Physical forces modulate interphase nuclear size
Curr Opin Cell Biol. 2023 Oct 4;85:102253. doi: 10.1016/j.ceb.2023.102253. Online ahead of print.ABSTRACTThe eukaryotic nucleus exhibits remarkable plasticity in size, adjusting dynamically to changes in cellular conditions such as during development and differentiation, and across species. Traditionally, the supply of structural constituents to the nuclear envelope has been proposed as the principal determinant of nuclear size. However, recent experimental and theoretical analyses have provided an alternative perspective, which emphasizes the crucial role of physical forces such as osmotic pressure and chromatin repulsion...
Source: Current Opinion in Cell Biology - October 6, 2023 Category: Cytology Authors: Yuki Hara Source Type: research
Phase separation in chemical and mechanical signal transduction
Curr Opin Cell Biol. 2023 Oct 1;85:102243. doi: 10.1016/j.ceb.2023.102243. Online ahead of print.ABSTRACTSignal transduction enables cells to sense and respond to chemical and mechanical information in the extracellular environment. Recently, phase separation has emerged as a physical mechanism that can influence the spatial organization of signaling molecules and regulate downstream signaling. Although many molecular components of signaling pathways, including receptors, kinases, and transcription factors, have been observed to undergo phase separation, understanding the functional consequences of their phase separation i...
Source: Current Opinion in Cell Biology - October 3, 2023 Category: Cytology Authors: Xiaohang Cheng Lindsay B Case Source Type: research
Phase separation in chemical and mechanical signal transduction
Curr Opin Cell Biol. 2023 Oct 1;85:102243. doi: 10.1016/j.ceb.2023.102243. Online ahead of print.ABSTRACTSignal transduction enables cells to sense and respond to chemical and mechanical information in the extracellular environment. Recently, phase separation has emerged as a physical mechanism that can influence the spatial organization of signaling molecules and regulate downstream signaling. Although many molecular components of signaling pathways, including receptors, kinases, and transcription factors, have been observed to undergo phase separation, understanding the functional consequences of their phase separation i...
Source: Current Opinion in Cell Biology - October 3, 2023 Category: Cytology Authors: Xiaohang Cheng Lindsay B Case Source Type: research
Phase separation in chemical and mechanical signal transduction
Curr Opin Cell Biol. 2023 Oct 1;85:102243. doi: 10.1016/j.ceb.2023.102243. Online ahead of print.ABSTRACTSignal transduction enables cells to sense and respond to chemical and mechanical information in the extracellular environment. Recently, phase separation has emerged as a physical mechanism that can influence the spatial organization of signaling molecules and regulate downstream signaling. Although many molecular components of signaling pathways, including receptors, kinases, and transcription factors, have been observed to undergo phase separation, understanding the functional consequences of their phase separation i...
Source: Current Opinion in Cell Biology - October 3, 2023 Category: Cytology Authors: Xiaohang Cheng Lindsay B Case Source Type: research
Mechanical regulation of the Notch signaling pathway
Curr Opin Cell Biol. 2023 Sep 30;85:102244. doi: 10.1016/j.ceb.2023.102244. Online ahead of print.ABSTRACTThe mechanical regulation of Notch signaling is an emerging area of interest in cell biology. Notch is essential in many physiological processes in which mechanical stress plays an important role. This review provides an overview of the mechanoregulation of Notch signaling in multiple steps of the pathway. First, we discuss the current knowledge on the direct mechanoregulation of Notch receptor maturation and localization to the membrane and the effect of mechanical stress on the Notch components. Next, we explore how ...
Source: Current Opinion in Cell Biology - October 2, 2023 Category: Cytology Authors: Freddy Suarez Rodriguez Sami Sanlidag Cecilia Sahlgren Source Type: research
Tug-of-war via ERK signaling pathway for tissue organization - ERK activation to force generation
Curr Opin Cell Biol. 2023 Sep 30;85:102249. doi: 10.1016/j.ceb.2023.102249. Online ahead of print.ABSTRACTExtracellular signal-regulated kinase (ERK) plays a crucial role in regulating collective cell behaviors observed in diverse biological phenomena. Emerging studies have shed light on the involvement of the ERK signaling pathway in the reception and generation of mechanical forces, thereby governing local mechanical interactions within multicellular tissues. Although limited in number, studies have provided insights into how ERK-mediated mechanical interactions contribute to multicellular organization. Here we explore t...
Source: Current Opinion in Cell Biology - October 2, 2023 Category: Cytology Authors: Ankita Nitin Nayak Tsuyoshi Hirashima Source Type: research
Vimentin takes a hike - Emerging roles of extracellular vimentin in cancer and wound healing
Curr Opin Cell Biol. 2023 Sep 30;85:102246. doi: 10.1016/j.ceb.2023.102246. Online ahead of print.ABSTRACTVimentin is a cytoskeletal protein important for many cellular processes, including proliferation, migration, invasion, stress resistance, signaling, and many more. The vimentin-deficient mouse has revealed many of these functions as it has numerous severe phenotypes, many of which are found only following a suitable challenge or stress. While these functions are usually related to vimentin as a major intracellular protein, vimentin is also emerging as an extracellular protein, exposed at the cell surface in an oligome...
Source: Current Opinion in Cell Biology - October 2, 2023 Category: Cytology Authors: Sepideh Parvanian Leila S Coelho-Rato Alison E Patteson John E Eriksson Source Type: research
A keratin code defines the textile nature of epithelial tissue architecture
Curr Opin Cell Biol. 2023 Sep 12;85:102236. doi: 10.1016/j.ceb.2023.102236. Online ahead of print.ABSTRACTWe suggest that the human body can be viewed as of textile nature whose fabric consists of interconnected fiber systems. These fiber systems form highly dynamic scaffolds, which respond to environmental changes at different temporal and spatial scales. This is especially relevant at sites where epithelia border on connective tissue regions that are exposed to dynamic microenvironments. We propose that the enormous heterogeneity and adaptability of epithelia are based on a "keratin code", which results from the cell-spe...
Source: Current Opinion in Cell Biology - September 14, 2023 Category: Cytology Authors: Jacopo Di Russo Thomas M Magin Rudolf E Leube Source Type: research
A keratin code defines the textile nature of epithelial tissue architecture
Curr Opin Cell Biol. 2023 Sep 12;85:102236. doi: 10.1016/j.ceb.2023.102236. Online ahead of print.ABSTRACTWe suggest that the human body can be viewed as of textile nature whose fabric consists of interconnected fiber systems. These fiber systems form highly dynamic scaffolds, which respond to environmental changes at different temporal and spatial scales. This is especially relevant at sites where epithelia border on connective tissue regions that are exposed to dynamic microenvironments. We propose that the enormous heterogeneity and adaptability of epithelia are based on a "keratin code", which results from the cell-spe...
Source: Current Opinion in Cell Biology - September 14, 2023 Category: Cytology Authors: Jacopo Di Russo Thomas M Magin Rudolf E Leube Source Type: research
A keratin code defines the textile nature of epithelial tissue architecture
Curr Opin Cell Biol. 2023 Sep 12;85:102236. doi: 10.1016/j.ceb.2023.102236. Online ahead of print.ABSTRACTWe suggest that the human body can be viewed as of textile nature whose fabric consists of interconnected fiber systems. These fiber systems form highly dynamic scaffolds, which respond to environmental changes at different temporal and spatial scales. This is especially relevant at sites where epithelia border on connective tissue regions that are exposed to dynamic microenvironments. We propose that the enormous heterogeneity and adaptability of epithelia are based on a "keratin code", which results from the cell-spe...
Source: Current Opinion in Cell Biology - September 14, 2023 Category: Cytology Authors: Jacopo Di Russo Thomas M Magin Rudolf E Leube Source Type: research
A keratin code defines the textile nature of epithelial tissue architecture
Curr Opin Cell Biol. 2023 Sep 12;85:102236. doi: 10.1016/j.ceb.2023.102236. Online ahead of print.ABSTRACTWe suggest that the human body can be viewed as of textile nature whose fabric consists of interconnected fiber systems. These fiber systems form highly dynamic scaffolds, which respond to environmental changes at different temporal and spatial scales. This is especially relevant at sites where epithelia border on connective tissue regions that are exposed to dynamic microenvironments. We propose that the enormous heterogeneity and adaptability of epithelia are based on a "keratin code", which results from the cell-spe...
Source: Current Opinion in Cell Biology - September 14, 2023 Category: Cytology Authors: Jacopo Di Russo Thomas M Magin Rudolf E Leube Source Type: research
A keratin code defines the textile nature of epithelial tissue architecture
Curr Opin Cell Biol. 2023 Sep 12;85:102236. doi: 10.1016/j.ceb.2023.102236. Online ahead of print.ABSTRACTWe suggest that the human body can be viewed as of textile nature whose fabric consists of interconnected fiber systems. These fiber systems form highly dynamic scaffolds, which respond to environmental changes at different temporal and spatial scales. This is especially relevant at sites where epithelia border on connective tissue regions that are exposed to dynamic microenvironments. We propose that the enormous heterogeneity and adaptability of epithelia are based on a "keratin code", which results from the cell-spe...
Source: Current Opinion in Cell Biology - September 14, 2023 Category: Cytology Authors: Jacopo Di Russo Thomas M Magin Rudolf E Leube Source Type: research
A keratin code defines the textile nature of epithelial tissue architecture
Curr Opin Cell Biol. 2023 Sep 12;85:102236. doi: 10.1016/j.ceb.2023.102236. Online ahead of print.ABSTRACTWe suggest that the human body can be viewed as of textile nature whose fabric consists of interconnected fiber systems. These fiber systems form highly dynamic scaffolds, which respond to environmental changes at different temporal and spatial scales. This is especially relevant at sites where epithelia border on connective tissue regions that are exposed to dynamic microenvironments. We propose that the enormous heterogeneity and adaptability of epithelia are based on a "keratin code", which results from the cell-spe...
Source: Current Opinion in Cell Biology - September 14, 2023 Category: Cytology Authors: Jacopo Di Russo Thomas M Magin Rudolf E Leube Source Type: research
A keratin code defines the textile nature of epithelial tissue architecture
Curr Opin Cell Biol. 2023 Sep 12;85:102236. doi: 10.1016/j.ceb.2023.102236. Online ahead of print.ABSTRACTWe suggest that the human body can be viewed as of textile nature whose fabric consists of interconnected fiber systems. These fiber systems form highly dynamic scaffolds, which respond to environmental changes at different temporal and spatial scales. This is especially relevant at sites where epithelia border on connective tissue regions that are exposed to dynamic microenvironments. We propose that the enormous heterogeneity and adaptability of epithelia are based on a "keratin code", which results from the cell-spe...
Source: Current Opinion in Cell Biology - September 14, 2023 Category: Cytology Authors: Jacopo Di Russo Thomas M Magin Rudolf E Leube Source Type: research
A keratin code defines the textile nature of epithelial tissue architecture
Curr Opin Cell Biol. 2023 Sep 12;85:102236. doi: 10.1016/j.ceb.2023.102236. Online ahead of print.ABSTRACTWe suggest that the human body can be viewed as of textile nature whose fabric consists of interconnected fiber systems. These fiber systems form highly dynamic scaffolds, which respond to environmental changes at different temporal and spatial scales. This is especially relevant at sites where epithelia border on connective tissue regions that are exposed to dynamic microenvironments. We propose that the enormous heterogeneity and adaptability of epithelia are based on a "keratin code", which results from the cell-spe...
Source: Current Opinion in Cell Biology - September 14, 2023 Category: Cytology Authors: Jacopo Di Russo Thomas M Magin Rudolf E Leube Source Type: research
