A multi-omics study to investigate the progression of the Correa pathway in gastric mucosa in the context of cirrhosis

ConclusionsThe alterations in the gastric mucosal microbiome and transcriptome of LC patients were identified. The impaired energy metabolism in gastric mucosal cells and bile acids might aggravate the inflammation of gastric mucosa and even exacerbate the Correa ’s cascade process. The gastric mucosal cells might reduce bile acid toxicity by bile acid efflux and detoxification.Trial registration: ChiCTR2100051070.
Source: Gut Pathogens - Category: Microbiology Source Type: research