Notch-mediated cellular interactions between vascular cells
Curr Opin Cell Biol. 2023 Oct 11;85:102254. doi: 10.1016/j.ceb.2023.102254. Online ahead of print.ABSTRACTVessel formation and differentiation to a proper hierarchical vasculature requires a coordinated effort from endothelial and mural cells. Over the last decade Notch was identified as a key player in this process by promoting vascular arterialization and modulating endothelial tip-stalk phenotypes. Recent work has identified that Notch fine-tunes the diverse endothelial phenotypes through regulation of canonical cell-cycle and metabolism regulators, such as ERK and Myc. During arterialization, Notch signaling inhibits t...
Source: Current Opinion in Cell Biology - October 13, 2023 Category: Cytology Authors: Henar Cuervo Severin M ühleder Irene Garc ía-Gónzalez Rui Benedito Source Type: research
Protein condensates as flexible platforms for membrane traffic
Curr Opin Cell Biol. 2023 Oct 11;85:102258. doi: 10.1016/j.ceb.2023.102258. Online ahead of print.ABSTRACTWith an essential role in nearly every physiological process and disease state, trafficking vesicles are fundamental to cell biology. Canonical understanding of membrane traffic has been driven by key achievements in structural biology. Nonetheless, discoveries over the past few years progressively point to the critical role of intrinsically disordered domains and proteins, which lack a well-defined secondary structure. From the initiation of endocytosis and the sequestration of synaptic vesicles to the stabilization o...
Source: Current Opinion in Cell Biology - October 13, 2023 Category: Cytology Authors: Florian Wilfling Marko Kaksonen Jeanne Stachowiak Source Type: research
Notch-mediated cellular interactions between vascular cells
Curr Opin Cell Biol. 2023 Oct 11;85:102254. doi: 10.1016/j.ceb.2023.102254. Online ahead of print.ABSTRACTVessel formation and differentiation to a proper hierarchical vasculature requires a coordinated effort from endothelial and mural cells. Over the last decade Notch was identified as a key player in this process by promoting vascular arterialization and modulating endothelial tip-stalk phenotypes. Recent work has identified that Notch fine-tunes the diverse endothelial phenotypes through regulation of canonical cell-cycle and metabolism regulators, such as ERK and Myc. During arterialization, Notch signaling inhibits t...
Source: Current Opinion in Cell Biology - October 13, 2023 Category: Cytology Authors: Henar Cuervo Severin M ühleder Irene Garc ía-Gónzalez Rui Benedito Source Type: research
Protein condensates as flexible platforms for membrane traffic
Curr Opin Cell Biol. 2023 Oct 11;85:102258. doi: 10.1016/j.ceb.2023.102258. Online ahead of print.ABSTRACTWith an essential role in nearly every physiological process and disease state, trafficking vesicles are fundamental to cell biology. Canonical understanding of membrane traffic has been driven by key achievements in structural biology. Nonetheless, discoveries over the past few years progressively point to the critical role of intrinsically disordered domains and proteins, which lack a well-defined secondary structure. From the initiation of endocytosis and the sequestration of synaptic vesicles to the stabilization o...
Source: Current Opinion in Cell Biology - October 13, 2023 Category: Cytology Authors: Florian Wilfling Marko Kaksonen Jeanne Stachowiak Source Type: research
Notch-mediated cellular interactions between vascular cells
Curr Opin Cell Biol. 2023 Oct 11;85:102254. doi: 10.1016/j.ceb.2023.102254. Online ahead of print.ABSTRACTVessel formation and differentiation to a proper hierarchical vasculature requires a coordinated effort from endothelial and mural cells. Over the last decade Notch was identified as a key player in this process by promoting vascular arterialization and modulating endothelial tip-stalk phenotypes. Recent work has identified that Notch fine-tunes the diverse endothelial phenotypes through regulation of canonical cell-cycle and metabolism regulators, such as ERK and Myc. During arterialization, Notch signaling inhibits t...
Source: Current Opinion in Cell Biology - October 13, 2023 Category: Cytology Authors: Henar Cuervo Severin M ühleder Irene Garc ía-Gónzalez Rui Benedito Source Type: research
The impact of altered lamin B1 levels on nuclear lamina structure and function in aging and human diseases
Curr Opin Cell Biol. 2023 Oct 6;85:102257. doi: 10.1016/j.ceb.2023.102257. Online ahead of print.ABSTRACTThe role of lamin B1 in human health and aging has attracted increasing attention as mounting evidence reveals its significance in diverse cellular processes. Both upregulation and downregulation of lamin B1 have been implicated in age-associated organ dysfunctions and various human diseases, including central nervous system disorders. Additionally, lamin B1 levels undergo alterations in cancer cells, and a tumor-specific association exists between lamin B1 abundance and cancer aggressiveness. Investigating the connecti...
Source: Current Opinion in Cell Biology - October 8, 2023 Category: Cytology Authors: Youngjo Kim Source Type: research
Interplay of dynamic genome organization and biomolecular condensates
Curr Opin Cell Biol. 2023 Oct 6;85:102252. doi: 10.1016/j.ceb.2023.102252. Online ahead of print.ABSTRACTAfter 60 years of chromatin investigation, our understanding of chromatin organization has evolved from static chromatin fibers to dynamic nuclear compartmentalization. Chromatin is embedded in a heterogeneous nucleoplasm in which molecules are grouped into distinct compartments, partitioning nuclear space through phase separation. Human genome organization affects transcription which controls euchromatin formation by excluding inactive chromatin. Chromatin condensates have been described as either liquid-like or solid-...
Source: Current Opinion in Cell Biology - October 8, 2023 Category: Cytology Authors: Yu-Chieh Chung Li-Chun Tu Source Type: research
Functional domains of nuclear long noncoding RNAs: Insights into gene regulation and intracellular architecture
Curr Opin Cell Biol. 2023 Oct 6;85:102250. doi: 10.1016/j.ceb.2023.102250. Online ahead of print.ABSTRACTRecent functional research on long noncoding RNAs (lncRNAs) has revealed their significant regulatory roles in gene expression and intracellular architecture. Well-characterized examples of such lncRNAs include Xist and NEAT1_2, which play critical roles in heterochromatin formation of inactive X-chromosomes and paraspeckle assembly, in mammalian cells. Both lncRNAs possess modular domain structures with multiple functionally distinct domains that serve as platforms for specific RNA-binding proteins (RBPs), which dictat...
Source: Current Opinion in Cell Biology - October 8, 2023 Category: Cytology Authors: Chikashi Obuse Tetsuro Hirose Source Type: research
Regulation of immune cell development, differentiation and function by stromal Notch ligands
Curr Opin Cell Biol. 2023 Oct 6;85:102256. doi: 10.1016/j.ceb.2023.102256. Online ahead of print.ABSTRACTIn multicellular organisms, cell-to-cell communication is critical for the regulation of tissue organization. Notch signaling relies on direct interactions between Notch receptors on signal-receiving cells and Notch ligands on adjacent cells. Notch evolved to mediate local cellular interactions that are responsive to spatial cues via dosage-sensitive short-lived signals. Immune cells utilize these unique properties of Notch signaling to direct their development, differentiation, and function. In this review, we explore ...
Source: Current Opinion in Cell Biology - October 8, 2023 Category: Cytology Authors: Michael Schneider Anneka Allman Ivan Maillard Source Type: research
De novo hematopoietic (stem) cell generation - A differentiation or stochastic process?
This article touches upon these important issues, which may be relevant to the field's inability to make HSCs ex vivo.PMID:37806296 | DOI:10.1016/j.ceb.2023.102255 (Source: Current Opinion in Cell Biology)
Source: Current Opinion in Cell Biology - October 8, 2023 Category: Cytology Authors: Chris S Vink Anna Popravko Elaine Dzierzak Source Type: research
The impact of altered lamin B1 levels on nuclear lamina structure and function in aging and human diseases
Curr Opin Cell Biol. 2023 Oct 6;85:102257. doi: 10.1016/j.ceb.2023.102257. Online ahead of print.ABSTRACTThe role of lamin B1 in human health and aging has attracted increasing attention as mounting evidence reveals its significance in diverse cellular processes. Both upregulation and downregulation of lamin B1 have been implicated in age-associated organ dysfunctions and various human diseases, including central nervous system disorders. Additionally, lamin B1 levels undergo alterations in cancer cells, and a tumor-specific association exists between lamin B1 abundance and cancer aggressiveness. Investigating the connecti...
Source: Current Opinion in Cell Biology - October 8, 2023 Category: Cytology Authors: Youngjo Kim Source Type: research
Interplay of dynamic genome organization and biomolecular condensates
Curr Opin Cell Biol. 2023 Oct 6;85:102252. doi: 10.1016/j.ceb.2023.102252. Online ahead of print.ABSTRACTAfter 60 years of chromatin investigation, our understanding of chromatin organization has evolved from static chromatin fibers to dynamic nuclear compartmentalization. Chromatin is embedded in a heterogeneous nucleoplasm in which molecules are grouped into distinct compartments, partitioning nuclear space through phase separation. Human genome organization affects transcription which controls euchromatin formation by excluding inactive chromatin. Chromatin condensates have been described as either liquid-like or solid-...
Source: Current Opinion in Cell Biology - October 8, 2023 Category: Cytology Authors: Yu-Chieh Chung Li-Chun Tu Source Type: research
Functional domains of nuclear long noncoding RNAs: Insights into gene regulation and intracellular architecture
Curr Opin Cell Biol. 2023 Oct 6;85:102250. doi: 10.1016/j.ceb.2023.102250. Online ahead of print.ABSTRACTRecent functional research on long noncoding RNAs (lncRNAs) has revealed their significant regulatory roles in gene expression and intracellular architecture. Well-characterized examples of such lncRNAs include Xist and NEAT1_2, which play critical roles in heterochromatin formation of inactive X-chromosomes and paraspeckle assembly, in mammalian cells. Both lncRNAs possess modular domain structures with multiple functionally distinct domains that serve as platforms for specific RNA-binding proteins (RBPs), which dictat...
Source: Current Opinion in Cell Biology - October 8, 2023 Category: Cytology Authors: Chikashi Obuse Tetsuro Hirose Source Type: research
Regulation of immune cell development, differentiation and function by stromal Notch ligands
Curr Opin Cell Biol. 2023 Oct 6;85:102256. doi: 10.1016/j.ceb.2023.102256. Online ahead of print.ABSTRACTIn multicellular organisms, cell-to-cell communication is critical for the regulation of tissue organization. Notch signaling relies on direct interactions between Notch receptors on signal-receiving cells and Notch ligands on adjacent cells. Notch evolved to mediate local cellular interactions that are responsive to spatial cues via dosage-sensitive short-lived signals. Immune cells utilize these unique properties of Notch signaling to direct their development, differentiation, and function. In this review, we explore ...
Source: Current Opinion in Cell Biology - October 8, 2023 Category: Cytology Authors: Michael Schneider Anneka Allman Ivan Maillard Source Type: research
De novo hematopoietic (stem) cell generation - A differentiation or stochastic process?
This article touches upon these important issues, which may be relevant to the field's inability to make HSCs ex vivo.PMID:37806296 | DOI:10.1016/j.ceb.2023.102255 (Source: Current Opinion in Cell Biology)
Source: Current Opinion in Cell Biology - October 8, 2023 Category: Cytology Authors: Chris S Vink Anna Popravko Elaine Dzierzak Source Type: research
