Molecular epidemiology of rotavirus A and adenovirus among children with acute diarrhea in Hangzhou, China
ConclusionsG9P[8] of RVA and Adv-41 were the most common genotypes that caused children ’s acute diarrhea in Hangzhou, 2017–2018. (Source: Gut Pathogens)
Source: Gut Pathogens - April 12, 2020 Category: Microbiology Source Type: research
Distribution of genes related to Type 6 secretion system and lipooligosaccharide that induced ganglioside mimicry among Campylobacter jejuni isolated from human diarrhea in Thailand
ConclusionsOur results suggested a high diversity ofhcp and GBS-associated LOS genes among capsule types ofC. jejuni isolated from Thailand. (Source: Gut Pathogens)
Source: Gut Pathogens - April 8, 2020 Category: Microbiology Source Type: research
Enteric etiological surveillance in acute diarrhea stool of United States Military Personnel on deployment in Thailand, 2013 –2017
ConclusionThe detection ofCampylobacter isolates with CIP, AZM and ERY resistance has critical force health protection and public health implications, as these data should guide effective Campylobacteriosis treatment options for deployed military members and travelers to Southeast Asia. Additional research efforts are recommended to determine the association of pathogen co-infections and/or other contributing factors towards diarrheal disease in military and traveler populations. Ongoing surveillance and AST profiling of potential disease-causing bacteria is required for effective disease prevention efforts and treatment s...
Source: Gut Pathogens - April 8, 2020 Category: Microbiology Source Type: research
Profound remission in Crohn ’s disease requiring no further treatment for 3–23 years: a case series
ConclusionsProlonged remission has been achieved for 3 –23 years with individualised treatments, with the majority using AMAT ± infliximab and FMT. Treatment with antibiotics and/or FMT provides a potential new avenue for treatment of CD. These findings should stimulate thinking, investigations and better therapy against MAP and the dysbiosis o f the gut flora, to enable higher rates of prolonged remission. (Source: Gut Pathogens)
Source: Gut Pathogens - April 8, 2020 Category: Microbiology Source Type: research
Proof-of-concept trial of the combination of lactitol with Bifidobacterium bifidum and Lactobacillus acidophilus for the eradication of intestinal OXA-48-producing Enterobacteriaceae
ConclusionsThe combination of prebiotics and probiotics was well tolerated. A rapid reduction on the OXA-PE intestinal loads was observed. At the EoT, decolonization was achieved in three patients.Clinical Trials Registration: NCT02307383. EudraCT Number: 2014-000449-65. (Source: Gut Pathogens)
Source: Gut Pathogens - April 6, 2020 Category: Microbiology Source Type: research
Association of antimicrobial resistance and gut microbiota composition in human and non-human primates at an urban ecotourism site
ConclusionHigher antibiotic susceptibility in NHPs is likely related to low direct exposure to antibiotics. The lack of resistance may also suggest limited antimicrobial resistance transmission between humans and NHP. Nonetheless, continued monitoring over a long period will help mitigate the risk of anthropozoonosis and zooanthroponosis. (Source: Gut Pathogens)
Source: Gut Pathogens - March 9, 2020 Category: Microbiology Source Type: research
Analyses of energy metabolism and stress defence provide insights into Campylobacter concisus growth and pathogenicity
In conclusion, this study provides a molecular basis for the non-saccharolytic and hydrogen-dependent nature ofC. concisus energy metabolism pathways, which provides insights into the growth requirements and pathogenicity of this species. (Source: Gut Pathogens)
Source: Gut Pathogens - March 4, 2020 Category: Microbiology Source Type: research
Complete genome of Enterobacter sichuanensis strain SGAir0282 isolated from air in Singapore
ConclusionBased on whole genome alignment and phylogenetic analysis, the strain SGAir0282 was identified to beEnterobacter sichuanensis. The strain possesses gene clusters for virulence, disease and defence, that can also be found in other multidrug resistant ECC type strains. (Source: Gut Pathogens)
Source: Gut Pathogens - February 26, 2020 Category: Microbiology Source Type: research
Gut microbiome of native Arab Kuwaitis
ConclusionsBacteroides was the most abundant genus in the gut microbiome of native Arab Kuwaiti adults, withBacteroides dorei/vulgatus forming the predominant phylogenetic group. The microbiome composition would also have been influenced by the nutritional status of participants. (Source: Gut Pathogens)
Source: Gut Pathogens - February 25, 2020 Category: Microbiology Source Type: research
Effects of co-infection on the clinical outcomes of Clostridium difficile infection
ConclusionOur study suggests that co-infection doesn ’t affect the severity of CDI or can cause treatment failures. Additionally, there was no significant increase in hospital stay, or increase in CDI recurrence associated with co-infection. Therefore, if CDI is the leading clinical diagnosis and a patient is tested positive for co-infection in addi tion to CDI on FilmArray® multiplex GI panel, this co-infection shouldn’t change the management for CDI. Limitations of this study (including retrospective nature of the study, small sample size, single site study, not including all microbiome and non-inclusion of race) sh...
Source: Gut Pathogens - February 24, 2020 Category: Microbiology Source Type: research
Campylobacter jejuni genes Cj1492c and Cj1507c are involved in host cell adhesion and invasion
ConclusionWe conclude that genes regulated by Cj1507c have an impact on efficient adhesion, invasion and intracellular survival ofC. jejuni in HT-29/B6 cells. Furthermore, potential signal sensing by Cj1492c seems to lead to limiting attachment and hence internalisation ofC. jejuni. However, as the intracellular survival capacities are reduced, we suggest that signal sensing by Cj1492c impacts several processes related to pathogenicity ofC. jejuni. (Source: Gut Pathogens)
Source: Gut Pathogens - February 10, 2020 Category: Microbiology Source Type: research
Gut microbiota changes in children with autism spectrum disorder: a systematic review
ConclusionsThese results were inadequate to confirm a global microbiome change in children with ASD and causality could not be inferred to explain the etiology of the behaviors associated with ASD. Mechanistic studies are needed to elucidate the specific role of the gut microbiome in the pathogenesis of ASD. (Source: Gut Pathogens)
Source: Gut Pathogens - February 2, 2020 Category: Microbiology Source Type: research
Colistin-resistant Escherichia coli carrying mcr-1 in food, water, hand rinse, and healthy human gut in Bangladesh
ConclusionWidespread dissemination ofE. coli strains carryingmcr-1 encoding resistance to colistin in the present study is alarming as this is the last resort drug for the treatment of infections caused by MDR gram-negative bacteria resistant to almost all drugs used commonly. (Source: Gut Pathogens)
Source: Gut Pathogens - January 26, 2020 Category: Microbiology Source Type: research
Phenotypic zinc resistance does not correlate with antimicrobial multi-resistance in fecal E. coli isolates of piglets
ConclusionOur findings argue against a co-selection mechanism of antimicrobial drug-resistance and zinc tolerance after dietary zinc supplementation in weaning piglets. An explanation for an increase in multi-drug resistant isolates from piglets with high zinc dietary feeding could be that resistant bacteria to antimicrobial agents are more persistent to stresses such as zinc or copper exposure. (Source: Gut Pathogens)
Source: Gut Pathogens - January 20, 2020 Category: Microbiology Source Type: research
Carvacrol ameliorates acute campylobacteriosis in a clinical murine infection model
ConclusionThe loweredC. jejuni loads and alleviated symptoms observed in the here applied clinical murine model for human campylobacteriosis highlight the application of carvacrol as a promising novel option for both, the treatment of campylobacteriosis and hence, for prevention of post-infectious sequelae in humans, and for the reduction ofC. jejuni colonization in the intestines of vertebrate lifestock animals. (Source: Gut Pathogens)
Source: Gut Pathogens - January 7, 2020 Category: Microbiology Source Type: research
