A re-testing range is recommended for 13C- and 14C-urea breath tests for Helicobacter pylori infection in China
ConclusionsThe establishment of an indeterminate range is recommended to allow for repeated testing to confirmH. pylori infection, and thereby avoiding unnecessary antibiotic treatment.Trial registration: Chinese Clinical Trial Registry, ChiCTR2000041570. Registered 29 December 2020- Retrospectively registered,http://www.chictr.org.cn/edit.aspx?pid=66416&htm=4 (Source: Gut Pathogens)
Source: Gut Pathogens - June 12, 2021 Category: Microbiology Source Type: research
Mixtures of natural antimicrobials can reduce Campylobacter jejuni, Salmonella enterica and Clostridium perfringens infections and cellular inflammatory response in MDCK cells
ConclusionThe present study describes for the first time that mixtures of natural antimicrobials can prevent the formation of substrates used by bacterial pathogens to grow and survive in anaerobic environments (e.g. tetrathionate). Moreover, we provide further insights into pathogen invasion mechanisms through restoration of cellular structures and describe their ability to block the ERK –MAPK kinase pathway responsible for inflammatory cytokine release (Source: Gut Pathogens)
Source: Gut Pathogens - June 7, 2021 Category: Microbiology Source Type: research
Helicobacter pylori in the Indonesian Malay ’s descendants might be imported from other ethnicities
ConclusionsEven though the ethnic groups live together as a community, we observed an extremely lowH. pylori infection rate among Indonesian Malay descendants with no specific Indonesian MalayH. pylori. The results suggest thatH. pylori was not originally among these groups andH. pylori was imported from other ethnic groups. (Source: Gut Pathogens)
Source: Gut Pathogens - June 4, 2021 Category: Microbiology Source Type: research
Presence of plasmid-mediated quinolone resistance (PMQR) genes in non-typhoidal Salmonella strains with reduced susceptibility to fluoroquinolones isolated from human salmonellosis in Gyeonggi-do, South Korea from 2016 to 2019
In conclusion,qnr gene-positiveSalmonella 4,[5],12:i:- andSalmonella Typhimurium were the main serovars responsible for reduced susceptibility to fluoroquinolones. Therefore, our findings suggest that PMQR-positiveSalmonella strains, which can be isolated from various samples including human, food, and the environment, should be carefully monitored. (Source: Gut Pathogens)
Source: Gut Pathogens - June 1, 2021 Category: Microbiology Source Type: research
Evolution of the GII.3[P12] Norovirus from 2010 to 2019 in Jiangsu, China
ConclusionsWe conducted a comprehensive analysis on the epidemic and evolution of GII.3[P12] noroviruses and the results suggested that evolution was possibly driven by intergenic recombination and mutations in some key amino acid sites. (Source: Gut Pathogens)
Source: Gut Pathogens - May 26, 2021 Category: Microbiology Source Type: research
Burden and etiology of moderate and severe diarrhea in children less than 5 years of age living in north and south of China: Prospective, population-based surveillance
ConclusionOur study demonstrated high diversity and prevalence of multiple major bacterial and viral agents, including rotavirus and calicivirus, among children in China. Further studies are needed to define the public health significance of neglected but frequently detected pathogens such as EAEC, enterotoxigenicE. coli,Campylobacter, adenovirus, and enterovirus. (Source: Gut Pathogens)
Source: Gut Pathogens - May 24, 2021 Category: Microbiology Source Type: research
The prevalence of the iutA and ibeA genes in Escherichia coli isolates from severe and non-severe patients with bacteremic acute biliary tract infection is significantly different
ConclusionsWe showed that bacteremicE. coli strains from acute biliary tract infections belonged to the virulent (B2) phylogroup. The prevalence of theiutA andibeA genes between the two groups of bacteremia severity was significantly different. (Source: Gut Pathogens)
Source: Gut Pathogens - May 18, 2021 Category: Microbiology Source Type: research
The role of mycobiota-genotype association in inflammatory bowel diseases: a narrative review
AbstractInflammatory bowel disease (IBD) is a chronic inflammatory disease affecting various parts of the gastrointestinal tract. A majority of the current evidence points out the involvement of intestinal dysbiosis in the IBD pathogenesis. Recently, the association of intestinal fungal composition With IBD susceptibility and severity has been reported. These studies suggested gene polymorphisms in the front line of host defense against intestinal microorganisms are considered to play a role in IBD pathogenesis. The studies have also detected increased susceptibility to fungal infections in patients carrying IBD-related mu...
Source: Gut Pathogens - May 8, 2021 Category: Microbiology Source Type: research
Comparison of a mycobacterial phage assay to detect viable Mycobacterium avium subspecies paratuberculosis with standard diagnostic modalities in cattle with naturally infected Johne disease
ConclusionsIn contrast to our hypothesis, using the phage/qPCR assay we find that viable circulating MAP can rapidly be detected from the blood of animals infected with, as well as those in the Control group evidently colonized by MAP. These data indicate that the presence of viable MAP in blood does not necessarily signify that an animal must of necessity be demonstrably ill or be MAP positive by standard diagnostic methods. (Source: Gut Pathogens)
Source: Gut Pathogens - May 6, 2021 Category: Microbiology Source Type: research
Role of interferon gamma in SARS-CoV-2-positive patients with parasitic infections
ConclusionThe remarkable adaptation of human immune response to COVID-19 infection by parasitic infections with high levels of IFN- γ was observed in moderate cases compared with low levels in extreme cases. The potential therapeutic efforts aimed at the role of parasitic infection in immune system modulation are needed if this hypothesis is confirmed. (Source: Gut Pathogens)
Source: Gut Pathogens - May 4, 2021 Category: Microbiology Source Type: research
Intestinal parasites among intellectually disabled individuals in Iran: a systematic review and meta-analysis
ConclusionIPIs are highly prevalent among intellectually disabled individuals in Iran. Improving the health status and implementing infectious disease prevention strategies in rehabilitation centers, health promotion interventions to improve personal hygiene of intellectually disabled individuals, as well as utilize sensitive diagnostic methods besides routine stool examination techniques, and treatment of infected individuals will help in the control of these infections among intellectually disabled individuals. (Source: Gut Pathogens)
Source: Gut Pathogens - May 1, 2021 Category: Microbiology Source Type: research
Insights about the epidemiology of Salmonella Typhimurium isolates from different sources in Brazil using comparative genomics
ConclusionsThe phylogenetic trees grouped the majority of theS. Typhimurium isolates from humans into a single cluster suggesting that there is one prevalent subtype in Brazil. Regarding strains isolated from food and swine, the SNPs ’ results suggested the circulation of more than one subtype over 30 years in this country. The orthologous protein clusters analysis revealed unique genes in the strains studied mainly related to bacterial metabolism.S. Typhimurium strains from swine showed greater diversity of STs and prophages in comparison to strains isolated from humans and foods. The pathogenic potential ofS. Typhimuri...
Source: Gut Pathogens - April 28, 2021 Category: Microbiology Source Type: research
Helicobacter cinaedi bacteraemia secondary to enterocolitis in an immunocompetent patient
ConclusionsIn conclusion, this case ofH. cinaedi bacteraemia secondary to enterocolitis in an immunocompetent patient provide clear evidence that one route of infection occurs through translocation from the intestinal tract to the bloodstream.Helicobacter cinaedi from blood and faeces were identical with a novel ST20, resistant to ciprofloxacin and clarithromycin however, the patient was cured with oral pivampicillin. (Source: Gut Pathogens)
Source: Gut Pathogens - April 23, 2021 Category: Microbiology Source Type: research
Association of small intestinal bacterial overgrowth with Parkinson ’s disease: a systematic review and meta-analysis
ConclusionIn conclusion, our meta-analysis found a strong association between SIBO and PD with approximately half of PD patients testing positive for SIBO. These relationships significantly differed based on diagnostic test and geographic area. (Source: Gut Pathogens)
Source: Gut Pathogens - April 16, 2021 Category: Microbiology Source Type: research
Cytomegalovirus ‐associated esophagitis on early esophageal cancer in immunocompetent host: a case report
ConclusionsThis is the first report of a case of CMV esophagitis superimposed on early esophageal cancer in an immunocompetent host and might provide valuable information for possible adverse effects of steroid administration during ESD procedures, despite their common use for prevention of post-ESD stricture. (Source: Gut Pathogens)
Source: Gut Pathogens - April 16, 2021 Category: Microbiology Source Type: research
