious origins. In this case, we present a 76-year-old man who presented to the emergency room with complaints of headache and behavioral changes. Initially, a Computed Tomography (CT) scan raised suspicion of herpes simplex encephalitis and prompted the initiation of treatment. Subsequently, Magnetic Resonance Imaging (MRI) ...
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Shimalis Tadasa Fayisa Nishma Pokharel Abisiniya Solomon Lense Negash Lidiya Ayele Biltibo Selamawit Hailu Bedasso Abel Tsehay Abebe Source Type: research
Immune response to the recombinant herpes zoster vaccine in people living with HIV over 50 years of age compared to non-HIV age-/gender-matched controls (SHINGR'HIV): a multicenter, international, non-randomized clinical trial study protocol
DISCUSSION: The SHINGR'HIV trial will provide robust data on the immunogenicity and safety profile of RZV in older PLWH to support vaccination guidelines in this population.TRIAL REGISTRATION: ClinicalTrials.gov NCT05575830. Registered on 12 October 2022. Eu Clinical Trial Register (EUCT number 2023-504482-23-00).PMID:38504173 | DOI:10.1186/s12879-024-09192-5 (Source: Herpes)
Source: Herpes - March 20, 2024 Category: Infectious Diseases Authors: Maxime Hentzien Fabrice Bonnet Enos Bernasconi Emmanuel Biver Dominique L Braun Aline Munting Karoline Leuzinger Olivier Leleux Stefano Musardo Virginie Prendki Patrick Schmid Cornelia Staehelin Marcel Stoeckle Carla S Walti Linda Wittkop Victor Appay Arn Source Type: research
