Astrocyte signaling and interactions in Multiple Sclerosis

Curr Opin Cell Biol. 2023 Dec 24;86:102307. doi: 10.1016/j.ceb.2023.102307. Online ahead of print.ABSTRACTMultiple Sclerosis (MS) is a common cause of impairment in working-aged adults. MS is characterized by neuroinflammation and infiltration of peripheral immune cells to the brain, which cause myelin loss and death of oligodendrocytes and neurons. Many studies on MS have focused on the peripheral immune sources of demyelination and repair. However, recent studies revealed that a glial cell type, the astrocytes, undergo robust morphological and transcriptomic changes that contribute significantly to demyelination and myelin repair. Here, we discuss recent findings elucidating signaling modalities that astrocytes acquire or lose in MS and how these changes alter the interactions of astrocytes with other nervous system cell types.PMID:38145604 | DOI:10.1016/j.ceb.2023.102307

Source: Current Opinion in Cell Biology - December 25, 2023 Category: Cytology Authors: Crystal Col ón Ortiz Cagla Eroglu Source Type: research