The benefit of the bismuth add-on to the 2-week clarithromycin-based triple regimen for Helicobacter pylori eradication: a propensity score-matched retrospective study
ConclusionThe bismuth add-on to the 2-week clarithromycin-based triple regimen increased the eradication success rate. (Source: Gut Pathogens)
Source: Gut Pathogens - March 19, 2023 Category: Microbiology Source Type: research
Gut colonization with vancomicyn-resistant enterococci among patients with hematologic malignancies
ConclusionsOur results showed that 15.1% of patients with hematologic malignancies were colonized with VRE. There was a distinct prevalence of vanC enterococci. Among the analyzed risk factors, advanced age and multiple myeloma contributed to VRE acquisition. (Source: Gut Pathogens)
Source: Gut Pathogens - March 9, 2023 Category: Microbiology Source Type: research
Potential antiviral activities of chrysin against hepatitis B virus
ConclusionsThe outcome of our study establishes chrysin as a new antiviral against HBV infection. However, using chrysin to treat chronic HBV disease needs further endorsement and optimization by in vivo studies in animal models.Graphical Abstract (Source: Gut Pathogens)
Source: Gut Pathogens - March 9, 2023 Category: Microbiology Source Type: research
In-silico computational approaches to study microbiota impacts on diseases and pharmacotherapy
AbstractMicroorganisms have been linked to a variety of critical human disease, thanks to advances in sequencing technology and microbiology. The growing recognition of human microbe –disease relationships provides crucial insights into the underlying disease process from the perspective of pathogens, which is extremely useful for pathogenesis research, early diagnosis, and precision medicine and therapy. Microbe-based analysis in terms of diseases and related drug discovery c an predict new connections/mechanisms and provide new concepts. These phenomena have been studied via various in-silico computational approaches. ...
Source: Gut Pathogens - March 7, 2023 Category: Microbiology Source Type: research
Effect of probiotic supplementation on gastrointestinal motility, inflammation, motor, non-motor symptoms and mental health in Parkinson ’s disease: a meta-analysis of randomized controlled trials
ConclusionProbiotic supplements may be suitable for improving the motor and non-motor symptoms of PD and reducing depression. Further research is warranted to determine the mechanism of action of probiotics and to determine the optimal treatment protocol. (Source: Gut Pathogens)
Source: Gut Pathogens - March 6, 2023 Category: Microbiology Source Type: research
Comparison of antimicrobial resistant Escherichia coli isolated from Irish commercial pig farms with and without zinc oxide and antimicrobial usage
ConclusionsThe results of this study showed evidence that antimicrobial and ZnO treatment of pigs post-weaning can favour the selection and development of AMR and MDRE. coli. Co-location of resistance genes on mobile genetic elements was observed. This study demonstrated the usefulness of phenotypic and genotypic detection of antimicrobial resistance by combining sequencing and microbiological methods. (Source: Gut Pathogens)
Source: Gut Pathogens - February 24, 2023 Category: Microbiology Source Type: research
Development and evaluation of a simple PCR assay and nested PCR for rapid detection of clarithromycin-resistant Helicobacter pylori from culture and directly from the biopsy samples in India
ConclusionThis assay outlines a rapid, sensitive and simple approach to identify point mutation that confers clarithromycin resistance as well as clarithromycin sensitive strains, providing rapid initiation of effective antibiotic treatment. Additionally, it is simple to adopt for hospital based diagnostic laboratories to evaluate the degree of regional clarithromycin resistance from biopsy specimens itself. Furthermore, in silico studies provide evidence or a signal that the prevalence of clarithromycin resistance may rise in the near future as a result of this point mutation. (Source: Gut Pathogens)
Source: Gut Pathogens - February 14, 2023 Category: Microbiology Source Type: research
CMTM3 protects the gastric epithelial cells from apoptosis and promotes IL-8 by stabilizing NEMO during Helicobacter pylori infection
ConclusionsCMTM3 reduces apoptosis and promotes IL-8 expression in the gastric epithelial cells by stabilizing NEMO duringH. pylori infection. These findings characterize a new role for CMTM3 in host –pathogen interactions and provide novel insight into the molecular regulation of NEMO. (Source: Gut Pathogens)
Source: Gut Pathogens - February 13, 2023 Category: Microbiology Source Type: research
Campylobacter concisus from chronic inflammatory bowel diseases stimulates IL-8 production in HT-29 cells
AbstractThe emerging pathogenCampylobacter concisus has been isolated from patients with gastrointestinal diseases; however, it is also present in the gut of healthy individuals. The aim of this study was to compare IL-8 production in HT-29 cells after infection withC. concisus from different gastrointestinal disease phenotypes. Additionally, to investigate whether differentiation of isolates in genomospecies (GS1 and GS2) or presence of thezot gene, encoding the Zot toxin, affects IL-8 production. A total of 37C. concisus isolates from patients with microscopic colitis (n  = 20), ulcerative colitis (n = 5), Crohnâ...
Source: Gut Pathogens - February 13, 2023 Category: Microbiology Source Type: research
Invasion of intestinal cells by Staphylococcus warneri, a member of the human gut microbiota
AbstractCoagulase negative staphylococci (CoNS) are a heterogeneous group of bacteria that colonize different types of human epithelia. These bacteria have a highly variable pathogenic potential ranging from avirulent species to major nosocomial pathogens.Staphylococcus warneri is a CoNS species considered to be nonpathogenic. Here, we identify thatS. warneri is a natural member of both human and mouse gut microbiota. In addition, we demonstrate that this bacterium is able to get internalized into human cells. We show thatS. warneri efficiently invades several human cell types and, more specifically, intestinal epithelial ...
Source: Gut Pathogens - January 27, 2023 Category: Microbiology Source Type: research
Development of the gut microbiota during early life in premature and term infants
ConclusionsThe faecal microbiota differs greatly between infants born at term and those born prematurely during early life, yet it converges over time. Despite this, early clinical factors remain significantly associated with the abundance of some bacterial groups at 2 Â years of age. Given the associations made between health conditions and the microbiota, factors that alter the makeup of the gut microbiota, and potentially its trajectory through life, could have important lifelong consequences. (Source: Gut Pathogens)
Source: Gut Pathogens - January 16, 2023 Category: Microbiology Source Type: research
Virulence factors and mechanisms of paediatric pneumonia caused by Enterococcus faecalis
In conclusion, our findings demonstrate that the LTA of pathogenicE. faecalis in the intestine is a virulence factor that can cause paediatric pneumonia. This study found that intestinal bacterial virulence factors can induce immune responses in the lungs and blood. These findings could provide further insight into the mechanism of infectious diseases in the lung that are caused by bacteria in the intestine. (Source: Gut Pathogens)
Source: Gut Pathogens - January 9, 2023 Category: Microbiology Source Type: research
Study of microencapsulated fatty acid antimicrobial activity in vitro and its prevention ability of Clostridium perfringens induced necrotic enteritis in broiler chicken
ConclusionsThis finding indicated that dietary microencapsulated C12 –C14 and C10–C12 could inhibit the growth ofC. perfringens in chickens, which proves is viability to serve as an alternative to antibiotics used for necrotic enteritis caused byC. perfringens. (Source: Gut Pathogens)
Source: Gut Pathogens - January 2, 2023 Category: Microbiology Source Type: research
Prevalence of pks  + bacteria and enterotoxigenic Bacteroides fragilis in patients with colorectal cancer
ConclusionsHealthy controls had similar levels ofpks + bacteria and ETBF colonization as CRC patients, and their elevated levels may place both groups at greater risk of developing CRC. Colonization withpks + bacteria was less prevalent in early-compared to late-onset CRC. (Source: Gut Pathogens)
Source: Gut Pathogens - December 28, 2022 Category: Microbiology Source Type: research
Using whole-genome sequencing (WGS) to plot colorectal cancer-related gut microbiota in a population with varied geography
ConclusionPeptostreptococcus stomatis is a common high-risk pathogen of CRC worldwide, and it is an important variable in CRC risk prediction models in all regions. However, regional differences in intestinal bacteria had no significant impact on the accuracy of the CRC risk prediction model. (Source: Gut Pathogens)
Source: Gut Pathogens - December 28, 2022 Category: Microbiology Source Type: research
