Engines of change: Nonmuscle myosin II in mechanobiology

We describe how myosin II-generated forces drive two major types of events: modification of the cellular morphology and/or triggering of genetic programs, which enhance the ability of cells to adapt to, or modify, their microenvironment. Finally, we address whether targeting myosin II to impair or potentiate its activity at the motor level is a viable therapeutic strategy, as illustrated by recent examples aimed at modulating cardiac myosin II function in heart disease.PMID:38442667 | DOI:10.1016/j.ceb.2024.102344
Source: Current Opinion in Cell Biology - Category: Cytology Authors: Source Type: research