AAA ATPase protein-protein interactions as therapeutic targets in cancer
Curr Opin Cell Biol. 2023 Dec 5;86:102291. doi: 10.1016/j.ceb.2023.102291. Online ahead of print.ABSTRACTAAA ATPases are a conserved group of enzymes that couple ATP hydrolysis to diverse activities critical for cellular homeostasis by targeted protein-protein interactions. Some of these interactions are potential therapeutic targets because of their role in cancers which rely on increased AAA ATPase activities for maintenance of genomic stability. Two well-characterized members of this family are p97/VCP and RUVBL ATPases where there is a growing understanding of their structure and function, as well as an emerging landsc...
Source: Current Opinion in Cell Biology - December 6, 2023 Category: Cytology Authors: Dhiraj Mannar Sana Ahmed Sriram Subramaniam Source Type: research
The ubiquitous nanocluster: A molecular scale organizing principle that governs cellular information flow
Curr Opin Cell Biol. 2023 Dec 5;86:102285. doi: 10.1016/j.ceb.2023.102285. Online ahead of print.ABSTRACTThe language of biology at the scale of the cell is constituted of alphabets represented by biomolecules. These are stitched together in a variety of ways to create meaning. We argue that the phrases of this language are nanoscale molecular assemblies or nano-hubs for the purpose of information flow. At the cell surface information is sensed and processed via membrane receptors, often configured as multimers. These nano-assemblies serve as receiver nano-hubs, which are flexibly configured with additional nano-hubs that ...
Source: Current Opinion in Cell Biology - December 6, 2023 Category: Cytology Authors: Maria F Garcia-Parajo Satyajit Mayor Source Type: research
Cell cycle control by cell-matrix interactions
Curr Opin Cell Biol. 2023 Dec 5;86:102288. doi: 10.1016/j.ceb.2023.102288. Online ahead of print.ABSTRACTCell adhesion to the extracellular matrix (ECM) is required for normal cell cycle progression and accurate cell division. However, how cell adhesion to the wide range of ECM proteins found in human tissues influences the cell cycle is not fully understood. The composition and physical properties of the ECM can have profound effects on cell proliferation but can also promote cell cycle exit and quiescence. Furthermore, during tumor development and progression, changes in the ECM can drive both cancer cell proliferation a...
Source: Current Opinion in Cell Biology - December 6, 2023 Category: Cytology Authors: Michael J Jones Matthew C Jones Source Type: research
AAA ATPase protein-protein interactions as therapeutic targets in cancer
Curr Opin Cell Biol. 2023 Dec 5;86:102291. doi: 10.1016/j.ceb.2023.102291. Online ahead of print.ABSTRACTAAA ATPases are a conserved group of enzymes that couple ATP hydrolysis to diverse activities critical for cellular homeostasis by targeted protein-protein interactions. Some of these interactions are potential therapeutic targets because of their role in cancers which rely on increased AAA ATPase activities for maintenance of genomic stability. Two well-characterized members of this family are p97/VCP and RUVBL ATPases where there is a growing understanding of their structure and function, as well as an emerging landsc...
Source: Current Opinion in Cell Biology - December 6, 2023 Category: Cytology Authors: Dhiraj Mannar Sana Ahmed Sriram Subramaniam Source Type: research
The ubiquitous nanocluster: A molecular scale organizing principle that governs cellular information flow
Curr Opin Cell Biol. 2023 Dec 5;86:102285. doi: 10.1016/j.ceb.2023.102285. Online ahead of print.ABSTRACTThe language of biology at the scale of the cell is constituted of alphabets represented by biomolecules. These are stitched together in a variety of ways to create meaning. We argue that the phrases of this language are nanoscale molecular assemblies or nano-hubs for the purpose of information flow. At the cell surface information is sensed and processed via membrane receptors, often configured as multimers. These nano-assemblies serve as receiver nano-hubs, which are flexibly configured with additional nano-hubs that ...
Source: Current Opinion in Cell Biology - December 6, 2023 Category: Cytology Authors: Maria F Garcia-Parajo Satyajit Mayor Source Type: research
How nuclear envelope dynamics can direct laminopathy phenotypes
Curr Opin Cell Biol. 2023 Dec 3;86:102290. doi: 10.1016/j.ceb.2023.102290. Online ahead of print.ABSTRACTThe nuclear envelope separates the genome from the cytoplasmic environment. However, the nuclear envelope is also physically associated with the genome and exerts influence on gene expression and genome modification. The nucleus is dynamic, changing shape and responding to cell movement, disassembling and assembling during cell division, and undergoing rupture and repair. These dynamics can be impacted by genetic disease, leading to a family of diseases called laminopathies. Their disparate phenotypes suggest that multi...
Source: Current Opinion in Cell Biology - December 4, 2023 Category: Cytology Authors: David van Heerden Stefanie Klima Iman van den Bout Source Type: research
Cytoskeletal dynamics in parasites
Curr Opin Cell Biol. 2023 Dec 3;86:102277. doi: 10.1016/j.ceb.2023.102277. Online ahead of print.ABSTRACTCytoskeletal dynamics are essential for cellular homeostasis and development for both metazoans and protozoans. The function of cytoskeletal elements in protozoans can diverge from that of metazoan cells, with microtubules being more stable and actin filaments being more dynamic. This is particularly striking in protozoan parasites that evolved to enter metazoan cells. Here, we review recent progress towards understanding cytoskeletal dynamics in protozoan parasites, with a focus on divergent properties compared to clas...
Source: Current Opinion in Cell Biology - December 4, 2023 Category: Cytology Authors: Simone Reber Mirko Singer Friedrich Frischknecht Source Type: research
How nuclear envelope dynamics can direct laminopathy phenotypes
Curr Opin Cell Biol. 2023 Dec 3;86:102290. doi: 10.1016/j.ceb.2023.102290. Online ahead of print.ABSTRACTThe nuclear envelope separates the genome from the cytoplasmic environment. However, the nuclear envelope is also physically associated with the genome and exerts influence on gene expression and genome modification. The nucleus is dynamic, changing shape and responding to cell movement, disassembling and assembling during cell division, and undergoing rupture and repair. These dynamics can be impacted by genetic disease, leading to a family of diseases called laminopathies. Their disparate phenotypes suggest that multi...
Source: Current Opinion in Cell Biology - December 4, 2023 Category: Cytology Authors: David van Heerden Stefanie Klima Iman van den Bout Source Type: research
Cytoskeletal dynamics in parasites
Curr Opin Cell Biol. 2023 Dec 3;86:102277. doi: 10.1016/j.ceb.2023.102277. Online ahead of print.ABSTRACTCytoskeletal dynamics are essential for cellular homeostasis and development for both metazoans and protozoans. The function of cytoskeletal elements in protozoans can diverge from that of metazoan cells, with microtubules being more stable and actin filaments being more dynamic. This is particularly striking in protozoan parasites that evolved to enter metazoan cells. Here, we review recent progress towards understanding cytoskeletal dynamics in protozoan parasites, with a focus on divergent properties compared to clas...
Source: Current Opinion in Cell Biology - December 4, 2023 Category: Cytology Authors: Simone Reber Mirko Singer Friedrich Frischknecht Source Type: research
Microtubule control of migration: Coordination in confinement
Curr Opin Cell Biol. 2023 Dec 1;86:102289. doi: 10.1016/j.ceb.2023.102289. Online ahead of print.ABSTRACTThe microtubule cytoskeleton has a well-established, instrumental role in coordinating cell migration. Decades of research has focused on understanding how microtubules couple intracellular trafficking with cortical targeting and spatial organization of signaling to facilitate locomotion. Movement in physically challenging environments requires coordination of forces generated by the actin cytoskeleton to drive cell shape changes, with microtubules acting to spatially regulate contractility. Recent work has demonstrated...
Source: Current Opinion in Cell Biology - December 2, 2023 Category: Cytology Authors: Christanny J Schmidt Samantha J Stehbens Source Type: research
Microtubule control of migration: Coordination in confinement
Curr Opin Cell Biol. 2023 Dec 1;86:102289. doi: 10.1016/j.ceb.2023.102289. Online ahead of print.ABSTRACTThe microtubule cytoskeleton has a well-established, instrumental role in coordinating cell migration. Decades of research has focused on understanding how microtubules couple intracellular trafficking with cortical targeting and spatial organization of signaling to facilitate locomotion. Movement in physically challenging environments requires coordination of forces generated by the actin cytoskeleton to drive cell shape changes, with microtubules acting to spatially regulate contractility. Recent work has demonstrated...
Source: Current Opinion in Cell Biology - December 2, 2023 Category: Cytology Authors: Christanny J Schmidt Samantha J Stehbens Source Type: research
Mechanisms and functions of multiciliary coordination
Curr Opin Cell Biol. 2023 Nov 29;86:102286. doi: 10.1016/j.ceb.2023.102286. Online ahead of print.ABSTRACTCiliated organisms are present in virtually every branch of the eukaryotic tree of life. In diverse systems, cilia operate in a coordinated manner to drive fluid flows, or even propel entire organisms. How do groups of motile cilia coordinate their activity within a cell or across a tissue to fulfil essential functions of life? In this review, we highlight the latest developments in our understanding of the mechanisms and functions of multiciliary coordination in diverse systems. We explore new and emerging trends in b...
Source: Current Opinion in Cell Biology - November 30, 2023 Category: Cytology Authors: Kirsty Y Wan Rebecca N Poon Source Type: research
Mechanisms and functions of multiciliary coordination
Curr Opin Cell Biol. 2023 Nov 29;86:102286. doi: 10.1016/j.ceb.2023.102286. Online ahead of print.ABSTRACTCiliated organisms are present in virtually every branch of the eukaryotic tree of life. In diverse systems, cilia operate in a coordinated manner to drive fluid flows, or even propel entire organisms. How do groups of motile cilia coordinate their activity within a cell or across a tissue to fulfil essential functions of life? In this review, we highlight the latest developments in our understanding of the mechanisms and functions of multiciliary coordination in diverse systems. We explore new and emerging trends in b...
Source: Current Opinion in Cell Biology - November 30, 2023 Category: Cytology Authors: Kirsty Y Wan Rebecca N Poon Source Type: research
Mechanisms and functions of multiciliary coordination
Curr Opin Cell Biol. 2023 Nov 29;86:102286. doi: 10.1016/j.ceb.2023.102286. Online ahead of print.ABSTRACTCiliated organisms are present in virtually every branch of the eukaryotic tree of life. In diverse systems, cilia operate in a coordinated manner to drive fluid flows, or even propel entire organisms. How do groups of motile cilia coordinate their activity within a cell or across a tissue to fulfil essential functions of life? In this review, we highlight the latest developments in our understanding of the mechanisms and functions of multiciliary coordination in diverse systems. We explore new and emerging trends in b...
Source: Current Opinion in Cell Biology - November 30, 2023 Category: Cytology Authors: Kirsty Y Wan Rebecca N Poon Source Type: research
Disturbed endothelial cell signaling in tumor progression and therapy resistance
Curr Opin Cell Biol. 2023 Nov 28;86:102287. doi: 10.1016/j.ceb.2023.102287. Online ahead of print.ABSTRACTGrowth of new blood vessels is considered requisite to cancer progression. Recent findings revealed that in addition to inducing angiogenesis, tumor-derived factors alter endothelial cell gene transcription within the tumor mass but also systemically throughout the body. This subsequently contributes to immunosuppression, altered metabolism, therapy resistance and metastasis. Clinical studies demonstrated that targeting the endothelium can increase the success rate of immunotherapy. Single-cell technologies revealed re...
Source: Current Opinion in Cell Biology - November 29, 2023 Category: Cytology Authors: Andreas Fischer Elisenda Alsina-Sanchis Source Type: research
