Cellular spartans at the pass: Emerging intricacies of cell competition in early and late tumorigenesis
This article sheds light on the emerging complexity of cell competition by highlighting recent studies that unveil its context dependency. Finally, we propose that tissue histomorphology implies a crucial role for cell competition at tumor invasion fronts particularly in metastases, warranting increased attention in future studies.PMID:38181657 | DOI:10.1016/j.ceb.2023.102315 (Source: Current Opinion in Cell Biology)
Source: Current Opinion in Cell Biology - January 5, 2024 Category: Cytology Authors: Carlos Fern ández Moro Natalie Geyer Marco Gerling Source Type: research
Creative processes during vertebrate organ morphogenesis: Biophysical self-organization at the supracellular scale
Curr Opin Cell Biol. 2024 Jan 4;86:102305. doi: 10.1016/j.ceb.2023.102305. Online ahead of print.ABSTRACTHere, we review recent developments in the literature that provide insight into self-organization at supracellular scales in vertebrate organ morphogenesis. We briefly present a historical and conceptual analysis of the term "self-organization." Based on this analysis, we suggest that self-organizing processes, at their root, possess a form of causal relationship, reciprocal causality, that is markedly distinct from linear causal chains. We survey the extent to which reciprocal causality can be used to interpret or clar...
Source: Current Opinion in Cell Biology - January 5, 2024 Category: Cytology Authors: Charlotte R Pfeifer Amy E Shyer Alan R Rodrigues Source Type: research
Mechanobiology of myeloid cells
Curr Opin Cell Biol. 2024 Jan 3;86:102311. doi: 10.1016/j.ceb.2023.102311. Online ahead of print.ABSTRACTTissue-resident myeloid cells sense and transduce mechanical signals such as stiffness, stretch and compression. In the past two years, our understanding of the mechanosensitive signalling pathways in myeloid cells has significantly expanded. Moreover, it is increasingly clear which mechanical signals induce myeloid cells towards a pro- or anti-inflammatory phenotype. This is especially relevant in the context of altered matrix mechanics in immune-related pathologies or in the response to implanted biomaterials. A detai...
Source: Current Opinion in Cell Biology - January 4, 2024 Category: Cytology Authors: Eline Janssen Koen van den Dries Maurizio Ventre Alessandra Cambi Source Type: research
Pulling the strings on solid-to-liquid phase transitions in cell collectives
Curr Opin Cell Biol. 2024 Jan 3;86:102310. doi: 10.1016/j.ceb.2023.102310. Online ahead of print.ABSTRACTCell collectives must dynamically adapt to different biological contexts. For instance, in homeostatic conditions, epithelia must establish a barrier between body compartments and resist external stresses, while during development, wound healing or cancer invasion, these tissues undergo extensive remodeling. Using analogies from inert, passive materials, changes in cellular density, shape, rearrangements and/or migration were shown to result in collective transitions between solid and fluid states. However, what biologi...
Source: Current Opinion in Cell Biology - January 4, 2024 Category: Cytology Authors: Diana Pinheiro Jennifer Mitchel Source Type: research
Mechanobiology of myeloid cells
Curr Opin Cell Biol. 2024 Jan 3;86:102311. doi: 10.1016/j.ceb.2023.102311. Online ahead of print.ABSTRACTTissue-resident myeloid cells sense and transduce mechanical signals such as stiffness, stretch and compression. In the past two years, our understanding of the mechanosensitive signalling pathways in myeloid cells has significantly expanded. Moreover, it is increasingly clear which mechanical signals induce myeloid cells towards a pro- or anti-inflammatory phenotype. This is especially relevant in the context of altered matrix mechanics in immune-related pathologies or in the response to implanted biomaterials. A detai...
Source: Current Opinion in Cell Biology - January 4, 2024 Category: Cytology Authors: Eline Janssen Koen van den Dries Maurizio Ventre Alessandra Cambi Source Type: research
Pulling the strings on solid-to-liquid phase transitions in cell collectives
Curr Opin Cell Biol. 2024 Jan 3;86:102310. doi: 10.1016/j.ceb.2023.102310. Online ahead of print.ABSTRACTCell collectives must dynamically adapt to different biological contexts. For instance, in homeostatic conditions, epithelia must establish a barrier between body compartments and resist external stresses, while during development, wound healing or cancer invasion, these tissues undergo extensive remodeling. Using analogies from inert, passive materials, changes in cellular density, shape, rearrangements and/or migration were shown to result in collective transitions between solid and fluid states. However, what biologi...
Source: Current Opinion in Cell Biology - January 4, 2024 Category: Cytology Authors: Diana Pinheiro Jennifer Mitchel Source Type: research
Lipid nanodomains and receptor signaling: From actin-based organization to membrane mechanics
Curr Opin Cell Biol. 2024 Jan 1;86:102308. doi: 10.1016/j.ceb.2023.102308. Online ahead of print.ABSTRACTThe plasma membrane serves as the primary barrier between the cell's interior and its external surroundings, which places it at the forefront of intercellular communication, receptor signal transduction and the integration of mechanical forces from outside. Most of these signals are largely dependent on the plasma membrane heterogeneity which relies on lipid-lipid and lipid-protein interactions and the lateral nano-distribution of lipids organized by the dynamic network of cortical actin. In this review, we undertake an...
Source: Current Opinion in Cell Biology - January 3, 2024 Category: Cytology Authors: Changting Li Yazmina Quintana Perez Christophe Lamaze Cedric M Blouin Source Type: research
Vimentin cage - A double-edged sword in host anti-infection defense
Curr Opin Cell Biol. 2024 Jan 2;86:102317. doi: 10.1016/j.ceb.2023.102317. Online ahead of print.ABSTRACTVimentin, a type III intermediate filament, reorganizes into what is termed the 'vimentin cage' in response to various pathogenic infections. This cage-like structure provides an envelope to key components of the pathogen's life cycle. In viral infections, the vimentin cage primarily serves as a scaffold and organizer for the replication factory, promoting viral replication. However, it also occasionally contributes to antiviral functions. For bacterial infections, the cage mainly supports bacterial proliferation in mos...
Source: Current Opinion in Cell Biology - January 3, 2024 Category: Cytology Authors: Shuangshuang Zhao Chenglin Miao Xuedi Gao Zhifang Li John E Eriksson Yaming Jiu Source Type: research
Lipid nanodomains and receptor signaling: From actin-based organization to membrane mechanics
Curr Opin Cell Biol. 2024 Jan 1;86:102308. doi: 10.1016/j.ceb.2023.102308. Online ahead of print.ABSTRACTThe plasma membrane serves as the primary barrier between the cell's interior and its external surroundings, which places it at the forefront of intercellular communication, receptor signal transduction and the integration of mechanical forces from outside. Most of these signals are largely dependent on the plasma membrane heterogeneity which relies on lipid-lipid and lipid-protein interactions and the lateral nano-distribution of lipids organized by the dynamic network of cortical actin. In this review, we undertake an...
Source: Current Opinion in Cell Biology - January 3, 2024 Category: Cytology Authors: Changting Li Yazmina Quintana Perez Christophe Lamaze Cedric M Blouin Source Type: research
Vimentin cage - A double-edged sword in host anti-infection defense
Curr Opin Cell Biol. 2024 Jan 2;86:102317. doi: 10.1016/j.ceb.2023.102317. Online ahead of print.ABSTRACTVimentin, a type III intermediate filament, reorganizes into what is termed the 'vimentin cage' in response to various pathogenic infections. This cage-like structure provides an envelope to key components of the pathogen's life cycle. In viral infections, the vimentin cage primarily serves as a scaffold and organizer for the replication factory, promoting viral replication. However, it also occasionally contributes to antiviral functions. For bacterial infections, the cage mainly supports bacterial proliferation in mos...
Source: Current Opinion in Cell Biology - January 3, 2024 Category: Cytology Authors: Shuangshuang Zhao Chenglin Miao Xuedi Gao Zhifang Li John E Eriksson Yaming Jiu Source Type: research
Astrocyte signaling and interactions in Multiple Sclerosis
Curr Opin Cell Biol. 2023 Dec 24;86:102307. doi: 10.1016/j.ceb.2023.102307. Online ahead of print.ABSTRACTMultiple Sclerosis (MS) is a common cause of impairment in working-aged adults. MS is characterized by neuroinflammation and infiltration of peripheral immune cells to the brain, which cause myelin loss and death of oligodendrocytes and neurons. Many studies on MS have focused on the peripheral immune sources of demyelination and repair. However, recent studies revealed that a glial cell type, the astrocytes, undergo robust morphological and transcriptomic changes that contribute significantly to demyelination and myel...
Source: Current Opinion in Cell Biology - December 25, 2023 Category: Cytology Authors: Crystal Col ón Ortiz Cagla Eroglu Source Type: research
Astrocyte signaling and interactions in Multiple Sclerosis
Curr Opin Cell Biol. 2023 Dec 24;86:102307. doi: 10.1016/j.ceb.2023.102307. Online ahead of print.ABSTRACTMultiple Sclerosis (MS) is a common cause of impairment in working-aged adults. MS is characterized by neuroinflammation and infiltration of peripheral immune cells to the brain, which cause myelin loss and death of oligodendrocytes and neurons. Many studies on MS have focused on the peripheral immune sources of demyelination and repair. However, recent studies revealed that a glial cell type, the astrocytes, undergo robust morphological and transcriptomic changes that contribute significantly to demyelination and myel...
Source: Current Opinion in Cell Biology - December 25, 2023 Category: Cytology Authors: Crystal Col ón Ortiz Cagla Eroglu Source Type: research
Astrocyte signaling and interactions in Multiple Sclerosis
Curr Opin Cell Biol. 2023 Dec 24;86:102307. doi: 10.1016/j.ceb.2023.102307. Online ahead of print.ABSTRACTMultiple Sclerosis (MS) is a common cause of impairment in working-aged adults. MS is characterized by neuroinflammation and infiltration of peripheral immune cells to the brain, which cause myelin loss and death of oligodendrocytes and neurons. Many studies on MS have focused on the peripheral immune sources of demyelination and repair. However, recent studies revealed that a glial cell type, the astrocytes, undergo robust morphological and transcriptomic changes that contribute significantly to demyelination and myel...
Source: Current Opinion in Cell Biology - December 25, 2023 Category: Cytology Authors: Crystal Col ón Ortiz Cagla Eroglu Source Type: research
Astrocyte signaling and interactions in Multiple Sclerosis
Curr Opin Cell Biol. 2023 Dec 24;86:102307. doi: 10.1016/j.ceb.2023.102307. Online ahead of print.ABSTRACTMultiple Sclerosis (MS) is a common cause of impairment in working-aged adults. MS is characterized by neuroinflammation and infiltration of peripheral immune cells to the brain, which cause myelin loss and death of oligodendrocytes and neurons. Many studies on MS have focused on the peripheral immune sources of demyelination and repair. However, recent studies revealed that a glial cell type, the astrocytes, undergo robust morphological and transcriptomic changes that contribute significantly to demyelination and myel...
Source: Current Opinion in Cell Biology - December 25, 2023 Category: Cytology Authors: Crystal Col ón Ortiz Cagla Eroglu Source Type: research
Astrocyte signaling and interactions in Multiple Sclerosis
Curr Opin Cell Biol. 2023 Dec 24;86:102307. doi: 10.1016/j.ceb.2023.102307. Online ahead of print.ABSTRACTMultiple Sclerosis (MS) is a common cause of impairment in working-aged adults. MS is characterized by neuroinflammation and infiltration of peripheral immune cells to the brain, which cause myelin loss and death of oligodendrocytes and neurons. Many studies on MS have focused on the peripheral immune sources of demyelination and repair. However, recent studies revealed that a glial cell type, the astrocytes, undergo robust morphological and transcriptomic changes that contribute significantly to demyelination and myel...
Source: Current Opinion in Cell Biology - December 25, 2023 Category: Cytology Authors: Crystal Col ón Ortiz Cagla Eroglu Source Type: research
