Retraction Note to: EV71 virus reduces Nrf2 activation to promote production of reactive oxygen species in infected cells
(Source: Gut Pathogens)
Source: Gut Pathogens - November 28, 2023 Category: Microbiology Source Type: research
Pathogenetic detection, retrospective and pathogenicity analysis of a fatal case of Vibrio vulnificus in Shenzhen, China
We report a 36-year-old male patient died ofV. vulnificus-induced septicaemia and multiple organ failure syndrome after oyster consumption at a restaurant. We isolated and identifiedV. vulnificus vv16015 from the patient ’s blood sample and antibiotic susceptibility tests indicated sensitivity to all 21 antibiotics. Oyster samples were subsequently collected from the restaurant’s supplier and three strains ofV. vulnificus were isolated. Whole genome sequencing and analysis revealed vv16015 to be distantly related to these strains and confirmed thatV. vulnificus contamination was present in the seafood of the restaurant...
Source: Gut Pathogens - November 25, 2023 Category: Microbiology Source Type: research
1H-NMR based-metabolomics reveals alterations in the metabolite profiles of chickens infected with ascarids and concurrent histomonosis infection
ConclusionIn conclusion,1H-NMR based-metabolomics revealed significant alterations in the plasma metabolome of high performing chickens infected with gut pathogens —A. galli andH. gallinarum. The alterations suggested upregulation of key metabolic pathways mainly during the patency of infections. This approach extends our understanding of host interactions with gastrointestinal nematodes at the metabolic level. (Source: Gut Pathogens)
Source: Gut Pathogens - November 17, 2023 Category: Microbiology Source Type: research
Strain-resolved metagenomic analysis of the gut as a reservoir for bloodstream infection pathogens among premature infants in Singapore
ConclusionsAntibiotic exposures were the dominant modifiable factor affecting gut microbiota composition in a large cohort of premature infants from South-East Asia. Strain-resolved analyses indicate that the gut is an important reservoir for organisms causing BSI among premature infants. (Source: Gut Pathogens)
Source: Gut Pathogens - November 16, 2023 Category: Microbiology Source Type: research
Correlation between gut microbiota composition, enteric infections and linear growth impairment: a case –control study in childhood stunting in Pidie, Aceh, Indonesia
ConclusionThe present study showed the distinctive gut microbiome profile of stunted and normal children from Pidie, Aceh, Indonesia. The gut microbiota of stunted children revealed dysbiosis, comprised several pro-inflammatory, metabolic abnormalities and high-fat/low-fiber diet-related taxa, and expressed virulence genes of enteric pathogens. These findings provide evidence that it is imperative to restore dysbiosis and preserve the balance of gut microbiota to support linear growth in children. (Source: Gut Pathogens)
Source: Gut Pathogens - November 9, 2023 Category: Microbiology Source Type: research
The immune-adjunctive potential of recombinant LAB vector expressing murine IFN λ3 (MuIFNλ3) against Type A Influenza Virus (IAV) infection
ConclusionSince the primary target for IAV infections is the upper respiratory and gastrointestinal tract, immune activation without affecting the tissue homeostasis suggests the immune-adjunctive potential of IFN λ3 against IAV infections. (Source: Gut Pathogens)
Source: Gut Pathogens - October 30, 2023 Category: Microbiology Source Type: research
Polymorphism of virulence genes and biofilm associated with in vitro induced resistance to clarithromycin in Helicobacter pylori
ConclusionsTherefore, this study suggests thatH. pylori may acquire virulence factors while also developing antibiotic resistance due to clarithromycin exposure. (Source: Gut Pathogens)
Source: Gut Pathogens - October 28, 2023 Category: Microbiology Source Type: research
Gut microbiota and autism spectrum disorders: where do we stand?
ConclusionsIn recent years, the study of gut microbiota and its association with ASD has garnered considerable interest as an emergent field of study. The results of this study substantially enhance our current understanding of the knowledge landscape in this field and illuminate potential avenues for future research. It is essential to emphasize the significance of devoting more resources to the newest and most promising research areas, such as investigating the potential therapeutic benefits of modulating the intestinal microbiota in children with ASD. This research has enormous potential and merits intensified focus and...
Source: Gut Pathogens - October 25, 2023 Category: Microbiology Source Type: research
Severe asthma patient with secondary Citrobacter koseri abdominal infection: first case report and review of the literature
AbstractCitrobacter koseri (C. koseri) is a Gram-negative, motile, non-spore-forming facultative anaerobic bacillus belonging to theEnterobacteriaceae family.C. koseri typically utilizes citrate as the sole carbon source and constitutes part of the normal gastrointestinal flora in humans and animals. As an opportunistic pathogen,C. koseri infections are mainly observed in neonates, elderly individuals, and immunocompromised hosts.C. koseri has been one of the main etiological agents of neonatal meningitis and cerebral abscess. In recent years, an increasing number of cases have been reported in adults with severe infection...
Source: Gut Pathogens - October 25, 2023 Category: Microbiology Source Type: research
Investigating the effect of the inhibitory peptide on L.monocytogenes cell invasion: an in silico and in vitro study
ConclusionThese results reveal that short polypeptides can impede the invasion of target cells byL. monocytogenes in vitro and could be advantageous as restoring agents in vivo. (Source: Gut Pathogens)
Source: Gut Pathogens - October 25, 2023 Category: Microbiology Source Type: research
miR-125a-5p regulates the sialyltransferase ST3GAL1 in murine model of human intestinal campylobacteriosis
ConclusionFrom our previous studies and the data presented here, we conclude that miR-125a-5p and the previously reported miR-615-3p are involved in regulating the glycosylation patterns of relevant host cell response proteins duringC. jejuni infection. The miRNA-dependent modulation of mucin-typeO-glycosylation could be part of the mucosal immune response, but also a pathogen-driven modification that allows colonisation and infection of the mammalian host. (Source: Gut Pathogens)
Source: Gut Pathogens - October 17, 2023 Category: Microbiology Source Type: research
Molecular characterization of Clostridium perfringens isolates from a tertiary children ’s hospital in Guangzhou, China, establishing an association between bacterial colonization and food allergies in infants
ConclusionsThis study demonstrates that intestinal colonization byClostridium perfringens is common in infants. The majority ofClostridium perfringens isolates are classified as type C. Colonization of the intestine byClostridium perfringens is associated with the development of CMPA and food allergy in infants. (Source: Gut Pathogens)
Source: Gut Pathogens - October 8, 2023 Category: Microbiology Source Type: research
Establishment of persistent enteric mycobacterial infection following streptomycin pre-treatment
AbstractMycobacterium avium subsp.paratuberculosis (MAP) is the causative agent of paratuberculosis, a chronic gastrointestinal disease affecting ruminants. This disease remains widespread in part due to the limitations of available diagnostics and vaccines. A representative small animal model of disease could act as a valuable tool for studying its pathogenesis and to develop new methods for paratuberculosis control, but current models are lacking. Streptomycin pre-treatment can reduce colonization resistance and has previously been shown to improve enteric infection in aSalmonella model. Here, we investigated whether str...
Source: Gut Pathogens - October 3, 2023 Category: Microbiology Source Type: research
A multi-omics study to investigate the progression of the Correa pathway in gastric mucosa in the context of cirrhosis
ConclusionsThe alterations in the gastric mucosal microbiome and transcriptome of LC patients were identified. The impaired energy metabolism in gastric mucosal cells and bile acids might aggravate the inflammation of gastric mucosa and even exacerbate the Correa ’s cascade process. The gastric mucosal cells might reduce bile acid toxicity by bile acid efflux and detoxification.Trial registration: ChiCTR2100051070. (Source: Gut Pathogens)
Source: Gut Pathogens - September 26, 2023 Category: Microbiology Source Type: research
Whole-genome characterization of common rotavirus strains circulating in Vellore, India from 2002 to 2017: emergence of non-classical genomic constellations
This study characterized the common circulating strains in Vellore, India from 2002 to 2017 to understand rotavirus strain diversity and evolution using Whole genome sequencing (WGS) carried out on Illumina MiSeq. The 89% (92% of Wa-like, 86% of DS-1-like) of strains had classical constellations, while reassortant constellations were seen in 11% (8% of Wa-like, 14% of DS-1-like) of the strains. The rare E6-NSP4 in combination with DS-1 like G1P[8] and the emergence of the OP-354 subtype of P[8] were identif ied. Phylogenetics of RV strains revealed multiple subtypes circulating in the past 15 years, with strong evidence ...
Source: Gut Pathogens - September 20, 2023 Category: Microbiology Source Type: research
