Clinical manifestations, risk factors, and prognostic factors of cytomegalovirus enteritis
ConclusionsPhysicians should pay attention to the characteristics of CMV enteritis in high-risk patients to make an early diagnosis and potentially improve the clinical outcome. (Source: Gut Pathogens)
Source: Gut Pathogens - August 18, 2021 Category: Microbiology Source Type: research
Dock2 affects the host susceptibility to Citrobacter rodentium infection through regulating gut microbiota
ConclusionsThese results suggest that Dock2 regulates the composition of gut microbiota and affects the host susceptibility toC. rodentium infection. (Source: Gut Pathogens)
Source: Gut Pathogens - August 14, 2021 Category: Microbiology Source Type: research
Microbiome diversity declines while distinct expansions of Th17, iNKT, and dendritic cell subpopulations emerge after anastomosis surgery
ConclusionsThis anastomotic study demonstrated a decrease in IEC TLR4 expression and microbiome diversity which then coincided with increased expansion of regulatory and pro-inflammatory immune cells and cytokines. Defining the anastomotic mucosal environment could help inform innovative therapeutics to target excessive pro-inflammatory invasion and microbiome imbalance. (Source: Gut Pathogens)
Source: Gut Pathogens - August 10, 2021 Category: Microbiology Source Type: research
Gut microbiota influence in type 2 diabetes mellitus (T2DM)
AbstractA strong and expanding evidence base supports the influence of gut microbiota in human metabolism. Altered glucose homeostasis is associated with altered gut microbiota, and is clearly associated with the development of type 2 diabetes mellitus (T2DM) and associated complications. Understanding the causal association between gut microbiota and metabolic risk has the potential role of identifying susceptible individuals to allow early targeted intervention. (Source: Gut Pathogens)
Source: Gut Pathogens - August 6, 2021 Category: Microbiology Source Type: research
Effect of intestinal microecology on postnatal weight gain in very preterm infants in intensive care units
ConclusionIntestinal microecology is different between infants with EUGR and those with normal growth. The diversity and richness of the intestinal microflora in preterm infants at the NICU are significantly insufficient and change dynamically with time, and the establishment of intestinal homeostasis is obviously delayed. (Source: Gut Pathogens)
Source: Gut Pathogens - August 2, 2021 Category: Microbiology Source Type: research
Bioengineering of LAB vector expressing Haemolysin co-regulated protein (Hcp): a strategic approach to control gut colonization of Campylobacter jejuni in a murine model
ConclusionTogether with the non-commensal nature ofL. lactis, short gut transit time in humans, and the ability to express the heterologous protein in the gut, the present study highlights the benefits of bioengineered LAB vectors based mucosal vaccine modality againstC. jejuni without the risk of immunotolerance. (Source: Gut Pathogens)
Source: Gut Pathogens - July 30, 2021 Category: Microbiology Source Type: research
One health pathogen surveillance demonstrated the dissemination of gut pathogens within the two coastal regions associated with intensive farming
ConclusionsIn conclusion, our results demonstrated that intensive shrimp farming in wetlands has two devastating impacts: pathogen dissemination from aquatic animals into migratory birds and transmission of foodborne pathogens into local communities. (Source: Gut Pathogens)
Source: Gut Pathogens - July 23, 2021 Category: Microbiology Source Type: research
In silico molecular docking and in vitro antimicrobial efficacy of phytochemicals against multi-drug-resistant enteroaggregative Escherichia coli and non-typhoidal Salmonella spp.
ConclusionsIn silico molecular docking studies provided useful insights to understand the interaction of phytochemical ligands with protein motifs of pathogen and should be used routinely before the wet screening of any phytochemicals for their antibacterial, stability, and safety aspects. (Source: Gut Pathogens)
Source: Gut Pathogens - July 17, 2021 Category: Microbiology Source Type: research
Antibiotic resistance and detection of plasmid mediated colistin resistance mcr-1 gene among Escherichia coli and Klebsiella pneumoniae isolated from clinical samples
ConclusionHigh prevalence of drug-resistance in our study is indicative of a deteriorating situation of AMR. Moreover, significant prevalence of resistant enzymes in our study reinforces their roles in the emergence of drug resistance. Resistance to last resort drug (colistin) and the isolation ofmcr-1 indicate further urgency in infection management. Therefore, extensive surveillance, formulation and implementation of effective policies, augmentation of diagnostic facilities and incorporation of antibiotic stewardship programs can be some remedies to cope with this global crisis. (Source: Gut Pathogens)
Source: Gut Pathogens - July 5, 2021 Category: Microbiology Source Type: research
Deepoxy-deoxynivalenol (DOM-1), a derivate of deoxynivalenol (DON), exhibits less toxicity on intestinal barrier function, Campylobacter jejuni colonization and translocation in broiler chickens
ConclusionAltogether, the presence of DOM-1 in the feed as a result of the enzymatic biotransformation of DON leads to a lowerC. jejuni count in the intestine and better feed conversion ratio. Moreover, this study demonstrates that the detoxification product of DON, DOM-1, does not have negative effects on the gastrointestinal tract and reduces theCampylobacter burden in chickens and also the risk for human infection. (Source: Gut Pathogens)
Source: Gut Pathogens - July 3, 2021 Category: Microbiology Source Type: research
The penicillin binding protein 1A of Helicobacter pylori, its amoxicillin binding site and access routes
ConclusionsWe hypothesize that mutations in amino acid residues lining the binding site and/or tunnel-1, resulting in conformational/spatial changes, may block drug binding to PBP1A and cause AMX resistance. (Source: Gut Pathogens)
Source: Gut Pathogens - June 28, 2021 Category: Microbiology Source Type: research
The glycosyltransferase ST3GAL2 is regulated by miR-615-3p in the intestinal tract of Campylobacter jejuni infected mice
ConclusionsWe report here for the first time the regulation of glycosyltransferases by miRNAs during murine infection withC. jejuni 81-176. Our data suggest that mucin typeO-glycan biosynthesis is concerted by the interplay of miRNAs and glycosyltransferases, which could determine the shape of intestinal glycosylated proteins during infection. (Source: Gut Pathogens)
Source: Gut Pathogens - June 28, 2021 Category: Microbiology Source Type: research
Genomic analysis of halophilic bacterium, Lentibacillus sp. CBA3610, derived from human feces
ConclusionsStrain CBA3610 is predicted to be a novel candidate species ofLentibacillus through phylogenetic analysis and comparative genomic analysis with other species in the same genus. This strain has antibiotic resistance gene and pathogenic genes. In future, the information derived from the results of several genomic analyses of this strain is thought to be helpful in identifying the relationship between halophilic bacteria and human gut microbiota. (Source: Gut Pathogens)
Source: Gut Pathogens - June 23, 2021 Category: Microbiology Source Type: research
Virulence among different types of hypervirulent Klebsiella pneumoniae with multi-locus sequence type (MLST)-11, Serotype K1 or K2 strains
ConclusionSince there was a significant difference in virulence levels between the two types of HvKp when assessed in in vitro and in vivo models, it may be better to use the designation"HvKp" for some strains based on animal studies to avoid confusion. Virulence and non-virulence could be analysed in a relative manner, especially in comparison studies. (Source: Gut Pathogens)
Source: Gut Pathogens - June 22, 2021 Category: Microbiology Source Type: research
Geographic distribution of the cagA, vacA, iceA, oipA and dupA genes of Helicobacter pylori strains isolated in China
ConclusionsThere was significant geographic diversity ofH. pylori genotypes in different regions of China and the presence ofdupA gene can be considered as a marker for the development of gastroduodenal diseases. However, thecagA,iceA,vacA andoipA genes cannot be regarded for prediction of the clinical presentation ofH. pylori infection in China. (Source: Gut Pathogens)
Source: Gut Pathogens - June 15, 2021 Category: Microbiology Source Type: research
