Organelle adaptations in response to mechanical forces during tumour dissemination
Curr Opin Cell Biol. 2024 Mar 12;88:102345. doi: 10.1016/j.ceb.2024.102345. Online ahead of print.ABSTRACTCell migration plays a pivotal role in various biological processes including cancer dissemination and successful metastasis, where the role of mechanical signals is increasingly acknowledged. This review focuses on the intricate mechanisms through which cancer cells modulate their migratory strategies via organelle adaptations in response to the extracellular matrix (ECM). Specifically, the nucleus and mitochondria emerge as pivotal mediators in this process. These organelles serve as sensors, translating mechanical s...
Source: Current Opinion in Cell Biology - March 13, 2024 Category: Cytology Authors: Vittoria Graziani Eva Crosas-Molist Samantha L George Victoria Sanz-Moreno Source Type: research
Organelle adaptations in response to mechanical forces during tumour dissemination
Curr Opin Cell Biol. 2024 Mar 12;88:102345. doi: 10.1016/j.ceb.2024.102345. Online ahead of print.ABSTRACTCell migration plays a pivotal role in various biological processes including cancer dissemination and successful metastasis, where the role of mechanical signals is increasingly acknowledged. This review focuses on the intricate mechanisms through which cancer cells modulate their migratory strategies via organelle adaptations in response to the extracellular matrix (ECM). Specifically, the nucleus and mitochondria emerge as pivotal mediators in this process. These organelles serve as sensors, translating mechanical s...
Source: Current Opinion in Cell Biology - March 13, 2024 Category: Cytology Authors: Vittoria Graziani Eva Crosas-Molist Samantha L George Victoria Sanz-Moreno Source Type: research
Organelle adaptations in response to mechanical forces during tumour dissemination
Curr Opin Cell Biol. 2024 Mar 12;88:102345. doi: 10.1016/j.ceb.2024.102345. Online ahead of print.ABSTRACTCell migration plays a pivotal role in various biological processes including cancer dissemination and successful metastasis, where the role of mechanical signals is increasingly acknowledged. This review focuses on the intricate mechanisms through which cancer cells modulate their migratory strategies via organelle adaptations in response to the extracellular matrix (ECM). Specifically, the nucleus and mitochondria emerge as pivotal mediators in this process. These organelles serve as sensors, translating mechanical s...
Source: Current Opinion in Cell Biology - March 13, 2024 Category: Cytology Authors: Vittoria Graziani Eva Crosas-Molist Samantha L George Victoria Sanz-Moreno Source Type: research
Organelle adaptations in response to mechanical forces during tumour dissemination
Curr Opin Cell Biol. 2024 Mar 12;88:102345. doi: 10.1016/j.ceb.2024.102345. Online ahead of print.ABSTRACTCell migration plays a pivotal role in various biological processes including cancer dissemination and successful metastasis, where the role of mechanical signals is increasingly acknowledged. This review focuses on the intricate mechanisms through which cancer cells modulate their migratory strategies via organelle adaptations in response to the extracellular matrix (ECM). Specifically, the nucleus and mitochondria emerge as pivotal mediators in this process. These organelles serve as sensors, translating mechanical s...
Source: Current Opinion in Cell Biology - March 13, 2024 Category: Cytology Authors: Vittoria Graziani Eva Crosas-Molist Samantha L George Victoria Sanz-Moreno Source Type: research
Advantages of integrating Brillouin microscopy in multimodal mechanical mapping of cells and tissues
Curr Opin Cell Biol. 2024 Mar 11;88:102341. doi: 10.1016/j.ceb.2024.102341. Online ahead of print.ABSTRACTRecent research has highlighted the growing significance of the mechanical properties of cells and tissues in the proper execution of physiological functions within an organism; alterations to these properties can potentially result in various diseases. These mechanical properties can be assessed using various techniques that vary in spatial and temporal resolutions as well as applications. Due to the wide range of mechanical behaviors exhibited by cells and tissues, a singular mapping technique may be insufficient in ...
Source: Current Opinion in Cell Biology - March 12, 2024 Category: Cytology Authors: Chenchen Handler Claudia Testi Giuliano Scarcelli Source Type: research
Advantages of integrating Brillouin microscopy in multimodal mechanical mapping of cells and tissues
Curr Opin Cell Biol. 2024 Mar 11;88:102341. doi: 10.1016/j.ceb.2024.102341. Online ahead of print.ABSTRACTRecent research has highlighted the growing significance of the mechanical properties of cells and tissues in the proper execution of physiological functions within an organism; alterations to these properties can potentially result in various diseases. These mechanical properties can be assessed using various techniques that vary in spatial and temporal resolutions as well as applications. Due to the wide range of mechanical behaviors exhibited by cells and tissues, a singular mapping technique may be insufficient in ...
Source: Current Opinion in Cell Biology - March 12, 2024 Category: Cytology Authors: Chenchen Handler Claudia Testi Giuliano Scarcelli Source Type: research
Engines of change: Nonmuscle myosin II in mechanobiology
We describe how myosin II-generated forces drive two major types of events: modification of the cellular morphology and/or triggering of genetic programs, which enhance the ability of cells to adapt to, or modify, their microenvironment. Finally, we address whether targeting myosin II to impair or potentiate its activity at the motor level is a viable therapeutic strategy, as illustrated by recent examples aimed at modulating cardiac myosin II function in heart disease.PMID:38442667 | DOI:10.1016/j.ceb.2024.102344 (Source: Current Opinion in Cell Biology)
Source: Current Opinion in Cell Biology - March 5, 2024 Category: Cytology Authors: Marina Garrido-Casado Gloria Asensio-Ju árez Vanessa C Talayero Miguel Vicente-Manzanares Source Type: research
Engines of change: Nonmuscle myosin II in mechanobiology
We describe how myosin II-generated forces drive two major types of events: modification of the cellular morphology and/or triggering of genetic programs, which enhance the ability of cells to adapt to, or modify, their microenvironment. Finally, we address whether targeting myosin II to impair or potentiate its activity at the motor level is a viable therapeutic strategy, as illustrated by recent examples aimed at modulating cardiac myosin II function in heart disease.PMID:38442667 | DOI:10.1016/j.ceb.2024.102344 (Source: Current Opinion in Cell Biology)
Source: Current Opinion in Cell Biology - March 5, 2024 Category: Cytology Authors: Marina Garrido-Casado Gloria Asensio-Ju árez Vanessa C Talayero Miguel Vicente-Manzanares Source Type: research
Engines of change: Nonmuscle myosin II in mechanobiology
We describe how myosin II-generated forces drive two major types of events: modification of the cellular morphology and/or triggering of genetic programs, which enhance the ability of cells to adapt to, or modify, their microenvironment. Finally, we address whether targeting myosin II to impair or potentiate its activity at the motor level is a viable therapeutic strategy, as illustrated by recent examples aimed at modulating cardiac myosin II function in heart disease.PMID:38442667 | DOI:10.1016/j.ceb.2024.102344 (Source: Current Opinion in Cell Biology)
Source: Current Opinion in Cell Biology - March 5, 2024 Category: Cytology Authors: Marina Garrido-Casado Gloria Asensio-Ju árez Vanessa C Talayero Miguel Vicente-Manzanares Source Type: research
Engines of change: Nonmuscle myosin II in mechanobiology
We describe how myosin II-generated forces drive two major types of events: modification of the cellular morphology and/or triggering of genetic programs, which enhance the ability of cells to adapt to, or modify, their microenvironment. Finally, we address whether targeting myosin II to impair or potentiate its activity at the motor level is a viable therapeutic strategy, as illustrated by recent examples aimed at modulating cardiac myosin II function in heart disease.PMID:38442667 | DOI:10.1016/j.ceb.2024.102344 (Source: Current Opinion in Cell Biology)
Source: Current Opinion in Cell Biology - March 5, 2024 Category: Cytology Authors: Marina Garrido-Casado Gloria Asensio-Ju árez Vanessa C Talayero Miguel Vicente-Manzanares Source Type: research
Engines of change: Nonmuscle myosin II in mechanobiology
We describe how myosin II-generated forces drive two major types of events: modification of the cellular morphology and/or triggering of genetic programs, which enhance the ability of cells to adapt to, or modify, their microenvironment. Finally, we address whether targeting myosin II to impair or potentiate its activity at the motor level is a viable therapeutic strategy, as illustrated by recent examples aimed at modulating cardiac myosin II function in heart disease.PMID:38442667 | DOI:10.1016/j.ceb.2024.102344 (Source: Current Opinion in Cell Biology)
Source: Current Opinion in Cell Biology - March 5, 2024 Category: Cytology Authors: Marina Garrido-Casado Gloria Asensio-Ju árez Vanessa C Talayero Miguel Vicente-Manzanares Source Type: research
Engines of change: Nonmuscle myosin II in mechanobiology
We describe how myosin II-generated forces drive two major types of events: modification of the cellular morphology and/or triggering of genetic programs, which enhance the ability of cells to adapt to, or modify, their microenvironment. Finally, we address whether targeting myosin II to impair or potentiate its activity at the motor level is a viable therapeutic strategy, as illustrated by recent examples aimed at modulating cardiac myosin II function in heart disease.PMID:38442667 | DOI:10.1016/j.ceb.2024.102344 (Source: Current Opinion in Cell Biology)
Source: Current Opinion in Cell Biology - March 5, 2024 Category: Cytology Authors: Marina Garrido-Casado Gloria Asensio-Ju árez Vanessa C Talayero Miguel Vicente-Manzanares Source Type: research
Recent advances in label-free imaging and quantification techniques for the study of lipid droplets in cells
Curr Opin Cell Biol. 2024 Feb 29;87:102342. doi: 10.1016/j.ceb.2024.102342. Online ahead of print.ABSTRACTLipid droplets (LDs), once considered mere storage depots for lipids, have gained recognition for their intricate roles in cellular processes, including metabolism, membrane trafficking, and disease states like obesity and cancer. This review explores label-free imaging techniques' applications in LD research. We discuss holotomography and vibrational spectroscopic microscopy, emphasizing their potential for studying LDs without molecular labels, and we highlight the growing integration of artificial intelligence. Clin...
Source: Current Opinion in Cell Biology - March 1, 2024 Category: Cytology Authors: Hyeonwoo Kim Seungeun Oh Seongsoo Lee Kwang Suk Lee YongKeun Park Source Type: research
Recent advances in label-free imaging and quantification techniques for the study of lipid droplets in cells
Curr Opin Cell Biol. 2024 Feb 29;87:102342. doi: 10.1016/j.ceb.2024.102342. Online ahead of print.ABSTRACTLipid droplets (LDs), once considered mere storage depots for lipids, have gained recognition for their intricate roles in cellular processes, including metabolism, membrane trafficking, and disease states like obesity and cancer. This review explores label-free imaging techniques' applications in LD research. We discuss holotomography and vibrational spectroscopic microscopy, emphasizing their potential for studying LDs without molecular labels, and we highlight the growing integration of artificial intelligence. Clin...
Source: Current Opinion in Cell Biology - March 1, 2024 Category: Cytology Authors: Hyeonwoo Kim Seungeun Oh Seongsoo Lee Kwang Suk Lee YongKeun Park Source Type: research
Recent advances in label-free imaging and quantification techniques for the study of lipid droplets in cells
Curr Opin Cell Biol. 2024 Feb 29;87:102342. doi: 10.1016/j.ceb.2024.102342. Online ahead of print.ABSTRACTLipid droplets (LDs), once considered mere storage depots for lipids, have gained recognition for their intricate roles in cellular processes, including metabolism, membrane trafficking, and disease states like obesity and cancer. This review explores label-free imaging techniques' applications in LD research. We discuss holotomography and vibrational spectroscopic microscopy, emphasizing their potential for studying LDs without molecular labels, and we highlight the growing integration of artificial intelligence. Clin...
Source: Current Opinion in Cell Biology - March 1, 2024 Category: Cytology Authors: Hyeonwoo Kim Seungeun Oh Seongsoo Lee Kwang Suk Lee YongKeun Park Source Type: research
