Experimental induction of necrotic enteritis with or without predisposing factors using netB positive Clostridium perfringens strains
ConclusionsThis study suggests that virulentC. perfringens type G strains can induce NE lesions in the absence of other predisposing factors. Birds in the clostridia challenged group showed moderate to severe NE lesions. Use of less virulent coccidia strain contributed to a lesser extent in increasing the severity of disease. Maize based diet along with fishmeal (1:1) increased the severity of lesions but statistically it was non-significant. The NE lesions in all experimental groups were found to be present more frequently in the duodenum. In this way, this study provided an effective model for in vivo production of NE in...
Source: Gut Pathogens - November 17, 2021 Category: Microbiology Source Type: research
Detrimental relevance of Helicobacter pylori infection with sarcopenia
ConclusionsPositive serumH. pylori infectious markers including anti-H. pylori antibody and CagA seropositivity are correlated with sarcopenia and low muscle quantity. Therefore,H. pylori eradication therapy may bring benefits to sarcopenia patients with concurrent activeH. pylori infection. (Source: Gut Pathogens)
Source: Gut Pathogens - November 15, 2021 Category: Microbiology Source Type: research
Relationship between gut microbiome diversity and hepatitis B viral load in patients with chronic hepatitis B
ConclusionsThe gut microbiome in HBV-infected individuals with a low viral load is highly diverse and is dominated by specific taxa involved in fatty acid and lipid metabolism. To our knowledge, this is the first demonstration of a correlation between the presence of certain bacterial taxa and chronic HBV infection depending on the load of HBV DNA. (Source: Gut Pathogens)
Source: Gut Pathogens - October 30, 2021 Category: Microbiology Source Type: research
Hepatitis D: challenges in the estimation of true prevalence and laboratory diagnosis
AbstractHepatitis delta virus (HDV) is a defective single negative chain RNA virus, as its envelope protein synthesis is dependent on hepatitis B virus (HBV). Studies have consistently shown that coinfection of HBV and HDV is the most serious form of viral hepatitis, with accelerated progression to liver cirrhosis and hepatocellular carcinoma. About 74 million of HBV surface antigen (HBsAg) positive patients worldwide are also co-infected with HDV. Besides, patients with intravenous drug use and high-risk sexual behavior are at higher risk of HDV infection. Therapeutic schedules for HDV are limited, and relapse of HDV has ...
Source: Gut Pathogens - October 30, 2021 Category: Microbiology Source Type: research
The complete genome sequence of a bile-isolated Stenotrophomonas maltophilia ZT1
ConclusionsThis is the first study to reveal the whole genome sequence of the ZT1 strain ofS. maltophilia isolated from human bile. We identified hundreds virulence factors and 22 bile adaptation-related genes in the genome of theS. maltophilia strain ZT1. Further comparative genomic analysis and functional verification would aid in understanding the pathogenesis and bile adaptation ofS. maltophilia. (Source: Gut Pathogens)
Source: Gut Pathogens - October 28, 2021 Category: Microbiology Source Type: research
Interaction between PSMD10 and GRP78 accelerates endoplasmic reticulum stress-mediated hepatic apoptosis induced by homocysteine
ConclusionsOur findings indicate that miR-212-5p directly targets PSMD10 and subsequently activates ER stress to promote Hcy-induced apoptosis of hepatocytes. We propose that endogenous PSMD10 physically interacts with GRP78 to regulate ER stress. Our study may provide the therapeutic target for the liver injury induced by Hcy. (Source: Gut Pathogens)
Source: Gut Pathogens - October 19, 2021 Category: Microbiology Source Type: research
Improved gut microbiota features after the resolution of SARS ‑CoV‑2 infection
ConclusionSARS-CoV-2 infection is associated with changes in the gut microbiome, which tend to be reversed in long-term period. (Source: Gut Pathogens)
Source: Gut Pathogens - October 16, 2021 Category: Microbiology Source Type: research
Coinfection of Clostridium perfringens and Escherichia coli in gas-producing perianal abscess diagnosed by 16S rDNA sequencing: a case report
ConclusionsThis case represents the first report of coinfection of both clostridial and non-clostridial organisms in gas-producing perianal abscess and the first case reporting the use of 16S rDNA sequencing in the diagnosis of perianal abscess. Timely pathogen identification is critical for treating gas-producing perianal abscess and an antibiotic regimen covering both aerobic and anaerobic organisms is recommended before true pathogens are identified. (Source: Gut Pathogens)
Source: Gut Pathogens - October 13, 2021 Category: Microbiology Source Type: research
Impact of Helicobacter pylori eradication on the gastric microbiome
ConclusionsAfter Hp infection, the diversity and relative abundance of gastric microflora were significantly decreased. Yet, gastric microbiota could be partially restored to the Hp-negative status after eradication. Still, this effect was incomplete and might contribute to the long-term risks. (Source: Gut Pathogens)
Source: Gut Pathogens - October 13, 2021 Category: Microbiology Source Type: research
Comparative genomic characterization of multidrug-resistant Citrobacter spp. strains in Fennec fox imported to China
ConclusionsTo our knowledge, this is the first investigation of MDR-Citrobacter from Fennec Fox. Our phenotypic and genomic data further underscore the threat of increased ESBL prevalence in wildlife and emphasize that increased effort should be committed to monitoring the potentially rapid dissemination of ESBL-producers with one health perspective. (Source: Gut Pathogens)
Source: Gut Pathogens - October 13, 2021 Category: Microbiology Source Type: research
Compositional variation of the human fecal microbiome in relation to azo-reducing activity: a pilot study
ConclusionsThis pilot study showed that stool samples with higher azo-reducing activity were enriched in Firmicutes but with relatively fewer Bacteroidetes. More samples and studies from different geographical areas are needed to bolster this conclusion. Better characterization of different azoreductase-producing gut microbes will increase our knowledge about the fate and differential human responses to azodye-containing drugs or orally consumed chemicals, thus contributing to efforts towards implementing microbiome testing in precision medicine and toxicology. (Source: Gut Pathogens)
Source: Gut Pathogens - October 8, 2021 Category: Microbiology Source Type: research
The endemic Helicobacter pylori population in Southern Vietnam has both South East Asian and European origins
ConclusionsThere are two predominant lineages ofH. pylori circulating in Vietnam; most of the isolates belong to the hspEastAsia population. The hpEurope population is further divided into two smaller clusters. (Source: Gut Pathogens)
Source: Gut Pathogens - September 30, 2021 Category: Microbiology Source Type: research
Association of LRRK2 rs11564258 single nucleotide polymorphisms with type and extent of gastrointestinal mycobiome in ulcerative colitis: a case –control study
ConclusionsHere, we disclosed that LRRK2 mediates Dectin-1 signaling pathway activation and subsequent inflammation in the UC patients without being affected by the presence of SNPrs11564258. Our data showed an increased global fungal load in the UC patients along with elevated UC susceptibility in cases carryingrs11564258 polymorphism. However, more clinical investigations, particularly in larger populations with different ethnic groups, are required to support this conclusion. (Source: Gut Pathogens)
Source: Gut Pathogens - September 30, 2021 Category: Microbiology Source Type: research
Genomic characterization of nine Clostridioides difficile strains isolated from Korean patients with Clostridioides difficile infection
ConclusionIn this study, we identified the specific genomic characteristics of KoreanC. difficile strains, which could serve as basic information for CDI prevention and treatment in Korea. (Source: Gut Pathogens)
Source: Gut Pathogens - September 16, 2021 Category: Microbiology Source Type: research
The use of biomarkers associated with leaky gut as a diagnostic tool for early intervention in autism spectrum disorder: a systematic review
ConclusionAlthough the cause-to-effect relationship between ASD and altered gut microbiota is not yet well understood, this review shows that with the consumption of specific diets, definite probiotics may represent a noninvasive tool to reestablish healthy gut microbiota and stimulate gut health. The diagnostic and therapeutic value of intestinal proteins and bacterial-derived compounds as new possible biomarkers, as well as potential therapeutic targets, are discussed. (Source: Gut Pathogens)
Source: Gut Pathogens - September 13, 2021 Category: Microbiology Source Type: research
