Astrocyte signaling and interactions in Multiple Sclerosis
Curr Opin Cell Biol. 2023 Dec 24;86:102307. doi: 10.1016/j.ceb.2023.102307. Online ahead of print.ABSTRACTMultiple Sclerosis (MS) is a common cause of impairment in working-aged adults. MS is characterized by neuroinflammation and infiltration of peripheral immune cells to the brain, which cause myelin loss and death of oligodendrocytes and neurons. Many studies on MS have focused on the peripheral immune sources of demyelination and repair. However, recent studies revealed that a glial cell type, the astrocytes, undergo robust morphological and transcriptomic changes that contribute significantly to demyelination and myel...
Source: Current Opinion in Cell Biology - December 25, 2023 Category: Cytology Authors: Crystal Col ón Ortiz Cagla Eroglu Source Type: research
Astrocyte signaling and interactions in Multiple Sclerosis
Curr Opin Cell Biol. 2023 Dec 24;86:102307. doi: 10.1016/j.ceb.2023.102307. Online ahead of print.ABSTRACTMultiple Sclerosis (MS) is a common cause of impairment in working-aged adults. MS is characterized by neuroinflammation and infiltration of peripheral immune cells to the brain, which cause myelin loss and death of oligodendrocytes and neurons. Many studies on MS have focused on the peripheral immune sources of demyelination and repair. However, recent studies revealed that a glial cell type, the astrocytes, undergo robust morphological and transcriptomic changes that contribute significantly to demyelination and myel...
Source: Current Opinion in Cell Biology - December 25, 2023 Category: Cytology Authors: Crystal Col ón Ortiz Cagla Eroglu Source Type: research
Nuclear roles for non-lamin intermediate filament proteins
Curr Opin Cell Biol. 2023 Dec 18;86:102303. doi: 10.1016/j.ceb.2023.102303. Online ahead of print.ABSTRACTThe nuclear-localized lamins have long been thought to be the only intermediate filaments (IFs) with an impact on the architecture, properties, and functions of the nucleus. Recent studies, however, uncovered significant roles for IFs other than lamins (here referred to as "non-lamin IFs") in regulating key properties of the nucleus in various cell types and biological settings. In the cytoplasm, IFs often occur in the perinuclear space where they contribute to local stiffness and impact the shape and/or the integrity ...
Source: Current Opinion in Cell Biology - December 19, 2023 Category: Cytology Authors: Pierre A Coulombe Christopher M Pineda Justin T Jacob Raji R Nair Source Type: research
Regulation of protein synthesis and stability by mechanical cues and its implications in cancer
Curr Opin Cell Biol. 2023 Dec 18;86:102304. doi: 10.1016/j.ceb.2023.102304. Online ahead of print.ABSTRACTElevated tissue stiffness is a common feature of many solid tumors and the downstream mechanical signaling affects many cellular processes and contributes to cancer progression. Significant progress has been made in understanding how the mechanical properties of the matrix affect cancer cell behavior as well as transcription. However, how the same mechanical cues impact protein synthesis and stability and how this may contribute to disease is less well understood. Here, we present emerging evidence that cancer progress...
Source: Current Opinion in Cell Biology - December 19, 2023 Category: Cytology Authors: Sara G öransson Staffan Str ömblad Source Type: research
Nuclear roles for non-lamin intermediate filament proteins
Curr Opin Cell Biol. 2023 Dec 18;86:102303. doi: 10.1016/j.ceb.2023.102303. Online ahead of print.ABSTRACTThe nuclear-localized lamins have long been thought to be the only intermediate filaments (IFs) with an impact on the architecture, properties, and functions of the nucleus. Recent studies, however, uncovered significant roles for IFs other than lamins (here referred to as "non-lamin IFs") in regulating key properties of the nucleus in various cell types and biological settings. In the cytoplasm, IFs often occur in the perinuclear space where they contribute to local stiffness and impact the shape and/or the integrity ...
Source: Current Opinion in Cell Biology - December 19, 2023 Category: Cytology Authors: Pierre A Coulombe Christopher M Pineda Justin T Jacob Raji R Nair Source Type: research
Regulation of protein synthesis and stability by mechanical cues and its implications in cancer
Curr Opin Cell Biol. 2023 Dec 18;86:102304. doi: 10.1016/j.ceb.2023.102304. Online ahead of print.ABSTRACTElevated tissue stiffness is a common feature of many solid tumors and the downstream mechanical signaling affects many cellular processes and contributes to cancer progression. Significant progress has been made in understanding how the mechanical properties of the matrix affect cancer cell behavior as well as transcription. However, how the same mechanical cues impact protein synthesis and stability and how this may contribute to disease is less well understood. Here, we present emerging evidence that cancer progress...
Source: Current Opinion in Cell Biology - December 19, 2023 Category: Cytology Authors: Sara G öransson Staffan Str ömblad Source Type: research
Nuclear roles for non-lamin intermediate filament proteins
Curr Opin Cell Biol. 2023 Dec 18;86:102303. doi: 10.1016/j.ceb.2023.102303. Online ahead of print.ABSTRACTThe nuclear-localized lamins have long been thought to be the only intermediate filaments (IFs) with an impact on the architecture, properties, and functions of the nucleus. Recent studies, however, uncovered significant roles for IFs other than lamins (here referred to as "non-lamin IFs") in regulating key properties of the nucleus in various cell types and biological settings. In the cytoplasm, IFs often occur in the perinuclear space where they contribute to local stiffness and impact the shape and/or the integrity ...
Source: Current Opinion in Cell Biology - December 19, 2023 Category: Cytology Authors: Pierre A Coulombe Christopher M Pineda Justin T Jacob Raji R Nair Source Type: research
Regulation of protein synthesis and stability by mechanical cues and its implications in cancer
Curr Opin Cell Biol. 2023 Dec 18;86:102304. doi: 10.1016/j.ceb.2023.102304. Online ahead of print.ABSTRACTElevated tissue stiffness is a common feature of many solid tumors and the downstream mechanical signaling affects many cellular processes and contributes to cancer progression. Significant progress has been made in understanding how the mechanical properties of the matrix affect cancer cell behavior as well as transcription. However, how the same mechanical cues impact protein synthesis and stability and how this may contribute to disease is less well understood. Here, we present emerging evidence that cancer progress...
Source: Current Opinion in Cell Biology - December 19, 2023 Category: Cytology Authors: Sara G öransson Staffan Str ömblad Source Type: research
Nuclear roles for non-lamin intermediate filament proteins
Curr Opin Cell Biol. 2023 Dec 18;86:102303. doi: 10.1016/j.ceb.2023.102303. Online ahead of print.ABSTRACTThe nuclear-localized lamins have long been thought to be the only intermediate filaments (IFs) with an impact on the architecture, properties, and functions of the nucleus. Recent studies, however, uncovered significant roles for IFs other than lamins (here referred to as "non-lamin IFs") in regulating key properties of the nucleus in various cell types and biological settings. In the cytoplasm, IFs often occur in the perinuclear space where they contribute to local stiffness and impact the shape and/or the integrity ...
Source: Current Opinion in Cell Biology - December 19, 2023 Category: Cytology Authors: Pierre A Coulombe Christopher M Pineda Justin T Jacob Raji R Nair Source Type: research
Regulation of protein synthesis and stability by mechanical cues and its implications in cancer
Curr Opin Cell Biol. 2023 Dec 18;86:102304. doi: 10.1016/j.ceb.2023.102304. Online ahead of print.ABSTRACTElevated tissue stiffness is a common feature of many solid tumors and the downstream mechanical signaling affects many cellular processes and contributes to cancer progression. Significant progress has been made in understanding how the mechanical properties of the matrix affect cancer cell behavior as well as transcription. However, how the same mechanical cues impact protein synthesis and stability and how this may contribute to disease is less well understood. Here, we present emerging evidence that cancer progress...
Source: Current Opinion in Cell Biology - December 19, 2023 Category: Cytology Authors: Sara G öransson Staffan Str ömblad Source Type: research
Nuclear roles for non-lamin intermediate filament proteins
Curr Opin Cell Biol. 2023 Dec 18;86:102303. doi: 10.1016/j.ceb.2023.102303. Online ahead of print.ABSTRACTThe nuclear-localized lamins have long been thought to be the only intermediate filaments (IFs) with an impact on the architecture, properties, and functions of the nucleus. Recent studies, however, uncovered significant roles for IFs other than lamins (here referred to as "non-lamin IFs") in regulating key properties of the nucleus in various cell types and biological settings. In the cytoplasm, IFs often occur in the perinuclear space where they contribute to local stiffness and impact the shape and/or the integrity ...
Source: Current Opinion in Cell Biology - December 19, 2023 Category: Cytology Authors: Pierre A Coulombe Christopher M Pineda Justin T Jacob Raji R Nair Source Type: research
Regulation of protein synthesis and stability by mechanical cues and its implications in cancer
Curr Opin Cell Biol. 2023 Dec 18;86:102304. doi: 10.1016/j.ceb.2023.102304. Online ahead of print.ABSTRACTElevated tissue stiffness is a common feature of many solid tumors and the downstream mechanical signaling affects many cellular processes and contributes to cancer progression. Significant progress has been made in understanding how the mechanical properties of the matrix affect cancer cell behavior as well as transcription. However, how the same mechanical cues impact protein synthesis and stability and how this may contribute to disease is less well understood. Here, we present emerging evidence that cancer progress...
Source: Current Opinion in Cell Biology - December 19, 2023 Category: Cytology Authors: Sara G öransson Staffan Str ömblad Source Type: research
Nuclear roles for non-lamin intermediate filament proteins
Curr Opin Cell Biol. 2023 Dec 18;86:102303. doi: 10.1016/j.ceb.2023.102303. Online ahead of print.ABSTRACTThe nuclear-localized lamins have long been thought to be the only intermediate filaments (IFs) with an impact on the architecture, properties, and functions of the nucleus. Recent studies, however, uncovered significant roles for IFs other than lamins (here referred to as "non-lamin IFs") in regulating key properties of the nucleus in various cell types and biological settings. In the cytoplasm, IFs often occur in the perinuclear space where they contribute to local stiffness and impact the shape and/or the integrity ...
Source: Current Opinion in Cell Biology - December 19, 2023 Category: Cytology Authors: Pierre A Coulombe Christopher M Pineda Justin T Jacob Raji R Nair Source Type: research
Regulation of protein synthesis and stability by mechanical cues and its implications in cancer
Curr Opin Cell Biol. 2023 Dec 18;86:102304. doi: 10.1016/j.ceb.2023.102304. Online ahead of print.ABSTRACTElevated tissue stiffness is a common feature of many solid tumors and the downstream mechanical signaling affects many cellular processes and contributes to cancer progression. Significant progress has been made in understanding how the mechanical properties of the matrix affect cancer cell behavior as well as transcription. However, how the same mechanical cues impact protein synthesis and stability and how this may contribute to disease is less well understood. Here, we present emerging evidence that cancer progress...
Source: Current Opinion in Cell Biology - December 19, 2023 Category: Cytology Authors: Sara G öransson Staffan Str ömblad Source Type: research
Mechanotransduction through membrane tension: It's all about propagation?
Curr Opin Cell Biol. 2023 Dec 14;86:102294. doi: 10.1016/j.ceb.2023.102294. Online ahead of print.ABSTRACTOver the past 25 years, membrane tension has emerged as a primary mechanical factor influencing cell behavior. Although supporting evidences are accumulating, the integration of this parameter in the lifecycle of cells, organs, and tissues is complex. The plasma membrane is envisioned as a bilayer continuum acting as a 2D fluid. However, it possesses almost infinite combinations of proteins, lipids, and glycans that establish interactions with the extracellular or intracellular environments. This results in a tridimens...
Source: Current Opinion in Cell Biology - December 15, 2023 Category: Cytology Authors: Andrea Ghisleni Nils C Gauthier Source Type: research
